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Palladium-Catalyzed Domino Synthesis of 4‑Amino-3-acyl-2- naphthols via Isocyanide Chemoselective Insertion
A novel and efficient strategy for
the synthesis of sterically
hindered 4-amino-3-acyl-2-naphthols through a palladium-catalyzed
coupling reaction involving isocyanide chemselective insertion and
domino isomerization has been developed. The methodology, which is
in accordance with the principle of “atom and step economy”,
efficiently constructs 4-amino-3-acyl-2-naphthols in moderate to good
yields