LA TRADUCCIÓN DE LAS ESTRATEGIAS DE CORTESÍA EN LA CORRESPONDENCI A COMERCIAL EN LENGUA CHINA Y LENGUA ESPAÑOLA

Nowadays, globalization has increased the communication between East and West.  Translation is clearly playing a fundamental role in this wave of globalization which is growing at a breakneck pace, and contacts between Spanish speaking and Chinese speaking countries are increasing in frequency. In the field of international trade,  Chinese-Spanish  commercial  correspondence  genres  are  amongst  the  most translated. A translator’s ignorance of the characteristics of these genres may lead to misunderstandings and even to breakdowns in communication. The aim of this research is to study and compare the politeness strategies used in Chinese and Span- ish commercial correspondence and to use the results to provide guidelines for the translation of these genres from Chinese into Spanish and from Spanish into Chinese.La globalización ha aumentado hoy en día la comunicación entre Occidente y Oriente y la traducción desempeña un papel fundamental en esta ola de globalización que evoluciona de manera vertiginosa y acelerada. Cada vez son más estrechos los contactos entre el mundo de habla hispánica y el de habla china. En el ámbito del comercio exterior, uno de los géneros textuales más traducidos proviene de la correspondencia  comercial  en  chino  y  español.  El  desconocimiento  por  parte  del traductor de las características de los géneros textuales puede provocar malentendidos e, incluso, impedir la comunicación. Este trabajo tiene como objetivo estudiar y comparar las estrategias de cortesía usadas en la correspondencia comercial en chino y  en español y ofrecer pautas a los traductores para la traducción de textos de este género del chino al español o viceversa

Sequence features involved in the mechanism of 3' splice junction wobbling

Background Alternative splicing is an important mechanism mediating the diversified functions of genes in multicellular organisms, and such event occurs in around 40-60% of human genes. Recently, a new splice-junction wobbling mechanism was proposed that subtle modifications exist in mRNA maturation by alternatively choosing at 5'- GTNGT and 3'- NAGNAG, which created single amino acid insertion and deletion isoforms. Results By browsing the Alternative Splicing Database information, we observed that most 3' alternative splice site choices occur within six nucleotides of the dominant splice site and the incidence significantly decreases further away from the dominant acceptor site. Although a lower frequency of alternative splicing occurs within the intronic region (alternative splicing at the proximal AG) than in the exonic region (alternative splicing at the distal AG), alternative AG sites located within the intronic region show stronger potential as the acceptor. These observations revealed that the choice of 3' splice sites during 3' splicing junction wobbling could depend on the distance between the duplicated AG and the branch point site (BPS). Further mutagenesis experiments demonstrated that the distance of AG-to-AG and BPS-to-AG can greatly influence 3' splice site selection. Knocking down a known alternative splicing regulator, hSlu7, failed to affect wobble splicing choices. Conclusion Our results implied that nucleotide distance between proximal and distal AG sites has an important regulatory function. In this study, we showed that occurrence of 3' wobble splicing occurs in a distance-dependent manner and that most of this wobble splicing is probably caused by steric hindrance from a factor bound at the neighboring tandem motif sequence

Plasma levels in sepsis patients of annexin A1, lipoxin A4, macrophage inflammatory protein-3a, and neutrophil gelatinase-associated lipocalin

AbstractBackgroundThe relationship between the various cytokine responses that occur during sepsis remains controversial. Emerging evidence indicates that the proinflammatory and anti-inflammatory responses are regulated simultaneously from the beginning of sepsis. However, the roles of the novel anti-inflammatory mediators annexin (Anx)A1 and lipoxin (LX)A4 and the proinflammatory cytokines neutrophil gelatinase-associated lipocalin (NGAL) and macrophage inflammatory protein (MIP)-3a have been studied.MethodsIn this study, the plasma levels of AnxA1, LXA4, NGAL, MIP-3a, interleukin (IL)-8 and IL-6 in patients with sepsis were determined on admission to the intensive care unit. The patients were classified into survivors and non-survivors based on their outcome on day 28.ResultsAnxA1 and LXA4 levels were decreased in sepsis patients compared with control patients, whereas the levels of the proinflammatory cytokines MIP-3a, NGAL, IL-8, and IL-6 were elevated. Furthermore, a significantly higher level of MIP-3a was detected in nonsurviving patients compared with surviving patients (p < 0.05), whereas there were no significant differences between these two groups for the levels of the other mediators. Correlation analysis demonstrated that only NGAL level was closely correlated with the level of IL-6. Univariate analysis indicated that the levels of MIP-3a and IL-8 were independent factors associated with patient survival, but this was not confirmed by the multivariate analysis.ConclusionAnxA1 and LXA4 plasma levels were found to be decreased in sepsis patients, whereas the levels of MIP-3a and NGAL were found to be elevated. This warrants further study in order to determine the clinical implications of these changes

An Extended Analytic Solution of Combined Refraction and Diffraction of Long Waves Propagating over Circular Island

