679 research outputs found

    Neuroprotective Effects of San-Huang-Xie-Xin-Tang in the MPP+/MPTP Models of Parkinson's Disease In Vitro and In Vivo

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    San-Huang-Xie-Xin-Tang (SHXT), composed of Coptidis rhizoma, Scutellariae radix, and Rhei rhizoma, is a traditional Chinese medicine used for complementary and alternative therapy of cardiovascular and neurodegenerative diseases via its anti-inflammatory and antioxidative effects. The aim of this study is to investigate the protective effects of SHXT in the 1–methyl–4–phenylpyridinium (MPP+)/1–methyl–4–phenyl–1,2,3,6–tetrahydropyridine (MPTP) models of Parkinson's disease. Rat primary mesencephalic neurons and mouse Parkinson disease model were used in this study. Oxidative stress was induced by MPP+ in vitro and MPTP in vivo. In MPP+-treated mesencephalic neuron cultures, SHXT significantly increased the numbers of TH-positive neurons. SHXT reduced apoptotic signals (cytochrome and caspase) and apoptotic death. MPP+-induced gp91phox activation and ROS production were attenuated by SHXT. In addition, SHXT increased the levels of GSH and SOD in MPP+-treated neurons. In MPTP animal model, SHXT markedly increased TH-positive neurons in the substantia nigra pars compacta (SNpc) and improved motor activity of mice. In conclusion, the present results reveal the evidence that SHXT possesses beneficial protection against MPTP-induced neurotoxicity in this model of Parkinson's disease via its antioxidative and antiapoptotic effects. SHXT might be a potentially alternative and complementary medicine for neuroprotection

    Twin Pregnancy with Gastroschisis in Both Twins

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    SUMMARYObjectiveGastroschisis is a congenital malformation characterized by an abdominal wall defect located laterally to a normal umbilicus. The cause of gastroschisis is unknown, but most authors consider it exogenous. We describe the case of a woman with a twin pregnancy in which both twins had gastroschisis.Case ReportA 17-year-old primiparous female was referred to our institution because of a twin pregnancy, with one twin diagnosed with gastroschisis at 34 weeks of gestation. Unfortunately, gastroschisis was noted in both twins, but no other anomalies were observed under level II sonographic evaluation. The twins were delivered by cesarean section at 36+weeks of gestation because of preterm labor and breech presentation of one fetus. Both twins presented with a 3-cm abdominal wall defect located to the right side of the umbilicus and a large portion of the bowel protruding that was not covered by membrane. Histopathology of the placenta revealed that the twins were diamniotic monochorionic. Chromosomal analysis of cord blood showed normal karyotype (46, XX) in both newborns.ConclusionThe cause of gastroschisis is unknown, although possible exogenous causes have been studied. The diagnosis of gastroschisis in twin pregnancy is always in late gestation. Therefore, maternal serum alpha feto-protein screening and a detailed prenatal ultrasound evaluation are recommended in multifetal pregnancies

    PGT-Net: Progressive Guided Multi-task Neural Network for Small-area Wet Fingerprint Denoising and Recognition

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    Fingerprint recognition on mobile devices is an important method for identity verification. However, real fingerprints usually contain sweat and moisture which leads to poor recognition performance. In addition, for rolling out slimmer and thinner phones, technology companies reduce the size of recognition sensors by embedding them with the power button. Therefore, the limited size of fingerprint data also increases the difficulty of recognition. Denoising the small-area wet fingerprint images to clean ones becomes crucial to improve recognition performance. In this paper, we propose an end-to-end trainable progressive guided multi-task neural network (PGT-Net). The PGT-Net includes a shared stage and specific multi-task stages, enabling the network to train binary and non-binary fingerprints sequentially. The binary information is regarded as guidance for output enhancement which is enriched with the ridge and valley details. Moreover, a novel residual scaling mechanism is introduced to stabilize the training process. Experiment results on the FW9395 and FT-lightnoised dataset provided by FocalTech shows that PGT-Net has promising performance on the wet-fingerprint denoising and significantly improves the fingerprint recognition rate (FRR). On the FT-lightnoised dataset, the FRR of fingerprint recognition can be declined from 17.75% to 4.47%. On the FW9395 dataset, the FRR of fingerprint recognition can be declined from 9.45% to 1.09%

    Intrinsic Bulk Quantum Oscillations in a Bulk Unconventional Insulator SmB6.

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    The finding of bulk quantum oscillations in the Kondo insulator SmB6 proved a considerable surprise. Subsequent measurements of bulk quantum oscillations in other correlated insulators including YbB12 lent support to our discovery of a class of bulk unconventional insulators that host bulk quantum oscillations. Here we perform a series of experiments to examine evidence for the intrinsic character of bulk quantum oscillations in floating zone-grown single crystals of SmB6 that have been the subject of our quantum oscillation studies. We present results of thermodynamic, transport, and composition analysis experiments on pristine floating zone-grown single crystals of SmB6 and compare quantum oscillations with metallic LaB6 and elemental aluminum. These results establish the intrinsic origin of quantum oscillations from the insulating bulk of floating zone-grown SmB6. The similarity of the Fermi surface in insulating SmB6 with the conduction-electron Fermi surface in metallic hexaborides is at the heart of a theoretical mystery
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