6,906 research outputs found
The free energy in the Derrida--Retaux recursive model
We are interested in a simple max-type recursive model studied by Derrida and
Retaux (2014) in the context of a physics problem, and find a wide range for
the exponent in the free energy in the nearly supercritical regime
The nature of localization in graphene under quantum Hall conditions
Particle localization is an essential ingredient in quantum Hall physics
[1,2]. In conventional high mobility two-dimensional electron systems Coulomb
interactions were shown to compete with disorder and to play a central role in
particle localization [3]. Here we address the nature of localization in
graphene where the carrier mobility, quantifying the disorder, is two to four
orders of magnitude smaller [4,5,6,7,8,9,10]. We image the electronic density
of states and the localized state spectrum of a graphene flake in the quantum
Hall regime with a scanning single electron transistor [11]. Our microscopic
approach provides direct insight into the nature of localization. Surprisingly,
despite strong disorder, our findings indicate that localization in graphene is
not dominated by single particle physics, but rather by a competition between
the underlying disorder potential and the repulsive Coulomb interaction
responsible for screening.Comment: 18 pages, including 5 figure
Multiscale correlative tomography: an investigation of creep cavitation in 316 stainless steel
Creep cavitation in an ex-service nuclear steam header Type 316 stainless steel sample is investigated through a multiscale tomography workflow spanning eight orders of magnitude, combining X-ray computed tomography (CT), plasma focused ion beam (FIB) scanning electron microscope (SEM) imaging and scanning transmission electron microscope (STEM) tomography. Guided by microscale X-ray CT, nanoscale X-ray CT is used to investigate the size and morphology of cavities at a triple point of grain boundaries. In order to understand the factors affecting the extent of cavitation, the orientation and crystallographic misorientation of each boundary is characterised using electron backscatter diffraction (EBSD). Additionally, in order to better understand boundary phase growth, the chemistry of a single boundary and its associated secondary phase precipitates is probed through STEM energy dispersive X-ray (EDX) tomography. The difference in cavitation of the three grain boundaries investigated suggests that the orientation of grain boundaries with respect to the direction of principal stress is important in the promotion of cavity formation
Rapid generation of endogenously driven transcriptional reporters in cells through CRISPR/Cas9
CRISPR/Cas9 technologies have been employed for genome editing to achieve gene knockouts and knock-ins in somatic cells. Similarly, certain endogenous genes have been tagged with fluorescent proteins. Often, the detection of tagged proteins requires high expression and sophisticated tools such as confocal microscopy and flow cytometry. Therefore, a simple, sensitive and robust transcriptional reporter system driven by endogenous promoter for studies into transcriptional regulation is desirable. We report a CRISPR/Cas9-based methodology for rapidly integrating a firefly luciferase gene in somatic cells under the control of endogenous promoter, using the TGFβ-responsive gene PAI-1. Our strategy employed a polycistronic cassette containing a non-fused GFP protein to ensure the detection of transgene delivery and rapid isolation of positive clones. We demonstrate that firefly luciferase cDNA can be efficiently delivered downstream of the promoter of the TGFβ-responsive gene PAI-1. Using chemical and genetic regulators of TGFβ signalling, we show that it mimics the transcriptional regulation of endogenous PAI-1 expression. Our unique approach has the potential to expedite studies on transcription of any gene in the context of its native chromatin landscape in somatic cells, allowing for robust high-throughput chemical and genetic screens
Exploring the Intrabinary Shock from the Redback Millisecond Pulsar PSR J2129-0429
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Far-Ultraviolet Radiation from Elliptical Galaxies
Far-ultraviolet radiation is a ubiquitous, if unanticipated, phenomenon in
elliptical galaxies and early-type spiral bulges. It is the most variable
photometric feature associated with old stellar populations. Recent
observational and theoretical evidence shows that it is produced mainly by
low-mass, small-envelope, helium-burning stars in extreme horizontal branch and
subsequent phases of evolution. These are probably descendents of the dominant,
metal rich population of the galaxies. Their lifetime UV outputs are remarkably
sensitive to their physical properties and hence to the age and the helium and
metal abundances of their parents. UV spectra are therefore exceptionally
promising diagnostics of old stellar populations, although their calibration
requires a much improved understanding of giant branch mass loss, helium
enrichment, and atmospheric diffusion.Comment: 46 pages; includes LaTeX text file, 9 PS figures, 1 JPG figure, 2
style files. Full resolution figures and PS version available at
http://www.astro.virginia.edu/~rwo/araa99/. Article to appear in Annual
Reviews of Astronomy & Astrophysics, 199
Discovery Of An Ultracompact Gamma-ray Millisecond Pulsar Binary Candidate
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Discovery of X-ray Pulsation from the Geminga-like Pulsar PSR J 2021+4026
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A Detailed X-Ray Investigation of PSR J2021+4026 and the Îł-Cygni Supernova Remnant
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