41 research outputs found

    Understanding the effects of doctors’ online profile pictures on patients’ decision-making

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    The effect of doctors’ profile pictures in online healthcare platforms has been investigated in prior research. However, little attention has focused on professional signals conveyed by doctors’ online profile pictures. To address the above-mentioned gap, this study examines the roles of doctors’ profile pictures in patients’ online decision-making based on cue utilization theory and impression management theory. Our research finds that a picture indicating professional information (e.g., professional attire and professional background) matters in attracting patients’ interest and their decision-making. However, the impacts of professional information change according to patients’ illness severity. Specifically, patients with low-severity illnesses care more about professional attire in the stage of glancing physicians, while patients with high-severity illnesses care more about professional attire in the stage of decision making. These findings contribute to the domain knowledge of online service design and delivery, especially in the arena of online health services

    Relationship between the current status of research on geological storage of solid, liquid and gas wastes in coal mines and the coordinated development of the ecological environment in China

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    China is a country in the world with the serious environmental pollution of coal mine “three wastes” (solid, liquid, gas). A lot of in-depth research and practice has been carried out on the utilization and treatment of “three wastes”. However, there are still many problems such as imperfect standards and norms, small scale of treatment and unsound technology. In order to solve the problem of synergistic development of low-cost geological storage of large-scale “three wastes” and ecological environment in China’s coal mines, on the basis of the definition of geological storage in other countries, the connotation of geological storage in China has been expanded. The progress and current status of research on the geological storage of “three wastes” are analyzed. Literature and patents related to the geological storage of “three wastes” at home and abroad are reviewed. The problems faced by China in carrying out the geological storage of “three wastes” and the suggestions for further development are put forward. It is pointed out that the main problem faced by the geological storage of “three wastes” in China is the inadequacy of the standards and regulations in the field of environment, especially the extensive lack of standards for the deep-well injection of waste liquids. The systematic research has shown that the research institutions in China are paying increasing attention to research in the field of the geological storage of the “three wastes”, and that the results of the research account for a high percentage of research in the world. China’s coal mine “three wastes” geological storage and ecological environment synergistic development awareness and system is being formed. However, there is insufficient support for research on the large-scale geological storage of “three wastes”, the cyclic system of geological storage of “three wastes” in the whole cycle of coal mining, and the synergistic relationship between CO2 capture, utilization and storage (CCUS) technology and the ecological environment. This seriously restricts the large-scale implementation and application of the concepts, technologies and projects of geological storage. China should expeditiously strengthen the scientific and technological research and development of coal mine “three wastes” geological storage technology and ecological environment synergistic development. Through the establishment of improved standards and norms, increased technological research and development, and strengthened environmental supervision and other measures, the green and sustainable development in China’s coal mines is promoted, helping the China’s “dual-carbon” goal to be realized

    Virus-Free and Live-Cell Visualizing SARS-CoV-2 Cell Entry for Studies of Neutralizing Antibodies and Compound Inhibitors

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    新型冠状病毒SARS-CoV-2在全球蔓延,给全球公共卫生带来严重威胁。快速研制疫苗、抗体和治疗药物成为科学界面临的重大挑战。由于SARS-CoV-2的高度传染性,采用病毒感染模型进行中和抗体及小分子抑制剂的药效评估需要在高等级生物安全实验室中进行,且常需要数天时间才能完成检测,限制了抗体和药物筛选的效率。发展快速、可视、不依赖于活病毒的新冠病毒入胞检测探针和细胞模型,对于加速新冠病毒抗体和药物的研究有重要意义。夏宁邵教授团队通过CHO真核表达系统高效表达制备出C端融合抗酸荧光蛋白Gamillus的重组新冠病毒spike蛋白STG。STG经SEC分子筛和冷冻电镜确认呈现与天然病毒刺突高度相似的三聚体结构,且与ACE2有很高的亲和力(18.2nM)。STG具备良好的细胞相容性和荧光性质,研究者进一步开发了可定量测定感染恢复期血清、疫苗免疫血清中和抗体(入胞阻断抗体)水平的CSBT检测方法。除了抗体检测评估方面的应用外,该研究发展的探针和模型还可用于筛选分析抑制新冠病毒入胞及胞内转运的小分子化合物。 我校博士后张雅丽,博士生王邵娟、巫洋涛,博士后侯汪衡、袁伦志和深圳市第三人民医院沈晨光博士为共同第一作者。厦门大学夏宁邵教授、袁权教授、程通教授为该论文共同通讯作者。The ongoing corona virus disease 2019 (COVID-19) pandemic, caused by SARS-CoV-2 infection, has resulted in hundreds of thousands of deaths. Cellular entry of SARS-CoV-2, which is mediated by the viral spike protein and ACE2 receptor, is an essential target for the development of vaccines, therapeutic antibodies, and drugs. Using a mammalian cell expression system,a genetically engineered sensor of fluorescent protein (Gamillus)-fused SARS-CoV-2 spike trimer (STG) to probe the viral entry process is developed.In ACE2-expressing cells, it is found that the STG probe has excellent performance in the live-cell visualization of receptor binding, cellular uptake, and intracellular trafficking of SARS-CoV-2 under virus-free conditions. The new system allows quantitative analyses of the inhibition potentials and detailed influence of COVID-19-convalescent human plasmas, neutralizing antibodies and compounds, providing a versatile tool for high-throughput screening and phenotypic characterization of SARS-CoV-2 entry inhibitors. This approach may also be adapted to develop a viral entry visualization system for other viruses.This study was supported by National Natural Science Foundation of China (81993149041 for N.X.; 81902057 for Y.Z.; 81871316 and U1905205 for Q.Y.), the National Science and Technology Major Project of Infectious Diseases (No. 2017ZX10304402‐002‐003 for T.C. and No. 2017ZX10202203‐009 for Q.Y.), the National Science and Technology Major Projects for Major New Drugs Innovation and Development (No. 2018ZX09711003‐005‐003 for T.C.), the Science and Technology Major Project of Fujian (2020YZ014001), the Science and Technology Major Project of Xiamen (3502Z2020YJ01), and the Guangdong Basic and Applied Basic Research Foundation (2020A1515010368 for C.S.). 该研究得到了国家自然科学基金、传染病防治国家科技重大专项、福建省应急科技攻关项目和厦门应急科技攻关项目的支持

