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    Presencia de n贸dulos tiroideos en pacientes con s铆ndrome metab贸lico en un hospital de tercer nivel de atenci贸n peruano

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    ABSTRACT: Objective : To compare the frequency of thyroid node disease (TND) in patients with metabolic syndrome (MS) and in patients without metabolic syndrome in an area with good iodine supply. Materials and Methods : This is an analytical comparative case- control study performed in paired groups. There were 40 patients with MS and 40 controls attending the Endocrinology service in Cayetano Heredia Hospital in Lima, Peru, who were paired according to age and sex. Weight, height, and blood pressure measurements were taken from clinical records. Abdominal circumference was measured, and the presence of acanthosis nigricans was determined. Lipid profile, baseline blood glucose and TSH were determined. Thyroid ultrasonography was performed in all participants. Thyroid volume values were recorded and thyroid nodes measuring >5-mm were considered as clinically significant. Results : Eighty per cent of the studied population in both groups was women. There were significant differences in tobacco use, acanthosis nigricans, TSH levels, thyroid volume, weight, body mass index, abdominal circumference, diastolic blood pressure, baseline blood glucose, HDL-cholesterol and triglyceride levels between both groups. TND was more frequent in those patients with MS compared to patients with no MS (40% vs. 12.5%, respectively; p= 0.015). The odds ratio (OR) for having thyroid nodes in the presence of MS was 4.66 (95% confidence interval: 1.34-16.24). There were significant differences in thyroid volume for both groups (p= 0.039). Conclusion : In an area with good iodine supply, MS was associated to TND to with an increased thyroid volume.RESUMEN Objetivo: comparar la frecuencia de enfermedad nodular tiroidea (ENT) en pacientes con s铆ndrome metab贸lico (SM) y en pacientes sin SM en un 谩rea yodosuficiente. Materiales y m茅todos: estudio anal铆tico, de casos y controles, comparativo de grupos pareados. Fueron 40 pacientes con SM y 40 controles, pareados por edad y sexo, los cuales acudieron al servicio de Endocrinolog铆a del Hospital Cayetano Heredia, Lima - Per煤. El peso, talla y la presi贸n arterial fueron tomadas de la historia cl铆nica. Se evalu贸 el per铆metro abdominal y la presencia de acantosis nigricans. Se midi贸 perfil lip铆dico, glucosa basal y TSH. Se realiz贸 ecograf铆a tiroidea a todos los participantes. Se midi贸 el volumen tiroideo y se consider贸 cl铆nicamente significativo a n贸dulos tiroideos > 5 mm. Resultados: el 80 % de la poblaci贸n estudiada en ambos grupos fueron mujeres. Hubo diferencias significativas en el h谩bito tab谩quico, la acantosis nigricans, la TSH, el volumen tiroideo, peso, 铆ndice de masa corporal, per铆metro abdominal, presi贸n diast贸lica, glucosa basal, HDL-colesterol y triglic茅ridos entre ambos grupos. La ENT fue m谩s frecuente en los pacientes con SM que en los pacientes sin SM (40% vs. 12,5% respectivamente, p = 0,015). El odds ratio (OR) para presentar n贸dulos tiroideos en presencia de SM fue de 4,66 (intervalo de confianza al 95%: 1,34 - 16,24). Hubo diferencia significativa en el volumen tiroideo entre ambos grupos (p = 0,039). Conclusi贸n: en una poblaci贸n de una zona yodosuficiente, el SM estuvo asociado a ENT y al incremento del volumen tiroideo
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