(Z)-2-[(2,4-Dimethyl­phen­yl)imino]-1,3-thia­zinan-4-one

In the title compound, C12H14N2OS, the 1,3-thia­zinane ring displays a screw-boat conformation. In the crystal, pairs of centrosymmetrically related mol­ecules are linked by pairs of N—H⋯O hydrogen bonds into dimers. C—H⋯π inter­actions occur between adjacent dimers

(Z)-4-[(2-Amino­anilino)(phen­yl)methyl­idene]-3-methyl-1-phenyl-1H-pyrazol-5(4H)-one

The mol­ecule of the title compound, C23H20N4O, assumes a non-planar conformation in which the pyrazolone ring forms dihedral angles of 10.33 (11), 65.34 (11) and 63.52 (10)° with the three benzene rings. In the crystal, the mol­ecules are linked by inter­molecular N—H⋯N hydrogen bonds, generating chains parallel to the b axis. The secondary amino group is involved in an intra­molecular N—H⋯O hydrogen bond

Plant Age Effect on Mechanical Properties of Moso Bamboo (Phyllostachys Heterocycla Var. Pubescens) Single Fibers

Bamboo fiber has greater mechanical strength than certain other natural fibers and could therefore be a candidate for production of fiber-reinforced composites. Single fibers were isolated from Moso bamboo samples taken from plants between 0.5 and 8.5 yr old. Mechanical properties of single fibers (tensile strength, modulus of elasticity (MOE), and other mechanical related properties such as the microfibril angle and fiber cross-sectional area) were studied. There was no significant variation with age in average MOE and fracture strain of the bamboo fibers. Results indicate that the thickening growth of cell walls in bamboo fibers near the outer surface of bamboo is almost complete by 0.5 yr. Therefore, fibers from 0.5 to 8.5 yr old plants may be used for making fiber-reinforced composites

Expression and prognostic significance of Golgiglycoprotein73 (GP73) with Epithelial-mesenchymal transition (EMT) related molecules in Hepatocellular Carcinoma (HCC)

BACKGROUND: Hepatocellular carcinoma (HCC) is the fifth most common cancer and the third cause of cancer-related deaths, worldwide. It is essential to develop an effective prognostic biomarker and determine the mechanisms underlying HCC invasion and metastasis. AIMS: This study aimed to investigate the expression of Golgi glycoprotein73 (GP73) and Epithelial-mesenchymal transition (EMT) molecules such as E-cadherin and Vimentin in HCC. We also evaluated the prognostic value of GP73 in HCC. METHODS: Immunohistochemistry (IHC) was used to determine the expression of GP73 and EMT molecules in 75 HCC specimens and the corresponding paracarcinomatous liver (PCL) tissues. Spearman’s correlation test was used to analyze the correlation of GP73 and EMT molecules. Clinicopathological features of the HCC patients were also analyzed. Univariate survival analysis was performed by the Kaplan–Meier method and differences among the groups were analyzed by the Log-rank test. RESULTS: GP73 expression in HCC was higher compared with PCL tissues (χ( 2 ) = 73.60, P < 0.05). EMT molecules were also detected in HCC and PCL tissues. GP73 was negatively correlated with E-cadherin (r = − 0.49, P < 0.05), but positively correlated with Vimentin (r = 0.46, P < 0.05) in HCC. GP73 was correlated with the clinicopathological features including Edmondson grade, vascular invasion and TNM stage (P < 0.05), which was also associated with overall survival (OS) (P < 0.05). CONCLUSIONS: GP73 was negatively with E-cadherin and positively correlated with Vimentin. It might be associated with aggressive behavior of HCC and had influence on patients’ OS. Further research is needed to determine the potential of GP73. VIRTUAL SLIDES: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/29 vs/1504046946108618; http://med.motic.com/MoticGallery/Slide?id=3b6a037e-f60e-4c68-9106-41e790de9431&user=2C69F0D6-A478-4A2B-ABF0-BB36763E8025; http://med.motic.com/MoticGallery/Slide?id=a25b5b32-b613-47b0-9f8b-e1e67a95d1bf&user=2C69F0D6-A478-4A2B-ABF0-BB36763E8025

