DesignTracking: Track and Replay BIM-based Design Process

Among different phases of the life cycle of a building or facility, design is of the utmost importance to ensure safety, efficiency and sustainability of the building or facility. How to control and improve design quality and efficiency has been explored for years, and more studies emerged with the popularization of Building Information Modelling (BIM). However, most of them focused on the extraction of design behaviors, while paying less attention to how a design is formed. Therefore, this study proposes an approach to tracking and replaying the BIM-based design process by integrating data logging and 4D visualization techniques. First of all, potential design behaviors and procedures are analyzed and extracted by observing how a designer designs a BIM model. Meanwhile, the required data for logging design process is defined and a relevant method to collect these data is developed based on the APIs of BIM software. Then, strategies on how to visualize different design procedures are designed and implemented via 4D visualization. Finally, a prototype system is developed based on Autodesk Revit and validated through a case study. Result shows that the proposed approach enables intuitively and interactively review of the design process, and makes it easier to understand design behaviors and even identify potential pitfalls, thus improving the design efficiency and quality

Synergistic Effect of Trehalose and Saccharose Pretreatment on Maintenance of Lyophilized Human Red Blood Cell Quality

Purpose: To investigate the synergistic effect of trehalose and saccharose pretreatment on maintenance of lyophilized human red blood cell (RBC) quality.Methods: RBCs were pre-treated with trehalose and saccharose, and then lyophilized and re-hydrated. Prior to lyophilization and after re hydration, RBC parameters, RBC counts, total hemoglobin concentration, mean corpuscular hemoglobin (MCH), mean corpuscular volume (MCV), comprehensive deformation index, hemolysis ratio and phosphatidylserine (PS) expression, were determined using a hematology analyzer, an RBC deformation instrument, a spectrophotometer and a flow cytometer, respectively. Superoxide dismutase (SOD), glucose-6-phosphate dehydrogenase (G-6-PD), and adenosine triphosphatase (ATPase) activities were determined using kits for SOD, ATPase, and G-6- PD assay, respectively.Results: After lyophilization-rehydration, RBC counts and total hemoglobin recovery rates, deformability, and RBC SOD, ATPase, and G-6-PD activities were significantly decreased by 47.24 – 74.65 % (p < 0.01), compared with the normal group. RBC osmotic fragility and PS expression on the outer surface of the RBC membrane were significantly increased by 168.53 and 629.30 % (p < 0.01), respectively, compared with the normal group. RBC MCH and MCV values were not significantly affected by lyophilization rehydration (p > 0.05). Trehalose and saccharose pretreatment significantly reversed the effects of lyophilization-rehydration on these RBC parameters by approximately 13.16 – 211.11 % (p < 0.01), compared with the control group. The combined effects were synergistic.Conclusion: Trehalose and saccharose pretreatment synergistically enhances maintenance of lyophilized RBC quality.Keywords: Trehalose, Saccharose, Lyophilization, Red blood cell, Hematological parameter

catena-Poly[[diaqua­nickel(II)]-μ-7-oxabicyclo­[2.2.1]heptane-2,3-di­carboxyl­ato]

In the crystal structure of the title compound, [Ni(C8H8O5)(H2O)2]n, the NiII cation is in a Jahn–Teller-distorted octahedral coordination environment binding to two O atoms from water molecules, the bridging O atom of the bicycloheptane unit, two carboxylate O atoms from different carboxylate groups and one carboxylate O atom from a symmetry-related bridging ligand. The crystal structure is made up from layers propagating parallel to the bc plane

Hypersonic wave wall flow based on gas kinetic method

The transition of hypersonic boundary layer can lead to a several-fold increase in surface heat flux and skin friction for the aircraft, significantly impacting its flight performance. The corrugated wall, as a passive control method for boundary layer flow, also serves as a type of wall microstructure, making its study on the local rarefaction effect of considerable engineering significance. In this study, we employed the conservative discrete unified gas dynamic scheme and utilized a domain-wide numerical simulation method. Initially, we simulated the hypersonic flat plate flow with different depths of corrugated walls under the conditions of incoming flow Mach number of 6 and Reynolds number of ${{10}^{7}}$. Subsequently, we investigated the effects of corrugated walls, including flat plate corrugated walls and wedge corrugated walls, under varying Reynolds numbers for an incoming flow Mach number of 6, and discussed the impact of local rarefaction effect of corrugated walls under different Reynolds numbers. By using the local Knudsen number as the criterion, we found that under these conditions, the occurrence of local rarefaction effect near the corrugated wall due to consecutive failures does not take place when the incoming Reynolds number reaches ${{10}^{7}}$ or ${{10}^{6}}$. However, when the incoming Reynolds number drops to ${{10}^{5}}$, the local rarefaction effect near the corrugated wall becomes evident, with the appearance of non-equilibrium effects in translational and rotational temperatures of molecules. This phenomenon becomes more pronounced as the Reynolds number decreases further