Electronic band reconstruction across the insulator-metal transition in colossal magnetoresistive EuCd2P2

While colossal magnetoresistance (CMR) in Eu-based compounds is often associated with strong spin-carrier interactions, the underlying reconstruction of the electronic bands is much less understood from spectroscopic experiments. Here using angle-resolved photoemission, we directly observe an electronic band reconstruction across the insulator-metal (and magnetic) transition in the recently discovered CMR compound EuCd2P2. This transition is manifested by a large magnetic band splitting associated with the magnetic order, as well as unusual energy shifts of the valence bands: both the large ordered moment of Eu and carrier localization in the paramagnetic phase are crucial. Our results provide spectroscopic evidence for an electronic structure reconstruction underlying the enormous CMR observed in EuCd2P2, which could be important for understanding Eu-based CMR materials, as well as designing CMR materials based on large-moment rare-earth magnets.Comment: 6 pages, 4 figure

Pilot Contamination Mitigation via a Novel Time-Shift Pilot Scheme in Large-Scale Multicell Multiuser MIMO Systems

We propose a novel time-shift pilot scheme to mitigate the pilot contamination in large-scale multicell multiuser MIMO (LS-MIMO) systems. In the proposed scheme, the length of the uplink training pilot sequence is equal to the cell number; that is to say, the same pilot sequence is used within a cell, while for different cells, pilot sequences are mutually orthogonal. Moreover, users within a cell transmit the same pilot sequence in a time-shift manner during the channel estimation stage and in this way all user terminals’ channel state information can be estimated without contamination. The asymptotic channel orthogonality is studied in the LS-MIMO system, with which the mutual interference among cells caused by data and pilot sequences can be cancelled with the successive interference cancellation (SIC) method. We explore the superiority of the proposed scheme in channel coefficient estimation, uplink data detection, and downlink data transmission steps. Theoretical analysis and simulation results demonstrate that the proposed time-shift pilot design can alleviate the pilot contamination problem and improve the performance of the considered system significantly compared with the popular orthogonal pilots

An Image Segmentation Method Combining L1-Sparse Reconstruction with Spectral Clustering

AbstractThe Normalized Cut method has been proposed to serve as an effective image segmentation method. Nevertheless, the image segmentation result of the Normalized Cut method is sometimes unsatisfactory. In this paper, we propose an improved image segmentation method combining L1-sparse reconstruction with the Normalized Cut method. Experimental results show that the improved method not only retains the advantages of the Normalized Cut method, but also overcomes the drawbacks of its over-segmentation or incomplete segmentation under certain conditions

Sensing Fractional Power Spectrum of Nonstationary Signals with Coprime Filter Banks

The coprime discrete Fourier transform (DFT) filter banks provide an effective scheme of spectral sensing for wide-sense stationary (WSS) signals in case that the sampling rate is far lower than the Nyquist sampling rate. And the resolution of the coprime DFT filter banks in the Fourier domain (FD) is 2π/MN, where M and N are coprime. In this work, a digital fractional Fourier transform- (DFrFT-) based coprime filter banks spectrum sensing method is suggested. Our proposed method has the same sampling principle as the coprime DFT filter banks but has some advantages compared to the coprime DFT filter banks. Firstly, the fractional power spectrum of the chirp-stationary signals which are nonstationary in the FD can be sensed effectively by the coprime DFrFT filter banks because of the linear time-invariant (LTI) property of the proposed system in discrete-time Fourier domain (DTFD), while the coprime DFT filter banks can only sense the power spectrum of the WSS signals. Secondly, the coprime DFrFT filter banks improve the resolution from 2π/MN to 2π sin α/MN by combining the fractional filter banks theory with the coprime theory. Simulation results confirm the obtained analytical results

Therapeutic Effect of Polysaccharide of Large Yellow Croaker Swim Bladder on Lupus Nephritis of Mice

The therapeutic effect of polysaccharide of large yellow croaker swim bladder (PLYCSB) on lupus nephritis has been studied in vivo. A high concentration (50 mg/kg dose) of PLYCSB reduced the levels of serum inflammatory cytokine levels of IL-6, IL-12, TNF-α and IFN-γ compared to a low concentration (25 mg/kg dose) and control mice. SCr, BUN, TC and TG serum levels of PLYCSB treated mice were lower than those of control mice, and TP and ALB serum levels were higher than control mice. Control mice tested ds-DNA positive at the 6th week, and 50 mg/kg treated mice tested at the 10th week after the experiment began. The output of urine protein of 50 mg/kg PLYCSB treated mice was most closely comparable to the normal mice. The glomerular number of 50 mg/kg PLYCSB treated mice was more than the 25 mg/kg dose and control groups, and the 50 mg/kg dose group showed the lowest glomerular sclerosis index in lupus nephritis mice. By RT-PCR and western blot assay, PLYCSB significantly induced inflammation in kidney tissues of mice by downregulating NF-κB-p65, TGF-β1, Fas, FasL and upregulating IκB-α. These results suggest that PLYCSB showed a potential curative effect on lupus nephritis as a drug or functional food

