Undoing Apartheid, Becoming Children: Writing the Child in South African Literature

PhDThis thesis examines the trope of the child in South African literature from the early years of apartheid to the contemporary moment. The chapters focus on some of the most established and prolific authors in South African literary history and roughly follow a chronological sequence: autobiographies by the exiled Drum writers (Es’kia Mphahlele and Bloke Modisane) in the early 1960s; Nadine Gordimer’s writing during the apartheid era; confessional novels by Afrikaans-speaking authors (Mark Behr and Michiel Heyns) in the transitional decade; and J. M. Coetzee’s late and post apartheid works. I argue that, while writing from diverse historical and political positions in relation to South Africa’s literary culture, these authors are all in one way or another able to articulate their subjectivities—with their underlying ambiguities, contradictions, and negations—by imagining themselves as the child or/and through childhood. My analyses of the works under discussion attend to the subversive and transformative potential of, and the critical energies embedded in the trope of the child, by investigating narrative reconfigurations of temporality and space. Firstly, I will be looking at the ways in which the images, structures, and aesthetics making up the imaginings of the child disrupt a linear temporality and serve as critique of a teleological historiography of political emancipation and the liberation struggle. Secondly, I will pay attention to the spatial relations with which representations of the child are bound up: between the country and the city, black townships and white suburbs, the home and the street. By attending to specific transgressions and reorderings of these spatial relations, my reading also explores the ways in which spatial underpinnings and ideological boundaries of national identities are contested, negotiated, and restructured by forces of the transnational, the diasporic, and the global around the figure of the child.China Scholarship Council and Queen Mary University of London Queen Mary University of London Postgraduate Research Fund School of English and Drama Doctoral Allowanc

Exploring what synchronized physiological arousal can reveal about the social regulatory process in a collaborative argumentation activity

Combining physiological measures with observational data (e.g., video or self-reports) to further capture and understand the temporal and cyclical process of social regulation has become a trend in the field. Synchronized physiological arousal is a particularly meaningful situation in collaboration. However, little attention has been given to synchronized physiological arousal episodes and their relationship with the social regulatory process. In addition, only a few research utilized heart rate (HR) as a physiological measure in the current collaboration literature. More research is necessary to reveal the potential of HR to expand the diversity of physiological indicators in the field. Therefore, the current study aimed to explore what synchronized physiological arousal can further reveal about the social regulatory process. To achieve this goal, this study designed a collaborative argumentation (CA) activity for undergraduates (mean age 20.3). It developed an arousal-regulation analysis platform, which could automatically detect synchronized physiological arousal in HR and align them with coding challenges and social regulation based on the timeline. In total, 14 four-member groups were recruited. After analyzing both videos and HR data, several findings were obtained. First, only one-third of episodes were synchronized physiological arousal episodes, and the situations where four members were all in arousal states were rare during CA. Second, synchronized physiological arousal was more sensitive to socio-emotional aspects of collaboration as the shared physiological arousal more frequently co-occurred with socio-emotional challenges and socio-emotional regulation, while it happened the least under motivational challenges. Third, synchronized physiological arousal has also been found to be associated with the challenges being regulated. Finally, pedagogical implications were suggested

Mechanochemical Regulation of a Photochemical Reaction

We introduce the concept of mechanochemically gated photoswitching. Mechanical regulation of a photochemical reaction is exemplified using a newly designed mechanophore based on a cyclopentadiene–maleimide Diels–Alder adduct. Ultrasound-induced mechanical activation of the photochemically inert mechanophore in polymers generates a diarylethene photoswitch via a retro-[4 + 2] cycloaddition reaction that photoisomerizes between colorless and colored states upon exposure to UV and visible light. Control experiments demonstrate the thermal stability of the cyclopentadiene–maleimide adduct and confirm the mechanical origin of the “unlocked” photochromic reactivity. This technology holds promise for applications such as lithography and stress-sensing, enabling the mechanical history of polymeric materials to be recorded and read on-demand

Prompt-NER: Zero-shot Named Entity Recognition in Astronomy Literature via Large Language Models

