Palladium-Catalyzed Domino Synthesis of 4‑Amino-3-acyl-2- naphthols via Isocyanide Chemoselective Insertion

A novel and efficient strategy for the synthesis of sterically hindered 4-amino-3-acyl-2-naphthols through a palladium-catalyzed coupling reaction involving isocyanide chemselective insertion and domino isomerization has been developed. The methodology, which is in accordance with the principle of “atom and step economy”, efficiently constructs 4-amino-3-acyl-2-naphthols in moderate to good yields