Smoothing Accelerated Proximal Gradient Method with Fast Convergence Rate for Nonsmooth Multi-objective Optimization

This paper introduces a novel approach to nonsmooth multiobjective optimization through the proposal of a Smoothing Accelerated Proximal Gradient Method with Extrapolation Term (SAPGM). Leveraging the foundation of smoothing methods and the accelerated algorithm for multiobjective optimization by Tanabe et al., our method exhibits a refined convergence rate. Specifically, we establish that the convergence rate of our proposed method can be enhanced from $O(1/k^2)$ to $o(1/k^2)$ by incorporating a distinct extrapolation term $\frac{k-1}{k + \alpha -1}$ with $\alpha > 3$.Moreover, we prove that the iterates sequence is convergent to an optimal solution of the problem. Furthermore, we present an effective strategy for solving the subproblem through its dual representation, validating the efficacy of the proposed method through a series of numerical experiments.Comment: arXiv admin note: substantial text overlap with arXiv:2202.10994 by other authors; text overlap with arXiv:2110.01454 by other authors without attributio

Single-User Injection for Invisible Shilling Attack against Recommender Systems

Recommendation systems (RS) are crucial for alleviating the information overload problem. Due to its pivotal role in guiding users to make decisions, unscrupulous parties are lured to launch attacks against RS to affect the decisions of normal users and gain illegal profits. Among various types of attacks, shilling attack is one of the most subsistent and profitable attacks. In shilling attack, an adversarial party injects a number of well-designed fake user profiles into the system to mislead RS so that the attack goal can be achieved. Although existing shilling attack methods have achieved promising results, they all adopt the attack paradigm of multi-user injection, where some fake user profiles are required. This paper provides the first study of shilling attack in an extremely limited scenario: only one fake user profile is injected into the victim RS to launch shilling attacks (i.e., single-user injection). We propose a novel single-user injection method SUI-Attack for invisible shilling attack. SUI-Attack is a graph based attack method that models shilling attack as a node generation task over the user-item bipartite graph of the victim RS, and it constructs the fake user profile by generating user features and edges that link the fake user to items. Extensive experiments demonstrate that SUI-Attack can achieve promising attack results in single-user injection. In addition to its attack power, SUI-Attack increases the stealthiness of shilling attack and reduces the risk of being detected. We provide our implementation at: https://github.com/KDEGroup/SUI-Attack.Comment: CIKM 2023. 10 pages, 5 figure

Screening of Potential Hub Genes in Glioma Progression Based on Bioinformatics Analysis

Objectives: Glioma is the most common primary tumor of the central nervous system, and its therapeutic effect is not optimistic. In recent years, related therapeutic technologies have developed rapidly, but unfortunately, the improvement of clinical therapeutic effect is not satisfactory. In addition to conventional therapies, there are some attractive therapies, such as biological therapy (immunotherapy), gene therapy, etc[1]. Therefore, searching for potential target genes of glioma is of great significance for developing new therapeutic directions and designing new biomarkers[2]. Methods: Download gene expression data set, GSE137902 gelatin and GSE13790 matrix through NCBI-G to screen overlapping differential expression genes (DEGs). In order to identify central genes from these genes, we conducted protein protein interaction (PPI) network. To further explore the potential mechanism of central genes in glioma, we performed gene ontology (GO) and Kyoto Gene and Genome Encyclopedia (KEGG) analysis. Then get the intersection of key genes according to five algorithms of Closeness Degree EPC MCC Stress. The intersection is obtained through GSE117423, GSE188256 and GSE90598 in geo database, and finally verified through Receiver Operating Characteristic (ROC) curve. Results: A total of 1274 differentially expressed genes are identified, and then 309 genes are obtained by intersection of the two. 16 Hub genes were obtained, and then the intersection of the two genes with GSE117423, GES188256 and GSE90598 genes was verified to obtain the key gene TIMP1 of glioma. Made the ROC curve of key gene.The intersection with hub gene was determined to identify TIMP1 as the key gene. Conclusion: The DEGs and Hub genes and signal pathways found in this study can confirm that the key gene TIMP1 is closely related to the occurrence and evolution of glioma, and provide candidate targets for the diagnosis and treatment of glioma

Development of Food-Luring Baited Traps for Solenopsis invicta (Hymenoptera: Formicidae) Monitoring in the Field in Southern China

Solenopsis invicta Buren (Hymenoptera: Formicidae), a red imported fire ant that originated from South America, is a worldwide invasive pest. This study investigated the efficacy of the newly designed baited trap to detect red imported fire ants, Solenopsis invicta Buren, under field conditions in China. Among the five food lures tested for red imported fire ants, the ants preferred ham sausage and fish powder, followed by mixed powder (50% fish powder + 50% black soldier fly powder) and black soldier fly powder. These lures were compared to sugar water (control) to determine their efficacy in trapping red imported fire ants. Field data revealed that the ham sausage powder trap was more efficient than the fish powder trap based on its ability to trap more red imported fire ants under field conditions and ease of use. Thus, it was concluded that the baited traps are efficient for longterm red imported fire ants monitoring

