Nasion Swelling as the Presenting Symptom of Lung Adenocarcinoma

AbstractMetastasis to the paranasal sinuses from lung cancer is extremely rare. Here, we reported a patient of lung adenocarcinoma presenting with nasion swelling because of metastasis to the paranasal sinuses. A review of the literature from 1966 to 2008 yielded another 15 patients. Adenocarcinoma was the most commonly encountered histologic subtype, and modern combination chemotherapy was probably the most effective treatment modality. Headache, visual disturbance, facial mass, and facial pain were the symptoms frequently associated with paranasal sinus metastasis; however, all of them were nonspecific for a metastatic tumor. A thorough history taking, ear, nose, and throat examination, and laboratory investigations are of paramount importance to achieve a correct diagnosis

A study of deep levels of AlGaAs/GaAs heterojunction bipolar transistors

A study of deep levels of the emitter region of a heterojunction bipolar transistor is investigated using deep level transient spectroscopy (DLTS), deep level admittance spectroscopy (DLAS), thermally stimulated capacitance (TSCAP), and capacitance-voltage (C-V) profiling. The DX center, with an activation energy of 0.45 eV, is the only deep level detected. By varying the DLTS rate window and filling pulse widths, DX is found to be comprise of two closely spaced DX centers, denoted DX1 and DX2. A positive peak observed in the DLTS spectra is attributed to electron capture, not minority carrier emission, and, thus, is an experimental artifact. Finally, the reduction of current gain (β) at low collector current and the effect of the DX center on the switching characteristics of HBTs are briefly discussed

Targeting delivery of paclitaxel into tumor cells via somatostatin receptor endocytosis

AbstractBackground: The binding of somatostatin (SST) to endogenous G-protein-coupled receptors (SST receptors or SSTRs) is followed by internalization of SST, and, several reports have shown that a high density of SSTRs is present on most hormone-secreting tissue tumors. Facile synthesis of the long-acting SST analog, octreotide, has previously been described. Octreotide might be of practical value in developing tumor tracers and in serving as a carrier of cytotoxic antitumor drugs.Results: Fluorescein-labeled octreotide was internalized into the cytosol of human breast MCF-7 carcinoma cells via binding to SSTRs. Octreotide-conjugated paclitaxel (taxol) was created by coupling taxol–succinate to the amino-terminal end of octreotide. This conjugate retains the biological activity of taxol in inducing formation of tubulin bundles, eventually causing apoptosis of MCF-7 cells. Cytotoxicity of octreotide-conjugated taxol is mainly mediated by SSTR, as shown by the observation that octreotide pretreatment can rescue the induced cell death. In comparison with free taxol, this conjugate shows much less toxicity in Chinese hamster ovary cells.Conclusions: Octreotide-conjugated taxol exerts the same antitumor effect of free taxol on stabilizing microtubule formation and inducing cell death. This conjugate triggers tumor cell apoptosis mediated by SSTRs and is exclusively toxic to SSTR-expressing cells. Octreotide-conjugated taxol is less toxic to low-SSTR-expressing cells compared with free taxol. Our results strongly indicated that octreotide-conjugated taxol demonstrates cell selectivity and may be used as a targeting agent for cancer therapy

Regulation of axon repulsion by MAX-1 SUMOylation and AP-3.

During neural development, growing axons express specific surface receptors in response to various environmental guidance cues. These axon guidance receptors are regulated through intracellular trafficking and degradation to enable navigating axons to reach their targets. In Caenorhabditis elegans, the UNC-5 receptor is necessary for dorsal migration of developing motor axons. We previously found that MAX-1 is required for UNC-5-mediated axon repulsion, but its mechanism of action remained unclear. Here, we demonstrate that UNC-5-mediated axon repulsion in C. elegans motor axons requires both max-1 SUMOylation and the AP-3 complex β subunit gene, apb-3 Genetic interaction studies show that max-1 is SUMOylated by gei-17/PIAS1 and acts upstream of apb-3 Biochemical analysis suggests that constitutive interaction of MAX-1 and UNC-5 receptor is weakened by MAX-1 SUMOylation and by the presence of APB-3, a competitive interactor with UNC-5. Overexpression of APB-3 reroutes the trafficking of UNC-5 receptor into the lysosome for protein degradation. In vivo fluorescence recovery after photobleaching experiments shows that MAX-1 SUMOylation and APB-3 are required for proper trafficking of UNC-5 receptor in the axon. Our results demonstrate that SUMOylation of MAX-1 plays an important role in regulating AP-3-mediated trafficking and degradation of UNC-5 receptors during axon guidance

THE ACUTE EFFECT OF UPPER EXTREMITY PLYOMETRIC TRAINING

The purpose of this study was to probe the acute effect of the performance of upper extremity muscle groups after the plyometric training intervention. The participants were 13 healthy male college students. The force transducers (300kg, 200 Hz) and EMG sensor (1000 Hz) were taken to diagnose the acute effects of strength and muscle activation done by upper extremity pre and post plyometric training (load :24kg, 12 repetiiion times Iset, 3 set), and pair t-test was taken to test the significance(a=.05). The result showed that the strength after the upper extremity plyometric training intervention obviously had decreased 8% (

ELEMENTARY SCHOOL BOYS’ SOCCER KICK SKILL ANALYSIS

The purpose of this study is aimed to analyze elementary school boys’ kicking skills on the perspective of motor skills. The data is collected by Vicon Motion Analysis System (250Hz). The parameters include the compare of the instant joint angles and the time proportion during the process of the kicking toward the different kick performance groups. The participants are 36 elementary boy soccer players (age: 11.7±0.3 yrs; height: 1.42±0.13 m; weight: 37.5±13.0 kg). The subjects were divided to two groups according to the instance kicking ball speed. The result indicated that the high ball speed group players have greater extremity joint angles than the low ball speed group. No difference was found on the time proportion during the process of the kicking. We suggest that the learning of kicking skill can start with the lower speed in the beginner stage

Fast-Flux Bot Detection in Real Time

Abstract. The fast-flux service network architecture has been widely adopted by bot herders to increase the productivity and extend the lifes-pan of botnets ’ domain names. A fast-flux botnet is unique in that each of its domain names is normally mapped to different sets of IP addresses over time and legitimate users ’ requests are handled by machines other than those contacted by users directly. Most existing methods for de-tecting fast-flux botnets rely on the former property. This approach is effective, but it requires a certain period of time, maybe a few days, before a conclusion can be drawn. In this paper, we propose a novel way to detect whether a web service is hosted by a fast-flux botnet in real time. The scheme is unique because it relies on certain intrinsic and invariant characteristics of fast-flux bot-nets, namely, 1) the request delegation model, 2) bots are not dedicated to malicious services, and 3) the hardware used by bots is normally infe-rior to that of dedicated servers. Our empirical evaluation results show that, using a passive measurement approach, the proposed scheme can detect fast-flux bots in a few seconds with more than 96 % accuracy, while the false positive/negative rates are both lower than 5%