The roles of neutrophil serine proteinases in idiopathic inflammatory myopathies

Abstract Background Dermatomyositis and polymyositis are the best known idiopathic inflammatory myopathies (IIMs). Classic histopathologic findings include the infiltration of inflammatory cells into muscle tissues. Neutrophil serine proteinases (NSPs) are granule-associated enzymes and play roles in inflammatory cell migration by increasing the permeability of vascular endothelial cells. In this study, we aimed to find the roles of NSPs in pathogenesis of IIMs. Methods RNA and DNA were isolated to measure the relative expression of NSPs and their methylation levels. The expression of NSPs in serum and muscle tissues was tested by enzyme-linked immunosorbent assay, immunohistochemistry, and immunofluorescence, respectively. Serum from patients was used to culture the human dermal microvascular endothelial cells (HDMECs), and then we observed the influence of serum on expression of VE-cadherin, endothelial cell tube formation, and transendothelial migration of peripheral blood mononuclear cells (PBMCs). Results We found that the expression of NSPs was increased in PBMCs, serum, and muscle tissues of IIM patients; these NSPs were hypomethylated in the PBMCs of patients. Serum NSPs were positively correlated with clinical indicators of IIM patients, including lactic dehydrogenase, erythrocyte sedimentation rate, C-reactive protein, immunoglobulin G, immunoglobulin M, and immunoglobulin A. Patients with anti-Jo-1, with anti-Ro-52, or without interstitial lung disease had lower levels of proteinase 3. Serum NSPs degraded the VE-cadherin of HDMECs, and serum NSP application increased the permeability of HDMECs. Conclusions Our studies indicate, for the first time, that NSPs play an important role in muscle inflammatory cell infiltration by increasing the permeability of vascular endothelial cells in IIM patients

Combined Adenovirus-Mediated Artificial microRNAs Targeting mfgl2, mFas, and mTNFR1 Protect against Fulminant Hepatic Failure in Mice

<div><p>Hepatitis B virus (HBV)-related acute-on-chronic liver failure (ACLF) has a poor prognosis with high in-hospital mortality. Hepatic and circulating inflammatory cytokines, such as fibrinogen like protein 2 (fgl2), FasL/Fas, and TNFα/TNFR1, play a significant role in the pathophysiology of ACLF. This study aimed to investigate the therapeutic effect of recombinant adenoviral vectors carrying constructed DNA code for non-native microRNA (miRNA) targeting mouse fgl2 (mfgl2) or both mFas and mTNFR1 on murine hepatitis virus (MHV)-3-induced fulminant hepatitis in BALB/cJ mice. Artificial miRNA eukaryotic expression plasmids against mfgl2, mFas, and mTNFR1 were constructed, and their inhibitory effects on the target genes were confirmed <i>in vitro</i>. pcDNA6.2-mFas-mTNFR1- miRNA，which expresses miRNA against both mFas and mTNFR1 simultaneously，was constructed. To construct a miRNA adenovirus expression vector against mfgl2, pcDNA6.2-mfgl2-miRNA was cloned using Gateway technology. Ad-mFas-mTNFR1- miRNA was also constructed by the same procedure. Adenovirus vectors were delivered by tail-vein injection into MHV-3-infected BALB/cJ mice to evaluate the therapeutic effect. 8 of 18 (44.4%) mice recovered from fulminant viral hepatitis in the combined interference group treated with Ad-mfgl2-miRNA and Ad-mFas-mTNFR1-miRNA. But only 4 of 18 (22.2%) mice receiving Ad-mfgl2-miRNA and 3 of 18 (16.7%) mice receiving Ad-mFas-mTNFR1- miRNA survived. These adenovirus vectors significantly ameliorated inflammatory infiltration, fibrin deposition, hepatocyte necrosis and apoptosis, and prolonged survival time. Our data illustrated that combined interference using adenovirus-mediated artificial miRNAs targeting mfgl2, mFas, and mTNFR1 might have significant therapeutic potential for the treatment of fulminant hepatitis.</p> </div