8,296 research outputs found
Does external trade promote financial development?
Several recent papers have argued that trade and financial development may be linked, either for political economy reasons, or because foreign competition and exposure to shocks lead to changes in the demand for external finance. In this paper we use the cross-country and time-series variation in openness to study the relationship between trade and finance in more detail. Our results suggest that increases in goods market openness are typically followed by sustained increases in financial depth.openness, trade, financial development.
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Defined factors to reactivate cell cycle activity in adult mouse cardiomyocytes.
Adult mammalian cardiomyocytes exit the cell cycle during the neonatal period, commensurate with the loss of regenerative capacity in adult mammalian hearts. We established conditions for long-term culture of adult mouse cardiomyocytes that are genetically labeled with fluorescence. This technique permits reliable analyses of proliferation of pre-existing cardiomyocytes without complications from cardiomyocyte marker expression loss due to dedifferentiation or significant contribution from cardiac progenitor cell expansion and differentiation in culture. Using this system, we took a candidate gene approach to screen for fetal-specific proliferative gene programs that can induce proliferation of adult mouse cardiomyocytes. Using pooled gene delivery and subtractive gene elimination, we identified a novel functional interaction between E2f Transcription Factor 2 (E2f2) and Brain Expressed X-Linked (Bex)/Transcription elongation factor A-like (Tceal) superfamily members Bex1 and Tceal8. Specifically, Bex1 and Tceal8 both preserved cell viability during E2f2-induced cell cycle re-entry. Although Tceal8 inhibited E2f2-induced S-phase re-entry, Bex1 facilitated DNA synthesis while inhibiting cell death. In sum, our study provides a valuable method for adult cardiomyocyte proliferation research and suggests that Bex family proteins may function in modulating cell proliferation and death decisions during cardiomyocyte development and maturation
What's Cookin'? Interpreting Cooking Videos using Text, Speech and Vision
We present a novel method for aligning a sequence of instructions to a video
of someone carrying out a task. In particular, we focus on the cooking domain,
where the instructions correspond to the recipe. Our technique relies on an HMM
to align the recipe steps to the (automatically generated) speech transcript.
We then refine this alignment using a state-of-the-art visual food detector,
based on a deep convolutional neural network. We show that our technique
outperforms simpler techniques based on keyword spotting. It also enables
interesting applications, such as automatically illustrating recipes with
keyframes, and searching within a video for events of interest.Comment: To appear in NAACL 201
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