Health Score Criteria.

<p>Health Score Criteria.</p

Effects of OXA on genes related to the insulin signaling pathway in skeletal muscle.

<p><i>db/db</i> mice received the vehicle and OXA (750 mg/kg of body weight) for 12 weeks. Then, skeletal muscle was dissected.and the expressions of genes related to the insulin signaling pathway were measured by PCR array. Fold changes of the skeletal muscle genes in OXA-treated <i>db/db</i> mice compared with vehicle-treated <i>db/db</i> mice. *<i>p</i> < 0.05 and **<i>p</i> < 0.01 as compared to the vehicle-treated <i>db/db</i> mice (unpaired, two-tail Student’s <i>t</i>-test); (n = 3 for each group, the mRNA levels of all genes were normalized by β-actin). Abbreviated names for the genes are presented in red. Numbers (in black) represent fold-changes. A (in blue): This gene's average threshold cycle was > 30 in the control or the test sample, and was reasonably < 30 in the other sample. B (in blue): This gene's average threshold cycle was > 30, which means that the level of gene expression was relatively low in both samples, and the P-value for the fold-change was unavailable or high (<i>P</i> > 0.05). C (in blue): This gene's average threshold cycle was not determined or was > 35 (cut-off value) in both samples, indicating that gene expression was undetected, and the result was erroneous and non-interpretable. “OKAY” means that this gene's average threshold cycle was < 30 in both samples, and the result was accepted.</p

The Prognostic Role of the Platelet-Lymphocytes Ratio in Gastric Cancer: A Meta-Analysis - Fig 3

<p><b>Forrest plots (A), sensitivity analyses (B) of included studies evaluating HR of PLR for OS.</b> OS = overall survival, CI = confidence interval, IV = inverse variance, SE = standard error.</p

Characteristics of included studies in meta-analysis.

<p>Characteristics of included studies in meta-analysis.</p

Subgroup analyses results.

<p>Subgroup analyses results.</p

Literature screening flow chart and results.

<p>doi:<a href="http://dx.doi.org/10.1371/journal.pmed1000097" target="_blank">10.1371/journal.pmed1000097</a>.</p

Effects of OXA on LDH-A expression in islets.

<p>Liver, adipose, skeletal muscle, and pancreas tissue from 4-week-old <i>db/+</i> mice, and pancreas tissue from the mice after a treatment (vehicle, OXA, and PIO) of 12 weeks were dissected and LDH-A staining was performed (×200). (A) Liver from 4-week-old <i>db/+</i> mice; (B) adipose tissue from 4-week-old <i>db/+</i> mice; (C) skeletal muscle from 4-week-old <i>db/+</i> mice; (D) pancreas from 4-week-old <i>db/+</i> mice; (E) pancreas from vehicle <i>db/+</i> mice; (F) pancreas from vehicle <i>db/db</i> mice; (G) pancreas from <i>db/db</i> mice treated with OXA of 350 mg/kg of body weight; (H) pancreas from <i>db/db</i> mice treated with OXA of 750 mg/kg of body weight; (I) pancreas from <i>db/db</i> mice treated with PIO of 100 mg/kg of body weight. OXA: oxamate; PIO: pioglitazone.</p

Effects of OXA on islet morphology and insulin expression.

<p><i>db/+</i> mice received the vehicle (0.9% NaCl), and <i>db/db</i> mice received the vehicle and OXA (350 and 750 mg/kg of body weight) or PIO (100 mg/kg of body weight) respectively for 12 weeks. Then, the pancreas was dissected and insulin staining was performed (×200). (A) pancreas from vehicle <i>db/+</i> mice; (B) pancreas from vehicle <i>db/db</i> mice; (C) pancreas from <i>db/db</i> mice treated with OXA of 350 mg/kg of body weight; (D) pancreas from <i>db/db</i> mice treated with OXA of 750 mg/kg of body weight; (E) pancreas from <i>db/db</i> mice treated with PIO of 100 mg/kg of body weight. OXA: oxamate; PIO: pioglitazone.</p

Effects of OXA on serum HbA1c levels.

<p><i>db/+</i> mice received the vehicle (0.9% NaCl), and <i>db/db</i> mice received the vehicle and OXA (150, 350, 550, 750 mg/kg of body weight) or PIO (100 mg/kg of body weight) respectively for 12 weeks. Then, an 8-h fasting blood sample was collected for the detection of HbA1c levels. Results are expressed as the mean ± SD, n = 5. OXA: oxamate; PIO: pioglitazone. **: <i>p</i> < 0.01 as compared to the vehicle <i>db/+</i> mice; #: <i>p</i> < 0.05 as compared to the vehicle <i>db/db</i> mice; ##: <i>p</i> < 0.01 as compared to the vehicle <i>db/db</i> mice (one-way ANOVA followed by Student-Newman-Keuls test).</p

Effects of OXA on fasting serum insulin levels.

<p><i>db/+</i> mice received the vehicle (0.9% NaCl), and <i>db/db</i> mice received the vehicle and OXA (150, 350, 550, 750 mg/kg of body weight) or PIO (100 mg/kg of body weight) respectively for 12 weeks. Then, an 8-h fasting blood sample was collected for the detection of insulin. Results are expressed as the mean ± SD, n = 5. OXA: oxamate; PIO: pioglitazone. **: <i>p</i> < 0.01 as compared to the vehicle <i>db/+</i> mice; ##: <i>p</i> < 0.01 as compared to the vehicle <i>db/db</i> mice (one-way ANOVA followed by Student-Newman-Keuls test).</p