This study delves into the application of Large Language Models (LLMs) for Named Entity Recognition (NER) tasks in the field of astronomy literature. To enhance the zero-shot recognition capabilities of LLMs for astronomical named entities, we propose a strategy called Prompt-NER. Prompt-NER includes five prompt elements: Task Descriptions, Entity Definitions, Task Emphasis, Task Examples, and Second Conversation. To assess the effectiveness of the Prompt-NER strategy, we utilize three representative LLMs (Claude-2, GPT-3.5, and LLaMA-2-70b) to identify telescope and celestial object named entities in astronomical literature. Our experiments are conducted based on two distinct datasets. The first dataset comprises 30 original PDF documents, which we split into paragraphs in sequential order, resulting in a second dataset consisting of 30 paragraph collections. Additionally, we incorporate 30 astronomical telegrams to diversify our experiments and assess the performance of LLMs based on Prompt-NER on concise, complete texts. Our experimental results indicate that the Prompt-NER strategy enables LLMs to effectively accomplish NER tasks in the field of astronomy, even without prior astronomical knowledge during training. We carefully analyze the experimental results, including the mechanism of different prompt elements and the influence of different features of long and short texts on their respective experimental results. This research provides experience for zero-shot NER tasks in astronomical literature and suggests future work in this area

MicroRNA-141 Represses HBV Replication by Targeting PPARA

MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression primarily at the post-transcriptional level and play critical roles in a variety of physiological and pathological processes. In this report, miR-141 was identified to repress HBV expression by screening a small miRNA expressing library and synthetic miR-141 mimics could also significantly suppress HBV expression and replication in HepG2 cells. Bioinformatic analysis and experiment assays indicate that peroxisome proliferator-activated receptor alpha (PPARA) was the target of hsa-miR-141 during this process. Furthermore, knockdown of PPARA by small interfering RNA (siRNA) inhibited HBV replication similar to levels observed for miR-141. Promoter functional analysis indicated that repression of HBV replication by miR-141 mimics or siRNA was mediated by interfering with the HBV promoter functions, consistent with previous studies demonstrating that PPARA regulated HBV gene expression through interactions with HBV promoter regulatory elements. Our results suggest that miR-141 suppressed HBV replication by reducing HBV promoter activities by down-regulating PPARA. This study provides new insights into the molecular mechanisms associated with HBV-host interactions. Furthermore, this information may facilitate the development of novel anti-HBV therapeutic strategies

Mechanically Triggered Small Molecule Release from a Masked Furfuryl Carbonate

Stimuli-responsive polymers that release small molecules under mechanical stress are appealing targets for applications ranging from drug delivery to sensing. Here, we describe a modular mechanophore design platform for molecular release via a mechanically triggered cascade reaction. Mechanochemical activation of a furan–maleimide Diels–Alder adduct reveals a latent furfuryl carbonate that subsequently decomposes under mild conditions to release a covalently bound cargo molecule. The computationally guided design of a reactive secondary furfuryl carbonate enables the decomposition and release to proceed quickly at room temperature after unmasking via mechanical force. This general strategy is demonstrated using ultrasound-induced mechanical activation to release a fluorogenic coumarin payload from a polymer incorporating a chain-centered mechanophore

Mechanochemical Regulation of a Photochemical Reaction

We introduce the concept of mechanochemically gated photoswitching. Mechanical regulation of a photochemical reaction is exemplified using a newly designed mechanophore based on a cyclopentadiene–maleimide Diels–Alder adduct. Ultrasound-induced mechanical activation of the photochemically inert mechanophore in polymers generates a diarylethene photoswitch via a retro-[4 + 2] cycloaddition reaction that photoisomerizes between colorless and colored states upon exposure to UV and visible light. Control experiments demonstrate the thermal stability of the cyclopentadiene–maleimide adduct and confirm the mechanical origin of the “unlocked” photochromic reactivity. This technology holds promise for applications such as lithography and stress-sensing, enabling the mechanical history of polymeric materials to be recorded and read on-demand

Mechanochemically Gated Photoswitching: Expanding the Scope of Polymer Mechanochromism

Mechanophores are molecules that undergo productive, covalent chemical transformations in response to mechanical force. Over the last decade, a variety of mechanochromic mechanophores have been developed that enable the direct visualization of stress in polymers and polymeric materials through changes in color and chemiluminescence. The recent introduction of mechanochemically gated photoswitching extends the repertoire of polymer mechanochromism by decoupling the mechanical activation from the visible response, enabling the mechanical history of polymers to be recorded and read on-demand using light. Here, we discuss advances in mechanochromic mechanophores and present our design of a cyclopentadiene–maleimide Diels–Alder adduct that undergoes a force-induced retro-[4+2] cycloaddition reaction to reveal a latent diarylethene photoswitch. Following mechanical activation, UV light converts the colorless diarylethene molecule into the colored isomer via a 6π-electrocyclic ring-closing reaction. Mechanically gated photoswitching expands on the fruitful developments in mechanochromic polymers and provides a promising platform for further innovation in materials applications including stress sensing, patterning, and information storage