243 research outputs found
Condensate cosmology -- dark energy from dark matter
Imagine a scenario in which the dark energy forms via the condensation of
dark matter at some low redshift. The Compton wavelength therefore changes from
small to very large at the transition, unlike quintessence or metamorphosis. We
study CMB, large scale structure, supernova and radio galaxy constraints on
condensation by performing a 4 parameter likelihood analysis over the Hubble
constant and the three parameters associated with Q, the condensate field:
Omega_Q, w_f and z_t (energy density and equation of state today, and redshift
of transition). Condensation roughly interpolates between Lambda CDM (for large
z_t) and sCDM (low z_t) and provides a slightly better fit to the data than
Lambda CDM. We confirm that there is no degeneracy in the CMB between H and z_t
and discuss the implications of late-time transitions for the Lyman-alpha
forest. Finally we discuss the nonlinear phase of both condensation and
metamorphosis, which is much more interesting than in standard quintessence
models.Comment: 13 pages, 13 colour figures. Final version with discussion of TE
cross-correlation spectra for condensation and metamorphosis in light of the
WMAP result
Eczema phenotypes and risk of allergic and respiratory conditions in school age children
Background: Eczema phenotypes based on eczema onset and persistence might better identify groups prone to allergic and respiratory conditions than a binary definition of eczema. We examined the associations of childhood eczema phenotypes with allergic sensitization, allergy, asthma and lung function at school age. Methods: This study among 4277 children was embedded in a multi-ethnic population-based prospective cohort study. Five eczema phenotypes (never, early transient, mid-transient, late transient, persistent) based on parental-reported physician-diagnosed eczema from age 6 months until 10 years were identified. At age 10 years, allergic sensitization was measured by skin prick tests, physician-diagnosed allergy and asthma by parent-reported questionnaires, and lung function by spirometry. Adjusted linear, logistic and multinomial regression models were applied. Results: Compared with never eczema, all eczema phenotypes were associated with increased risks of asthma (odds ratios (OR) range (95% confidence interval): 2.68 (1.58, 4.57) to 11.53 (6.65, 20.01)), food and inhalant allergic sensitization (1.72 (1.25, 2.36) to 12.64 (7.20, 22.18)), and physician-diagnosed inhalant allergy (1.92 (1.34, 2.74) to 11.91 (7.52, 18.86)). Strongest effect estimates were observed of early and persistent eczema with the risk of physician-diagnosed food allergy (OR 6.95 (3.76, 12.84) and 35.05 (18.33, 70.00), respectively) and combined asthma and physician-diagnosed allergy (7.11 (4.33, 11.67) and 29.03 (15.27, 55.22), respectively). Eczema phenotypes were not associated with lung function measures. Conclusion: Eczema phenotypes were differentially associated with risks of respiratory and allergic conditions in school-aged children. Children with early transient and persistent eczema might benefit from more intense follow-up for early identification and treatment of asthma and allergies
Gamma rays from dark matter annihilation in the Draco and observability at ARGO
The CACTUS experiment recently observed a gamma ray excess above 50 GeV from
the direction of the Draco dwarf spheroidal galaxy. Considering that Draco is
dark matter dominated the gamma rays may be generated through dark matter
annihilation in the Draco halo. In the framework of the minimal supersymmetric
extension of the standard model we explore the parameter space to account for
the gamma ray signals at CACTUS. We find that the neutralino mass is
constrained to be approximately in the range between 100 GeV ~ 400 GeV and a
sharp central cuspy of the dark halo profile in Draco is necessary to explain
the CACTUS results. We then discuss further constraints on the supersymmetric
parameter space by observations at the ground based ARGO detector. It is found
that the parameter space can be strongly constrained by ARGO if no excess from
Draco is observed above 100 GeV.Comment: 15 pages, 4 figure
The SmartTarget BIOPSY trial: A prospective, within-person randomised, blinded trial comparing the accuracy of visual-registration and MRI/ultrasound image-fusion targeted biopsies for prostate cancer risk stratification
Background: Multiparametric magnetic resonance imaging (mpMRI)-targeted prostate biopsies can improve detection of clinically significant prostate cancer and decrease the overdetection of insignificant cancers. Whether visual-registration targeting is sufficient or if augmentation with image-fusion software is needed is unknown.
Objective: To assess concordance between the two methods.
Design, Setting, and Participants: We conducted a blinded, within-person randomised, paired validating clinical trial. From 2014 to 2016, 141 men who had undergone a prior (positive or negative) transrectal ultrasound biopsy and had a discrete lesion on mpMRI (score 3 to 5) requiring targeted transperineal biopsy were enrolled at a UK academic hospital; 129 underwent both biopsy strategies and completed the study.
Intervention: The order of performing biopsies using visual-registration and a computer-assisted MRI/ultrasound image-fusion system (SmartTarget) on each patient was randomised. The equipment was reset between biopsy strategies to mitigate incorporation bias.
Outcome Measurements and Statistical Analysis: The proportion of clinically significant prostate cancer (primary outcome: Gleason pattern ≥3+4=7, maximum cancer core length ≥4 mm; secondary outcome: Gleason pattern ≥4+3=7, maximum cancer core length ≥6 mm) detected by each method was compared using McNemar's test of paired proportions.