    A Rapid Beam Pointing Determination and Beam-Pointing Error Analysis Method for a Geostationary Orbiting Microwave Radiometer Antenna in Consideration of Antenna Thermal Distortions

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    When observing the Earth’s radiation signal with a geostationary orbiting (GEO) mechanically scanned microwave radiometer, it is necessary to correct the antenna beam pointing (ABP) in real time for the deviation caused by thermal distortions of antenna reflectors with the help of the on-board Image Navigation and Registration (INR) system during scanning of the Earth. The traditional ABP determination and beam-pointing error (BPE) analysis method is based on the electromechanical coupling principle, which usurps time and computing resources and thus cannot meet the requirement for frequent real-time on-board INR operations needed by the GEO microwave radiometer. For this reason, matrix optics (MO), which is widely used in characterizing the optical path of the visible/infrared sensor, is extended to this study so that it can be applied to model the equivalent optical path of the microwave antenna with a much more complicated configuration. Based on the extended MO method, the ideal ABP determination model and the model for determining the actual ABP affected by reflector thermal distortions are deduced for China’s future GEO radiometer, and an MO-based BPE computing method, which establishes a direct connection between the reflector thermal distortion errors (TDEs) and the thermally induced BPE, is defined. To verify the overall performance of the extended MO method for rapid ABP determination, the outputs from the ideal ABP determination model were compared to calculations from GRASP 10.3 software. The experimental results show that the MO-based ABP determination model can achieve the same results as GRASP software with a significant advantage in computational efficiency (e.g., at the lowest frequency band of 54 GHz, our MO-based model yielded a 4,730,000 times faster computation time than the GRASP software). After validating the correctness of the extended MO method, the impacts of the reflector TDEs on the BPE were quantified on a case-by-case basis with the help of the defined BPE computing method, and those TDEs that had a significant impact on the BPE were therefore identified. The methods and results presented in this study are expected to set the basis for the further development of on-board INR systems to be used in China’s future GEO microwave radiometer and benefit the ABP determination and BEP analysis of other antenna configurations to a certain extent

    Does social capital influence individuals’ repayment default? Evidence from consumers\u27 behavior data with mobile phone

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    Our research mainly uses social capital theory as our theoretical basis to investigate the effect of mobile phone activities on individuals’ repayment delinquency in online peer-to-peer lending. We propose that individuals’ mobile phone activities mainly include making (receiving) phone call, surfing online, interacting in social media, and changing (registering) phone numbers. We collected data from 10 online peer-to-peer lending in Indonesia. The results show that the number of calls, the registration time of mobile phone number and loan default show a significant negative correlation, while the number of traffic recharge, whether to install social app, the number of mobile phone number change and loan default show a significant positive correlation. This suggests that not all increases in social capital improve repayment performance. If individuals have more BOS, they are more likely to repay their debts on time

    Study on Intelligent Monitoring Technology for Composting of Agricultural and Livestock Wastes

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    International audienceComposting is a harmless treatment process of agricultural and livestock wastes are widely used for grass-roots livestock farms. Composting temperature control is the key technical condition in composting process. In most current production process, the mechanical artificial temperature measuring devices were adopted to measure the composting temperature, which could not monitor the composting process resulting in the dumping delay. Meanwhile, the pathogenic microorganisms in compost could not be inactivated effectively. To solve this problem, an intelligent monitoring device was designed to realize the on-line monitoring of the whole process of composting. Users can query the compost temperature in real time by smart phone so as to dump in time to improve the inactivation efficiency of pathogenic microorganisms and reduce the loss of compost nutrients. The composting monitoring experiments showed that the system could monitor the composting process on-line and will have broad application in the field of livestock waste recycling

    Analysis of the Application and Benefits of Aircraft Electric Wheel Systems during Taxi and Take-Off

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    An electric wheel hybrid power system is designed for driving a large single-aisle passenger aircraft during the take-off and ground taxi phases, which consists of an APU, an energy storage system, and a motor. In the taxi phase, the electric wheel hybrid power system works alone, and the turbofan engine does not work, reducing fuel consumption and pollution emissions. During the take-off rolling phase, the electric wheel hybrid power system and turbofan engine work together to reduce the thrust requirement of the turbofan engine. This article establishes an aircraft kinematic model, hybrid power system model, and a mechanical wheel model. The feasibility of the collaborative work of the electric wheels and the turbofan engines is verified by simulations. By utilizing the established hybrid system of electric motor wheels, the fuel consumption can be reduced, and the emissions of CO, HC, and NOX can also be diminished to varying degrees. The input of motor power leads to lower turbine inlet temperature, thereby enhancing the turbofan engine’s service life by approximately 4.3% and saving operational costs
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