2-Amino-4,6-dimethyl­pyrimidinium chloro­acetate

There are two cations and two anions in the asymmetric unit of the title compound, C6H10N3 +·C2H2ClO2 −. In the crystal, the components are linked by inter­molecular N—H⋯O and N—H⋯N hydrogen bonds to form a two-dimensional network. Additional stabilization is provided by weak inter­molecular C—H⋯O inter­actions

Efficacy and safety of latanoprost versus timolol for primary open angle glaucoma and ocular hypertension: a Meta-analysis

AIM: To evaluate the efficacy and safety of latanoprost versus timolol for primary open angle glaucoma(POAG)and ocular hypertension(OHT).<p>METHODS: This was an evidence-based medicine science study. Pertinent studies of randomized controlled trial(RCT)were identified through searches of PubMed, Medline, CNKI and China Biology Medicine disc. The intensive searching by hand and internet was also designed. According to inclusion and exclusion criteria, the study object was limited. Quality of literatures were evaluated by experienced researchers according to the Jadad Score. RevMan 5.0 offered by Cochrane was used for Meta-analysis aimed at the ratio of low intraocular tension and adverse drug reaction.<p>RESULTS: A total of 9 RCT sadded up to 555 patients were involved. The results of meta-analysis showed that, a)the difference at 2, 6, 12wk both had statistical significance, latanoprost showed greater intraocular pressure(IOP)lowering efficacy compared with timolol. The weighted mean difference(WMD)at 2, 6, 12wk was respectively \〖-0.76, 95% <i>CI</i>(-1.32 to -0.20)\〗, \〖-1.15, 95% <i>CI</i>(-1.68 to 0.63)\〗 and \〖-1.01, 95% <i>CI</i>(-1.42 to -0.61)\〗. b)The difference in conjunctival congestion(<i>OR</i>=2.25, 95% <i>CI</i> 0.99 to 5.08)and foreign body sensation(<i>OR</i>=2.48, 95% <i>CI</i> 1.02 to 6.03 )between latanoprost and timolol group was not statistically significant. <p>CONCLUSION: Latanoprost showed greater IOP lowering efficacy at 12wk compared with timolol for OAG and OH patients. The conjunctival hyperemia, foreign body sensation, iris pigmentation deepened, vision damage of latanoprost group at 12wk compared with timolol, the difference was not significant. This conclusion is not powerful enough in proof due to the medium methodology quality of the included studies, so a large number of high-quality RCTs with large sample are needed for objectively, precisely and entirely evaluating the efficacy

Poly[[[bis­(acetato-κO)copper(II)]-μ-1,4-diimidazol-1-ylbenzene-κ2 N 3:N 3′] dihydrate]

In the title linear coordination polymer, {[Cu(C2H3O2)2(C12H10N4)]·2H2O}n, the CuII atom is coordinated by two N atoms from two different symmetry-related 1,4-diimidazol-1-ylbenzene (dib) ligands and two carboxyl­ate O atoms from two acetate ligands in a square-planar geometry. The Cu atoms are linked by the dib ligands, forming an extended chain. These chains are linked by O—H⋯O hydrogen bonds into a three-dimensional supra­molecular network. The CuII atom lies on a center of inversion

Poly[[tetra­aqua­tetra­kis­[μ3-5-(pyridine-4-carboxamido)­isophthalato]­cobalt(II)­diholmium(III)] tetra­hydrate]

In the centrosymmetric polymeric title compound, {[CoHo2(C14H8N2O5)4(H2O)4]·4H2O}n, the HoIII ion is coordinated by one water mol­ecule and four 5-(pyridine-4-carboxamido)­isophthalate (L) ligands in a distorted square-anti­prismatic arrangement. The CoII ion, located on an inversion center, is coordinated by two pyridine N atoms, two carboxyl­ate O atoms and two water mol­ecules in a distorted octa­hedral geometry. One L ligand bridges two Ho ions and one Co ion through two carboxyl­ate groups and one pyridine N atom. The other L ligand bridges two Ho ions and one Co ion through two carboxyl­ate groups, while the uncoordinated pyridine N atom accepts a hydrogen bond from an adjacent coordinated water mol­ecule. Extensive O—H⋯O, N—H⋯O and O—H⋯N hydrogen bonding is present in the crystal

The effect of early and intensive statin therapy on ventricular premature beat or non-sustained ventricular tachycardia in patients with acute coronary syndrome

Background: Our study&#8217;s aim was to evaluate the prognostic value of early and intensive lipid-lowering treatment on ventricular premature beat or non-sustained ventricular tachycardia (NSVT) after acute coronary syndrome (STEMI, non-STEMI, and unstable angina pectoris). Methods: Some 586 patients with acute coronary syndrome were randomly divided into two groups: Group A (with conventional statin therapy, to receive 10 mg/day atorvastatin, n = 289) and Group B (given early and intensive statin therapy, 60 mg immediately and 40 mg/day atorvastatin, n = 297). The frequency of ventricular premature beat and NSVT was recorded via Holter monitoring after hospitalization (24 h and 72 h). Results: Seventy seven (11.8%) patients had NSVT. When compared to patients with no documented NSVT, patients with NSVT were older and more frequently had myocardial infarction in their history, diabetes mellitus, atrial fibrillation and an ejection fraction < 40%. Ventricular premature beats decreased significantly in the early and aggressive treatment group (24 h, p < 0.01; 72 h, p < 0.001). A significant reduction in NSVT was seen in the early and aggressive treatment group (24 h, p < 0.01; 72 h, p < 0.001). There were no side effects observed in either group. Conclusions: Early and intensive lipid-lowering treatment can clearly decrease ventricular premature beats and NSVT. (Cardiol J 2010; 17, 4: 381-385

Hybrid Particle and Kalman Filtering for Pupil Tracking in Active IR Illumination Gaze Tracking System

A novel pupil tracking method is proposed by combining particle filtering and Kalman filtering for the fast and accurate detection of pupil target in an active infrared source gaze tracking system. Firstly, we utilize particle filtering to track pupil in synthesis triple-channel color map (STCCM) for the fast detection and develop a comprehensive pupil motion model to conduct and analyze the randomness of pupil motion. Moreover, we built a pupil observational model based on the similarity measurement with generated histogram to improve the credibility of particle weights. Particle filtering can detect pupil region in adjacent frames rapidly. Secondly, we adopted Kalman filtering to estimate the pupil parameters more precisely. The state transitional equation of the Kalman filtering is determined by the particle filtering estimation, and the observation of the Kalman filtering is dependent on the detected pupil parameters in the corresponding region of difference images estimated by particle filtering. Tracking results of Kalman filtering are the final pupil target parameters. Experimental results demonstrated the effectiveness and feasibility of this method.Published versio