An analytic solution of long waves scattering by a cylindrical island mounted on a permeable circular shoal was obtained by solving the linear long wave equation (LWE). The solution is in terms of the Bessel function expressed by complex variables. The present solution is suitable for arbitrary bottom configurations described by a power function with two independent parameters. For the case of the paraboloidal shoal, there exists a singular point (α=2) which can be removed using Frobenius series, where α is a real constant. The present solution is reduced to Yu and Zhang’s (2003) solution for impermeable circular shoal. The numerical results show some special features of the combined effect of wave refraction and diffraction caused by a porous circular island. The effect of key parameters of the island dimension, the shoal slope, and permeability on wave scattering was discussed based on the analytic solution

Maintaining the structural integrity of thebamboo mosaic virus 3′ untranslated region isnecessary for retaining the catalytic constant forminus-strand RNA synthesis

Background: Bamboo mosaic virus (BaMV) and the Potato virus X (PVX) are members of the genus Potexvirus andhave a single-stranded positive-sense RNA genome. The 3′-untranslated region (UTR) of the BaMV RNA genomewas mapped structurally into ABC (a cloverleaf-like), D (a stem-loop), and E (pseudoknot) domains. The BaMVreplicase complex that was isolated from the infected plants was able to recognize the 3′ UTR of PVX RNA toinitiate minus-strand RNA synthesis in vitro.Results: To investigate whether the 3′ UTR of PVX RNA is also compatible with BaMV replicase in vivo, weconstructed chimera mutants using a BaMV backbone containing the PVX 3′ UTR, which was inserted in or used toreplace the various domains in the 3′ UTR of BaMV. None of the mutants, except for the mutant with the PVX3′ UTR inserted upstream of the BaMV 3′ UTR, exhibited a detectable accumulation of viral RNA in Nicotianabenthamiana plants. The in vitro BaMV RdRp replication assay demonstrated that the RNA products were generatedby the short RNA transcripts, which were derived from the chimera mutants to various extents. Furthermore, theVmax/KM of the BaMV 3′ UTR (rABCDE) was approximately three fold higher than rABCP, rP, and rDE in minus-strandRNA synthesis. These mutants failed to accumulate viral products in protoplasts and plants, but were adequatelyreplicated in vitro.Conclusions: Among the various studied BaMV/PVX chimera mutants, the BaMV-S/PABCDE that containednon-interrupted BaMV 3′ UTR was the only mutant that exhibited a wild-type level of viral product accumulation inprotoplasts and plants. These results indicate that the continuity of the domains in the 3′ UTR of BaMV RNA wasnot interrupted and the domains were not replaced with the 3′ UTR of PVX RNA in vivo

Attenuated Cardiac Mitochondrial-Dependent Apoptotic Effects by Li-Fu Formula in Hamsters Fed with a Hypercholesterol Diet

Apoptosis involves in the pathogenesis of various cardiac abnormalities. This study intends to evaluate the effects of Li-Fu formula on cardiac apoptosis induced by hyper-cholesterol diet. Twenty-four male Golden Syrian hamsters were randomly divided into Control, Cholesterol and Li-Fu formula groups. Histopathological analysis, western blotting and terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assays were performed to measure the effects of Li-Fu formula on left ventricle. Significantly reduced TUNEL-positive cells and mitochondria- dependent apoptosis were observed in the left ventricle of hamsters from Li-Fu formula group compared to the Cholesterol group. Additionally, induced cardiac insulin like growth factor I receptor (IGFIR)-dependent survival pathway was detected in the Li-Fu formula group compared to the Cholesterol group. Besides, minor fibrosis, increased collagen deposition, and myofibril disarray was detected in the Cholesterol group, whereas the reductions of collagen deposition and myofibril disarray were observed in the Li-Fu formula group. This study demonstrated that Li-Fu formula not only reduced the mitochondria-dependent apoptosis and fibrosis, but also enhanced the IGF-I survival pathway in the left ventricle from high cholesterol-fed hamsters. We suggest the protective effects of Li-Fu formula on cardiac apoptosis and therapeutic potentials against cardiovascular disease

On Step Approximation for Roseau's Analytical Solution of Water Waves

An indirect eigenfunction marching method (IEMM) is developed to provide step approximations for water wave problems. The bottom profile is in terms of successive flat shelves separated by abrupt steps. The marching conditions are represented by the horizontal velocities at the steps in the solution procedure. The approximated wave field can be obtained by solving a system of linear equations with unknown coefficients which represents the horizontal velocities under a proper basis. It is also demonstrated that this solution method can be exactly reduced to the transfer-matrix method (TM method) for a specific setting. The combined scattering effects of a series of steps can be described by a single two-by-two transfer matrix for connecting the far-field behaviors of both sides for this method. The solutions obtained by the IEMM are basically exact for water wave problems considering step-like bottoms. Numerical simulations were performed to validate the present and commonly used methods. Furthermore, it also shows that the solutions obtained by the IEMM converge very well to Roseau's analytical solutions for both mild and steep curved bottom profiles. The present method improves the converges of the TM method for solving water wave scattering over steep bathymetry