NERVE CONDUCTION VELOCITY INVESTIGATION IN ATHLETES WITH TRAINED LOWER EXTRAMITY FOR WELL·CONTROLLlNG MOVEMENT

Reaction, coordination and speed ability are essential for success in a variety of sports. Nerve conduction velocity (NCV) is related to all of these abilities. Previous studies had investigated power and endurance type athletes, but there is less research in athletes who are skilled in coordinated lower extremity movements requiring more neural adaptation for nerve conduction velocity after specific exercise training. The purpose of this study is to investigate nerve conduction velocity of soccer, sanshou players and untrained subjects. Results show that NCV was significantly different among the 3 groups (p < .05) for the femoral and tibal nerves. For both femoral and tibial nerve.§, results showed that the soccer players had significantly faster NCV than the other groups (p < .05). According to the results, faster NCV adaptation from long term training in soccer players may be relate to their movement requirement of changing their movement direction quickly and skillfully

Terminalia catappa

High mortality and morbidity rates for hepatocellular carcinoma (HCC) in Taiwan primarily result from uncontrolled tumor metastasis. Previous studies have identified that Terminalia catappa leaf extracts (TCE) exert hepatoprotective, antioxidative, antiinflammatory, anticancer, and antimetastatic activities. However, the effects of TCE on HCC and the underlying molecular mechanisms of its activities have yet to be fully elucidated. The present study's findings demonstrate that TCE concentration dependently inhibits human HCC migration/invasion. Zymographic and western blot analyses revealed that TCE inhibited the activities and expression of matrix metalloproteinase-9 (MMP-9). Assessment of mRNA levels, using reverse transcriptase polymerase chain reaction (PCR) and real-time PCR, and promoter assays confirmed the inhibitory effects of TCE on MMP-9 expression in HCC cells. The inhibitory effects of TCE on MMP-9 proceeded by upregulating tissue inhibitor of metalloproteinase-1 (TIMP-1), as well as suppressing nuclear translocation and DNA binding activity of nuclear factor-kappa B (NF-κB) and activating protein-1 (AP-1) on the MMP-9 promoter in Huh7 cells. In conclusion, TCE inhibits MMP-9 expression and HCC cell metastasis and, thus, has potential use as a chemopreventive agent. Its inhibitory effects are associated with downregulation of the binding activities of the transcription factors NF-κB and AP-1

POOR FORCE CONTROL PERFORMANCE AND UNVARIED EMG PATTERN AFTER AGONIST MUSCLE FATIGUE IN HUMANS

Ballistic and accurately control of a targeted fast contraction relies on phasic activations of the agonist and antagonist muscles. The purpose of the study was to investigate the effect of tibialis anterior (TA) fatigue on the systematic bias and the consistence of the net dorsiflexion torque generation and the controlling pattern of the agonist-antagonist muscles. Ten subjects were tested twice with a week apart. Fast and slow dorsiflexion at 40%-MVG were measured before and after fatigue of the TA by voluntary isometric dorsiflexions. The EMG of the TA and soleus (Sol) were recorded. The results revealed that more post-fatigue increment of the systematic error was in the fast dorsiflexions, random error increment were similar in both speeds of isometric dorsiflexions, the cocontraction ratio increased after fatigue only in the slow dorsiflexions. Our results suggested that precision of the fast targeted isometric contractions was reduced after fatigue because of unvaried agonist-antagonist control strategy

THE EFFECT OF TWO DIFFERENT WEIGHTED BADMINTON RACKETS ABOUT VELOCITY AND TORQUE WHEN OUTSTANDING BADMINTON PLAYERS WAS PERFORMING SMASH MOVEMENT

The purpose of this research is to study and to analyze the relationship of the velocity and torque between two different weighted badminton rackets while the elite players was performing the smash movement .All the data of this study is filmed by digital video (60Hz/s) and is analyzed on the space of 20 by sagittal plane and horizontal axis movement of the participator .In order to derive \rom the primary parameters of smash motion, including velocity, movement of inertia, angular acceleration, torque. The data are digitized and filtered in APAS (the Ariel Performance Analyze System). As a result, by T-Test, the T-values are up to the observable level ,and the level a is 0.05