Characteristics of DNA-AuNP networks on cell membranes and real-time movies for viral infection

AbstractThis data article provides complementary data for the article entitled “DNA-AuNP networks on cell membranes as a protective barrier to inhibit viral attachment, entry and budding” Li et al. (2016) [1]. The experimental methods for the preparation and characterization of DNA-conjugated nanoparticle networks on cell membranes were described. Confocal fluorescence images, agarose gel electrophoresis images and hydrodynamic diameter of DNA-conjugated gold nanoparticle (DNA-AuNP) networks were presented. In addition, we have prepared QDs-labeled RSV (QDs-RSV) to real-time monitor the RSV infection on HEp-2 cells in the absence and presence of DNA-AuNP networks. Finally, the cell viability of HEp-2 cells coated by six types of DNA-nanoparticle networks was determined after RSV infection

The role of upfront primary tumor resection in asymptomatic patients with unresectable stage IV colorectal cancer: A systematic review and meta-analysis

BackgroundControversy exists over the role of upfront primary tumor resection (PTR) in asymptomatic patients with unresectable stage IV colorectal cancer (CRC). The purpose of this study was to evaluate the effect of upfront PTR on survival outcomes and adverse outcomes.MethodsSearches were conducted on PubMed, EMBASE, Web of Science, and Cochrane Library from inception to August 2021. Studies comparing survival outcomes with or without adverse outcomes between PTR and non-PTR treatments were included. Review Manager 5.3 was applied for meta-analyses with a random-effects model whenever possible.ResultsOverall, 20 studies with 3,088 patients were finally included in this systematic review. Compared with non-PTR, upfront PTR was associated with better 3-year (HR: 0.69, 95% CI, 0.57–0.83, P = 0.0001) and 5-year overall survival (OS) (HR: 0.77, 95% CI, 0.62–0.95, P = 0.01), while subgroup analysis indicated that there was no significant difference between upfront PTR and upfront chemotherapy (CT) group. In addition, grade 3 or higher adverse effects due to CT were more frequent in the PTR group with marginal significance (OR: 1.74, 95% CI, 0.99–3.06, P = 0.05), and other adverse outcomes were comparable.ConclusionsPTR might be related to improved OS for asymptomatic patients with unresectable stage IV CRC, whereas receiving upfront CT is a rational alternative without detrimental influence on survival or adverse outcomes compared with upfront PTR.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?RecordID=27267

Psychological symptoms in Chinese nurses may be associated with predisposition to chronic disease: A cross-sectional study of suboptimal health status

© 2020, The Author(s). Background: Suboptimal health status (SHS) is a reversible state between ideal health and illness and it can be effectively reversed by risk prediction, disease prevention, and personalized medicine under the global background of predictive, preventive, and personalized medicine (PPPM) concepts. More and more Chinese nurses have been troubled by psychological symptoms (PS). The correlation between PS and SHS is unclear in nurses. The purpose of current study is to investigate the prevalence of SHS and PS in Chinese nurses and the relationship between SHS and PS along with predisposing factors as well as to discuss the feasibility of improving health status and preventing diseases according to PPPM concepts in Chinese nurses. Methods: A cross-sectional study was conducted with the cluster sampling method among 9793 registered nurses in Foshan city, China. SHS was evaluated with the Suboptimal Health Status Questionnaire-25 (SHSQ-25). Meanwhile, the PS of depression and anxiety were evaluated with Self-Rating Depression Scale (SDS) and Self-Rating Anxiety Scale (SAS) self-assessment questionnaires. The relationship between PS and SHS in Chinese nurses was subsequently analyzed. Results: Among the 9793 participants, 6107 nurses were included in the final analysis. The prevalence of SHS in the participants was 74.21% (4532/6107) while the symptoms of depression and anxiety were 47.62% (2908/6107) and 24.59% (1502/6107) respectively. The prevalence of SHS in the participants with depression and anxiety was significantly higher than those without the symptoms of depression (83.3% vs 16.7%, P \u3c 0.001) and anxiety (94.2% vs 5.8%, P \u3c 0.0001). The ratio of exercise habit was significantly lower than that of non-exercise habit (68.8% vs 78.4%, P \u3c 0.001) in SHS group. Conclusions: There is a high prevalence of SHS and PS in Chinese nurses. PS in Chinese nurses are associated with SHS. Physical exercise is a protective factor for SHS and PS so that the exercise should be strongly recommended as a valuable preventive measure well in the agreement with PPPM philosophy. Along with SDS and SAS, SHSQ-25 should also be highly recommended and applied as a novel predictive/preventive tool for the health measures from the perspectives of PPPM in view of susceptible population and individual screening, the predisposition to chronic disease preventing, personalization of intervention, and the ideal health state restoring

