Compression Molding and Novel Sintering Treatments for Alnico Type-8 Permanent Magnets in Near-Final Shape with Preferred Orientation

Economic uncertainty in the rare earth (RE) permanent magnet marketplace, as well as in an expanding electric drive vehicle market that favors permanent magnet alternating current synchronous drive motors, motivated renewed research in RE-free permanent magnets like “alnico,” an Al-Ni-Co-Fe alloy. Thus, high-pressure, gas-atomized isotropic type-8H pre-alloyed alnico powder was compression molded with a clean burn-out binder to near-final shape and sintered to density \u3e99% of cast alnico 8 (full density of 7.3 g/cm3). To produce aligned sintered alnico magnets for improved energy product and magnetic remanence, uniaxial stress was attempted to promote controlled grain growth, avoiding directional solidification that provides alignment in alnico 9. Successful development of solid-state powder processing may enable anisotropically aligned alnico magnets with enhanced energy density to be mass-produced

Enhanced B7-H4 expression in gliomas with low PD-L1 expression identifies super-cold tumors.

BACKGROUND: Characterizing expression profiles of different immune checkpoint molecules are promising for personalized checkpoint inhibitory immunotherapy. Gliomas have been shown as potential targets for immune checkpoint inhibitors recently. Our study was performed to determine coexpression levels of two major B7 immune regulatory molecules programmed death ligand 1 (PD-L1) and B7-H4, both of which have been demonstrated to inhibit antitumor host immunity in gliomas. METHODS: We assessed tumor tissues from stage II-IV primary gliomas (n=505) by immunohistochemistry (IHC) for protein levels of both PD-L1 and B7-H4. Gene coexpression analysis assessing clusters based on extent of PD-L1/B7-H4 classifier genes expression were investigated in two transcriptome datasets (The Cancer Genome Atlas and Chinese Glioma Genome Atlas). In addition, levels of immune cell infiltrates were estimated with IHC and RNA-seq data for assessing the tumor immune microenvironment of PD-L1/B7-H4 subgroups. RESULTS: High expression of PD-L1 and B7-H4 in gliomas was 23% and 20%, respectively, whereas coexpression of two proteins at high levels was limited to 2% of the cases. Comparable results were seen in RNA-seq datasets where PD-L1 mRNA expression levels negatively correlated with that of B7-H4. Gene coexpression modules clustered within each grade of gliomas demonstrated lack of double-high modules (cluster with high expression of both PD-L1 and B7-H4 classifier genes). B7-H4 mRNA expression levels showed negative correlation with extent of immune cell infiltration and High-B7-H4 module gliomas (high B7-H4 but low PD-L1 classifier genes expression) had less tumor-infiltrating lymphocytes (TILs) and tumor-associated macrophages (TAMs). IHC assessment also showed few TILs and TAMs in High-B7-H4 subgroup gliomas. CONCLUSIONS: The majority of gliomas express PD-L1 or B7-H4, however, coexpression of both at high levels is minimal. The high-B7-H4 patients could be considered as \u27super-cold\u27 gliomas with significantly deficient in TILs, suggesting that B7-H4 might inhibit T-cell trafficking into the central nervous system. This study demonstrated that PD-L1 and B7-H4 may serve as mutually compensatory immune checkpoint molecules in gliomas for immune targeted or active-specific immunotherapy. The distinct B7-H4 pathways modulating T-cell function and immune evasion in glioma patients deserved to be further explored in the future during immunotherapy

CD133 (Prominin) Negative Human Neural Stem Cells Are Clonogenic and Tripotent

CD133 (Prominin) is widely used as a marker for the identification and isolation of neural precursor cells from normal brain or tumor tissue. However, the assumption that CD133 is expressed constitutively in neural precursor cells has not been examined

Numerical simulation of size effect of defective rock under compression condition

Abstract The existence of various types of damage, small cracks, some large voids and the size of the sample in the rock will make the experimental results show great discreteness. In this paper, based on the results of laboratory experiments, a numerical model of large flawed rock samples is established by using particle flow software PFC2D, and the mechanical response of rocks with different length-diameter ratios and different flaw positions in uniaxial compression experiments is discussed. The results show that the specimen size has a significant effect on the crack characteristics, mechanical characteristics and energy characteristics of rock mass. From the perspective of energy and crack characteristics, the total number of cracks after the failure of the defective rock sample is slightly lower than that of the intact rock sample, resulting in a slightly lower peak strain energy during the rock failure process. From the mechanical properties of rock samples, the Poisson’s ratio of intact rock samples is slightly smaller than that of defective rock samples. The strength of the defective sample is weakened relative to the complete rock sample, and the relationship formula between the weakening range and the aspect ratio is obtained through analysis. Moreover, different defect locations lead to different crack processes and crack modes, resulting in different uniaxial compressive strength

