8 research outputs found
DataAI-6G: A System Parameters Configurable Channel Dataset for AI-6G Research
With the acceleration of the commercialization of fifth generation (5G)
mobile communication technology and the research for 6G communication systems,
the communication system has the characteristics of high frequency, multi-band,
high speed movement of users and large antenna array. These bring many
difficulties to obtain accurate channel state information (CSI), which makes
the performance of traditional communication methods be greatly restricted.
Therefore, there has been a lot of interest in using artificial intelligence
(AI) instead of traditional methods to improve performance. A common and
accurate dataset is essential for the research of AI communication. However,
the common datasets nowadays still lack some important features, such as mobile
features, spatial non-stationary features etc. To address these issues, we give
a dataset for future 6G communication. In this dataset, we address these issues
with specific simulation methods and accompanying code processing
Asiatic acid improves high-fat-diet-induced osteoporosis in mice via regulating SIRT1/FOXO1 signaling and inhibiting oxidative stress
Asiatic acid can attenuate osteoporosis
through suppressing adipogenic differentiation and
osteoclastic differentiation. Oxidative stress enhances
osteoclastic differentiation but represses osteogenic
differentiation to promote osteoporosis. However, the
role and mechanism of asiatic acid in osteoporosis have
not been reported. Firstly, mice were fed with high-fatdiet (HFD) with or without asiatic acid for 16 weeks.
Data from an automatic biochemical analyzer showed
that HFD induced down-regulation of high-density
lipoprotein (HDL) and an increase of serum levels of
triglyceride (TG), total cholesterol (TC) and low-density
lipoprotein (LDL). However, asiatic acid administration
attenuated the decrease of HDL and increase of serum
TG, TC and LDL in osteoporotic mice. Secondly, HFD
induced high levels of malondialdehyde (MDA) and
reactive oxygen species (ROS), low levels of superoxide
dismutase (SOD) and glutathione peroxidase (GSH-Px)
in osteoporotic mice. However, the levels of MDA,
ROS, SOD and GSH-Px in osteoporotic mice were
reversed by asiatic acid administration. (this section is
unclear and requires revision) Asiatic acid
administration reduced expression of c-telopeptide of
type 1 collagen (CTX-1), enhanced alkaline phosphatase
(ALP) and procollagen type 1 N-terminal propeptide
(P1NP) in HFD-induced osteoporotic mice. (this section
is unclear and requires revision) Thirdly, asiatic acid
promoted calcium deposition in bone marrow cells and
osteogenic differentiation in osteoporotic mice, but
decreased ALP in bone marrow cells. Lastly, asiatic acid
enhanced SIRT1 and nuclear FOXO1 (Nu-FOXO1)
expression, while it reduced Acetyl FOXO1 (AcFOXO1) in osteoporotic mice. In conclusion, asiatic acid
might inhibit oxidative stress and promote osteogenic
differentiation through activating SIRT1/FOXO1 to
attenuate HFD-induced osteoporosis in mice
Aspirin, a potential GLUT1 inhibitor in a vascular endothelial cell line
Recent epidemiological and preclinical studies have revealed that aspirin possesses antitumor properties; one of the mechanisms results from inhibition of angiogenesis. However, the underlying mechanisms of such action remain to be elucidated, in particular, the effect of aspirin on glucose metabolism of vascular endothelial cells (ECs) has not yet been reported. Herein, we demonstrate that glucose transporter 1 (GLUT1), a main glucose transporter in ECs, can be down-regulated by aspirin. Exposure to 4-mM aspirin significantly decreased GLUT1 at the mRNA and protein level, resulting in impaired glucose uptake capacity in vascular ECs. In addition, we also showed that exposure to 4-mM aspirin led to an inhibition of intracellular ATP and lactate synthesis in vascular ECs, and a down-regulation of the phosphorylation level of NF-κB p65 was observed. Taken together, these findings indicate 4-mM aspirin inhibits glucose uptake and glucose metabolism of vascular ECs through down-regulating GLUT1 expression and suggest that GLUT1 has potential to be a target for aspirin in vascular ECs
A New Combined Stepwise-Based High-Order Decoupled Direct and Reduced-Form Method To Improve Uncertainty Analysis in PM<sub>2.5</sub> Simulations
The
traditional reduced-form model (RFM) based on the high-order
decoupled direct method (HDDM), is an efficient uncertainty analysis
approach for air quality models, but it has large biases in uncertainty
propagation due to the limitation of the HDDM in predicting nonlinear
responses to large perturbations of model inputs. To overcome the
limitation, a new stepwise-based RFM method that combines several
sets of local sensitive coefficients under different conditions is
proposed. Evaluations reveal that the new RFM improves the prediction
of nonlinear responses. The new method is applied to quantify uncertainties
in simulated PM<sub>2.5</sub> concentrations in the Pearl River Delta
(PRD) region of China as a case study. Results show that the average
uncertainty range of hourly PM<sub>2.5</sub> concentrations is −28%
to 57%, which can cover approximately 70% of the observed PM<sub>2.5</sub> concentrations, while the traditional RFM underestimates the upper
bound of the uncertainty range by 1–6%. Using a variance-based
method, the PM<sub>2.5</sub> boundary conditions and primary PM<sub>2.5</sub> emissions are found to be the two major uncertainty sources
in PM<sub>2.5</sub> simulations. The new RFM better quantifies the
uncertainty range in model simulations and can be applied to improve
applications that rely on uncertainty information