Gonadal hormones and metabolic syndrome in middle-aged and elderly males: results from a prospective cohort study in China

BackgroundResearch has shown that gonadal hormones are involved in metabolic pathways relevant to metabolic syndrome (MetS). Nevertheless, no longitudinal study has been conducted on the association between SHBG and MetS in Chinese. The objective of our study was to determine whether there is any association between middle-aged and elderly males in China.MethodsA total of 531 eligible male subjects, aged above 40 years or older, without MetS at baseline, were recruited. Sex hormone binding globulin (SHBG), total testosterone (TT), follicle-stimulating hormone (FSH), and luteinizing hormone (LH) were measured. A harmonized definition and recommended thresholds for the Chinese population were used to determine metabolic syndrome.ResultsDuring 3.2 years of follow-up, 20.7% of subjects had developed MetS. Compared with the non-MetS group, subjects in the new-onset MetS group had significantly lower SHBG (43.5 nmol/L [28.8, 74.9] vs 53.7nmol/L [33.8, 115.0], P=0.0018), TT (18.1nmol/L [13.6–21.7] vs 19.5nmol/L[15.0–23.6], P=0.0204), and LH (5.13mIU/L [3.63–7.29] vs 5.87mIU/L [4.05–8.36]) at baseline. The incidence of MetS was decreased according to elevated SHBG quartiles (Q1:26.9%, Q2:22.7%, Q3:21.1%, Q4:12.1%, P for trend =0.0035), TT (Q1: 25.2%, Q2:23.7%, Q3: 17.3%, Q4: 16.7%, P for trend=0.0425), and LH (Q1:25.0%, Q2:21.8%, Q3: 21.8%, Q4: 14.3%, P for trend=0.0411). Compared with those in quartile 4, the OR[CI] of incident MetS for participants in Quartile 1 was 2.33[1.13–4.79] after multiple adjustments. But associations between incident MetS and different quartiles of LH, TT, and FSH were not observed after multiple adjustments. In the subgroup analyses, the significant association between SHBG level and Mets was detected in subjects over 60 years or older, with normal BMI, without insulin resistance, and with eGFR ≥90 mL/min per 1.73m2.ConclusionCompared with TT, LH, and FSH, a lower level of SHBG is significantly related to the incidence of MetS among middle-aged and elderly males in China

Whole-genome sequencing of <em>Oryza brachyantha</em> reveals mechanisms underlying <em>Oryza</em> genome evolution

The wild species of the genus Oryza contain a largely untapped reservoir of agronomically important genes for rice improvement. Here we report the 261-Mb de novo assembled genome sequence of Oryza brachyantha. Low activity of long-terminal repeat retrotransposons and massive internal deletions of ancient long-terminal repeat elements lead to the compact genome of Oryza brachyantha. We model 32,038 protein-coding genes in the Oryza brachyantha genome, of which only 70% are located in collinear positions in comparison with the rice genome. Analysing breakpoints of non-collinear genes suggests that double-strand break repair through non-homologous end joining has an important role in gene movement and erosion of collinearity in the Oryza genomes. Transition of euchromatin to heterochromatin in the rice genome is accompanied by segmental and tandem duplications, further expanded by transposable element insertions. The high-quality reference genome sequence of Oryza brachyantha provides an important resource for functional and evolutionary studies in the genus Oryza

イブンカ コミュニケーション ニオケル ダイガクセイ ノ ジコ カイジ ニカンスル ヒカク ケンキュウ : ニッチュウカン ダイガクセイ ノ ヒカク オ チュウシン ニ

日中韓3ヵ国の大学生の自文化における自己開示の傾向には開示行動、開示意向、開示方法について多くの共通点がみられるが、開示動機については相違点がみられる。その傾向の日中韓比較においては各々の特徴も見出される。これらの相違や特徴を背景とした異文化コミュニケーションにおける自己開示に際して、戸惑い、誤解、文化差などが経験される。各々の自己開示は、言語的制約を内包しつつ、文化的社会的制約を常に負う。また、文化的な相互依存と文化的な相互対峙が地球規模で急速に進んでいるグローバリゼーションの状況に人間は直面している。それゆえに、文化的社会的制約を負いつつも他者を他者性として自覚し、対話的な自己開示を遂行していく人間としての在り方が絶えず問題になる。自己開示を通して人間の人間性を問題にし続けること、多文化社会に生きる人間としての在り方を絶えず志向することが大学教育において要請される