Results and Limitations: The two strategies combined detected 93 clinically significant prostate cancers (72% of the cohort). Each strategy individually detected 80/93 (86%) of these cancers; each strategy detected 13 cases missed by the other. Three patients experienced adverse events related to biopsy (urinary retention, urinary tract infection, nausea and vomiting). No difference in urinary symptoms, erectile function, or quality of life between baseline and follow-up (median 10.5 weeks) was observed. The key limitation was lack of parallel-group randomisation and limit on number of targeted cores.
Conclusions: Visual-registration and image-fusion targeting strategies combined had the highest detection rate for clinically significant cancers. Targeted prostate biopsy should be performed using both strategies together.
Patient Summary: We compared two prostate cancer biopsy strategies: visual-registration and image-fusion. The combination of the two strategies found the most clinically important cancers and should be used together whenever targeted biopsy is being performed
Microstructural Characterization of a Prototype Titanium Alloy Structure Processed via Direct Laser Deposition (DLD)
Cosmological parameters from SDSS and WMAP
We measure cosmological parameters using the three-dimensional power spectrum
P(k) from over 200,000 galaxies in the Sloan Digital Sky Survey (SDSS) in
combination with WMAP and other data. Our results are consistent with a
``vanilla'' flat adiabatic Lambda-CDM model without tilt (n=1), running tilt,
tensor modes or massive neutrinos. Adding SDSS information more than halves the
WMAP-only error bars on some parameters, tightening 1 sigma constraints on the
Hubble parameter from h~0.74+0.18-0.07 to h~0.70+0.04-0.03, on the matter
density from Omega_m~0.25+/-0.10 to Omega_m~0.30+/-0.04 (1 sigma) and on
neutrino masses from <11 eV to <0.6 eV (95%). SDSS helps even more when
dropping prior assumptions about curvature, neutrinos, tensor modes and the
equation of state. Our results are in substantial agreement with the joint
analysis of WMAP and the 2dF Galaxy Redshift Survey, which is an impressive
consistency check with independent redshift survey data and analysis
techniques. In this paper, we place particular emphasis on clarifying the
physical origin of the constraints, i.e., what we do and do not know when using
different data sets and prior assumptions. For instance, dropping the
assumption that space is perfectly flat, the WMAP-only constraint on the
measured age of the Universe tightens from t0~16.3+2.3-1.8 Gyr to
t0~14.1+1.0-0.9 Gyr by adding SDSS and SN Ia data. Including tensors, running
tilt, neutrino mass and equation of state in the list of free parameters, many
constraints are still quite weak, but future cosmological measurements from
SDSS and other sources should allow these to be substantially tightened.Comment: Minor revisions to match accepted PRD version. SDSS data and ppt
figures available at http://www.hep.upenn.edu/~max/sdsspars.htm
A numerical investigation into the effects of parabolic curvature on the buckling strength and behaviour of stiffened plates under in-plane compression
Cosmological parameters from CMB and other data: a Monte-Carlo approach
We present a fast Markov Chain Monte-Carlo exploration of cosmological
parameter space. We perform a joint analysis of results from recent CMB
experiments and provide parameter constraints, including sigma_8, from the CMB
independent of other data. We next combine data from the CMB, HST Key Project,
2dF galaxy redshift survey, supernovae Ia and big-bang nucleosynthesis. The
Monte Carlo method allows the rapid investigation of a large number of
parameters, and we present results from 6 and 9 parameter analyses of flat
models, and an 11 parameter analysis of non-flat models. Our results include
constraints on the neutrino mass (m_nu < 0.3eV), equation of state of the dark
energy, and the tensor amplitude, as well as demonstrating the effect of
additional parameters on the base parameter constraints. In a series of
appendices we describe the many uses of importance sampling, including
computing results from new data and accuracy correction of results generated
from an approximate method. We also discuss the different ways of converting
parameter samples to parameter constraints, the effect of the prior, assess the
goodness of fit and consistency, and describe the use of analytic
marginalization over normalization parameters.Comment: Quintessence results now include perturbations. Changes to match
version accepted by PRD. MCMC code and data are available at
http://cosmologist.info/cosmomc/ along with a B&W printer-friendly version of
the pape
Evidence of Color Coherence Effects in W+jets Events from ppbar Collisions at sqrt(s) = 1.8 TeV
We report the results of a study of color coherence effects in ppbar
collisions based on data collected by the D0 detector during the 1994-1995 run
of the Fermilab Tevatron Collider, at a center of mass energy sqrt(s) = 1.8
TeV. Initial-to-final state color interference effects are studied by examining
particle distribution patterns in events with a W boson and at least one jet.
The data are compared to Monte Carlo simulations with different color coherence
implementations and to an analytic modified-leading-logarithm perturbative
calculation based on the local parton-hadron duality hypothesis.Comment: 13 pages, 6 figures. Submitted to Physics Letters
The State of the Dark Energy Equation of State
By combining data from seven cosmic microwave background experiments
(including the latest WMAP results) with large scale structure data, the Hubble
parameter measurement from the Hubble Space Telescope and luminosity
measurements of Type Ia supernovae we demonstrate the bounds on the dark energy
equation of state to be at the 95% confidence level.
Although our limit on is improved with respect to previous analyses,
cosmological data does not rule out the possibility that the equation of state
parameter of the dark energy is less than -1. We present a tracking
model that ensures at recent times and discuss the observational
consequences.Comment: 7 pages, 4 figures, added a referenc
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