MOESM2 of Lipid profiling of the therapeutic effects of berberine in patients with nonalcoholic fatty liver disease

Additional file 2: Figure S1. The line graph of the glucose tolerance test (0–3 h). Data were mean ± SD, LSI: lifestyle intervention, BBR plus LSI: berberine treatment plus lifestyle intervention. *P < 0.05 when comparing before and after berberine plus lifestyle intervention treatment, #P < 0.05 when comparing before and after lifestyle intervention alone treatment

ROC-curves of the Chinese NAFLD score to predict NAFLD in the estimation group, the internal Chinese validation group and the Finnish external validation group.

<p>In the estimation group, AUROC = 0.79 (0.77, 0.81),cut-off = -0.79, Specificity = 0.72, Sensitivity = 0.71. In the internal Chinese validation group, AUROC = 0.76 (0.73, 0.78), cut-off = -0.79, Specificity = 0.71, Sensitivity = 0.69. In the Finnish external validation group, AUROC = 0.74 (0.69, 0.80), cut-off = 0.68, Specificity = 0.62, Sensitivity = 0.79.</p

Multivariate logistic regression model to predict NAFLD in Chinese estimation group.

<p>Multivariate logistic regression model to predict NAFLD in Chinese estimation group.</p

Characteristics of the Chinese population and the Finnish external validation group.

<p>Characteristics of the Chinese population and the Finnish external validation group.</p

Univariate logistic regression showing odds ratios and 95%CI for NAFLD in the Chinese and Finns.

<p>Univariate logistic regression showing odds ratios and 95%CI for NAFLD in the Chinese and Finns.</p

Diagnostic performance of noninvasive prediction scores.

<p>Diagnostic performance of noninvasive prediction scores.</p

MOESM1 of Wenyang Huazhuo Tongluo formula inhibits fibrosis via suppressing Wnt/β-catenin signaling pathway in a Bleomycin-induced systemic sclerosis mouse model

Additional file 1. Minimum Standards of Reporting Checklist

MOESM1 of The association of liver fat content and serum alanine aminotransferase with bone mineral density in middle-aged and elderly Chinese men and postmenopausal women

Additional file 1. Program for liver fat content calculation based on ultrasonography quantitative method

Table_1_Characteristics of changes in plasma proteome profiling after sleeve gastrectomy.docx

Bariatric surgery (BS), recognized as the most effective intervention for morbid obesity and associated metabolic comorbidities, encompasses both weight loss-dependent and weight loss-independent mechanisms to exert its metabolic benefits. In this study, we employed plasma proteomics technology, a recently developed mass spectrometric approach, to quantitatively assess 632 circulating proteins in a longitudinal cohort of 9 individuals who underwent sleeve gastrectomy (SG). Through time series clustering and Gene Ontology (GO) enrichment analysis, we observed that complement activation, proteolysis, and negative regulation of triglyceride catabolic process were the primary biological processes enriched in down-regulated proteins. Conversely, up-regulated differentially expressed proteins (DEPs) were significantly associated with negative regulation of peptidase activity, fibrinolysis, keratinocyte migration, and acute-phase response. Notably, we identified seven proteins (ApoD, BCHE, CNDP1, AFM, ITIH3, SERPINF1, FCN3) that demonstrated significant alterations at 1-, 3-, and 6-month intervals post SG, compared to baseline. These proteins play essential roles in metabolism, immune and inflammatory responses, as well as oxidative stress. Consequently, they hold promising potential as therapeutic targets for combating obesity and its associated comorbidities.</p