Tin (IV) Chloride-Promoted One-Pot Synthesis of Novel Tacrine Analogues

A facile synthesis of potential acetylcholinesterase (AChE) inhibitors, the tacrine analogues 3a-p, has been accomplished by direct cyclocondensation of 1-aryl-4-cyano-5-aminopyrazole with β-ketoesters using tin(IV) chloride as catalyst. The structures of all the compounds have been confirmed by IR, 1H- and 13C-NMR

Compression Molding and Novel Sintering Treatments for Alnico Type-8 Permanent Magnets in Near-Final Shape with Preferred Orientation

Economic uncertainty in the rare earth (RE) permanent magnet marketplace, as well as in an expanding electric drive vehicle market that favors permanent magnet alternating current synchronous drive motors, motivated renewed research in RE-free permanent magnets like “alnico,” an Al-Ni-Co-Fe alloy. Thus, high-pressure, gas-atomized isotropic type-8H pre-alloyed alnico powder was compression molded with a clean burn-out binder to near-final shape and sintered to density >99% of cast alnico 8 (full density of 7.3 g/cm3). To produce aligned sintered alnico magnets for improved energy product and magnetic remanence, uniaxial stress was attempted to promote controlled grain growth, avoiding directional solidification that provides alignment in alnico 9. Successful development of solid-state powder processing may enable anisotropically aligned alnico magnets with enhanced energy density to be mass-produced.</p

Study on Blasting Characteristics of Soft-Hard Rock Strata Based on Energy Fields and Particle Expansion Loading Algorithm

Complex geological conditions often make the blasting effect difficult to control. In order to explore the influence of soft-hard rock strata on rock blasting characteristics, based on PFC2D software, combined with particle expansion loading algorithm, the numerical simulation blasting experiments are carried out. Firstly, the rationality of blasting method is verified by single-hole sandstone blasting experiment. Then, the soft-hard composite strata are established, and the single-hole blasting experiments of composite strata, with different distribution thickness of soft rock stratum and hard rock stratum, are carried out. The experimental results are analyzed from three perspectives: crack network state, internal stress of rock mass, and energy field. Results show that (i) the distance between the interface of soft-hard rock and the blasthole seriously affects the blasting effect. The law of crack number varying with the distance is obtained through further analysis. (ii) When detonated in the hard rock, if the structural plane is about 2 times the radius of crushing area from blasthole, the rock mass will be in a relatively high stress state due to the reflection and superposition of stress waves. (iii) When detonated in the hard rock, if the structural plane is about 2 times the radius of crushing area from blasthole, compared with pure hard rock case, the peak kinetic energy and peak friction energy are increased by about 15 times and 2.6 times, respectively, and the peak strain energy is attenuated by 18%

Diurnal haze variations over the North China plain using measurements from Himawari-8/AHI

International audienceThe diurnal variations of haze properties are essential in understanding the haze pollution formation and its environmental impact. Ground-based measurements can provide this information with high temporal resolution, but the haze measurements are not spatially continuous. The Advanced Himawari Imager (AHI) sensor onboard the next-generation geostationary satellite Himawari-8 can provide haze properties with high spatial and temporal resolution. In this study, the diurnal variations of haze frequency, haze properties [aerosol optical depth (AOD), Angstrom exponent (AE) and fine-particle ratio (RF)] and cloud cover are jointly analyzed over the North China Plain (NCP) for summer and winter seasons during 2015-2017. Both the haze and cloud scheme and the haze properties are well validated. The results reveal that the haze frequency in winter (33.51%) is much higher than that in summer (6.34%), and the diurnal variations of AOD values in winter (0.2-0.9) are stronger than those in summer (0.5-0.9). The diurnal maximum haze frequency values in summer (16:00 p.m.) occur 3 h later than the most severe pollution (13:00 p.m.), with AOD values of 0.7-0.9, AE values of 1.1-1.2 and RF values of 0.5-0.6. In winter, the haze frequency increases from 9:00 to 15:00. However, no typical diurnal variations of AOD, AE and RF are shown. It is also found that haze frequency exhibits opposite diurnal variations compared with those of clouds