1,1′-(2-Thienylmethylene)di-2-naphthol ethyl acetate solvate

In the title compound, C25H18O2S·C4H8O2, there are inter­molecular O—H⋯O hydrogen bonds between the main mol­ecule and the solvent molecule. The thio­phene ring is oriented at dihedral angles of 70.87 (7) and 75.36 (4)° with respect to the mean planes of the two naphthyl ring systems

Structure and superconductivity of Mg(B1-xCx)2 compounds

In this paper, we reported the structural properties and superconductivity of Mg(B1-xCx)2 compounds. Powder x-ray diffraction results indicate that the samples crystallize in a hexagonal AlB2-type structure. Due to the chemical activity of Mg powders, a small amount of MgO impurity phase was detected by x-ray diffraction. The lattice parameters decrease slightly with increasing carbon content. Magnetization measurements indicate the non-stoichiometry of MgB2 has no influence on the superconducting transition temperature and the transition temperature width. The addition of carbon results in a decrease of Tc and an increase in the superconducting transition width, implying the loss of superconductivity.Comment: PDF files, 5 pages,3 figures, Accepted by Chinese Physics on Feb. 26, 2001(in press

Effect of insulin and metformin on methylation and glycolipid metabolism of peroxisome proliferator-activated receptor γ coactivator-1A of rat offspring with gestational diabetes mellitus

AbstractObjectiveTo discuss the effect of insulin and metformin on a methylation and glycolipid metabolism of peroxisome proliferator-activated receptor γ coactivator-1A (PPARGC1A) of rat offspring with gestational diabetes mellitus (GDM).MethodsA total of 45 pregnant rats received the intraperitoneal injection of streptozotocin to establish the pregnant rat model of GDM. A total of 21 pregnant rats with GDM were randomly divided into three groups, with 7 rats in each group, namely the insulin group, metformin group and control group. Rats in the insulin group received the abdominal subcutaneous injection of 1 mL/kg recombinant insulin glargine at 18:00 every day. Rats in the metformin group received the intragastric infusion of metformin hydrochloride at 18:00 every day, with the first dose of 300 mg/kg. The doses of two groups were adjusted every 3 d to maintain the blood glucose level at 2.65–7.62 mmol/L. Rats in the control group received the intragastric infusion of 1 mL normal saline at 18:00 every day. After the natural delivery of pregnant rats, 10 offspring rats were randomly selected from each group. At birth, 4 wk and 8 wk after the birth of offspring rats, the weight of offspring rats was measured. The blood glucose level of offspring rats was measured at 4 wk and 8 wk, while the level of serum insulin, triglyceride and leptin was measured at 8 wk.ResultsThe weight of offspring rats at birth in the insulin group and metformin group was significantly lower than the one in the control group (P < 0.05), and there was no significant difference at 4 wk and 8 wk among three groups (P > 0.05). The fasting blood glucose and random blood glucose in the insulin group and metformin group at 4 wk and 8 wk were all significantly lower than ones in the control group (P < 0.05); there was no significant difference between the insulin group and metformin group (P > 0.05). The expression of PPARGC1A mRNA in the insulin group and metformin group was significantly higher and the methylation level of PPARGC1A was significantly lower than the one in the control group (P < 0.05); but there was no significant difference between the insulin group and metformin group (P > 0.05). Insulin and leptin at 8 wk in the insulin group and metformin group were significantly higher, while triglyceride was significantly lower than the one in the control group (P < 0.05); triglyceride level in the insulin group was significantly higher than the one in the metformin group (P < 0.05). There was no significant difference in insulin and leptin level between the insulin group and metformin group (P > 0.05).ConclusionsGDM can induce the methylation of PPARGC1A of offspring rats to reduce the expression of PPARGC1A mRNA and then cause the disorder of glycolipid metabolism when the offspring rats grow up; the insulin or metformin in the treatment of pregnant rats with GDM can reduce the methylation level of PPARGC1A and thus improve the abnormal glycolipid metabolism of offspring rats