A rare complication in a child undergoing chemotherapy for acute lymphoblastic leukemia: Superior sagittal sinus thrombosis

AbstractWe report the case of a 4-year-old boy with acute lymphoblastic leukemia in high-risk group who suffered from generalized tonic-colonic seizure evolving into status epilepticus, and subsequent left hemiparesis during his first reinduction chemotherapy, consisting of dexamethasone, vincristine, l-asparaginase, and epirubicin. Superior sagittal sinus and cerebral venous thrombosis, predominantly in right side, were proved by brain magnetic resonance imaging. After aggressive treatment with low-molecular weight heparin (LMWH), left hemiparesis improved in 1 week. And he was fully ambulatory 3 weeks later. The second cycle of reinduction chemotherapy was conducted smoothly with the concomitant use of LMWH. This case illustrates the strong correlation of the rare thrombotic complication, superior sagittal sinus thrombosis, and hypercoagulable status secondary to combination use of l-asparaginase and corticosteroid. Early and vigilant recognition of superior sagittal sinus thrombosis and prompt anticoagulation with LMWH may prevent further neurological damage

Pathophysiology of Neuropathic Pain in Type 2 Diabetes: Skin denervation and contact heat–evoked potentials

OBJECTIVE: Neuropathic pain due to small-fiber sensory neuropathy in type 2 diabetes can be diagnosed by skin biopsy with quantification of intra- epidermal nerve fiber ( IENF) density. There is, however, a lack of noninvasive physiological assessment. Contact heat-evoked potential ( CHEP ) is a newly developed approach to record cerebral responses of A fiber- mediated thermonociceptive stimuli. We investigated the diagnostic role of CHEP. RESEARCH DESIGN AND METHODS: From 2006 to 2009, there were 32 type 2 diabetic patients (20 males and 12 females, aged 51.63 10.93 years) with skin denervation and neuropathic pain. CHEPs were recorded with heat stimulations at the distal leg, where skin biopsy was performed. RESULTS: CHEP amplitude was reduced in patients compared with age- and sex-matched control subjects (14.8 15.6 vs. 33.7 10.1 V, P < 0.001). Abnormal CHEP patterns ( reduced amplitude or prolonged latency) were noted in 81.3 % of these patients. The CHEP amplitude was the most significant parameter correlated with IENF density (P = 0. 003) and pain perception to contact heat stimuli (P = 0.019) on multiple linear regression models. An excitability index was derived by calculating the ratio of the CHEP amplitude over the IENF density. This excitability index was higher in diabetic patients than in control subjects (P = 0.023), indicating enhanced brain activities in neuropathic pain. Among different neuropathic pain symptoms, the subgroup with evoked pain had higher CHEP amplitudes than the subgroup without evoked pain (P = 0.011). CONCLUSIONS: CHEP offers a noninvasive approach to evaluate the degeneration of thermonociceptive nerves in diabetic neuropathy by providing physiological correlates of skin denervation and neuropathic pain

Autophagy Inhibition Enhances Apoptosis Induced by Dioscin in Huh7 Cells

Extensive research results support the application of herbal medicine or natural food as an augment during therapy for various cancers. However, the effect of dioscin on tumor cells autophagy has not been clearly clarified. In this study, the unique effects of dioscin on autophagy of hepatoma cells were investigated. Results found that dioscin induced caspase-3- and -9-dependent cell apoptosis in a dose-dependent manner. Moreover, inhibition of ERK1/2 phosphorylation significantly abolished the dioscin-induced apoptosis. In addition, dioscin triggered cell autophagy in early stages. With autophagy inhibitors to hinder the autophagy process, dioscin-induced cell apoptosis was significantly enhanced. An inhibition of caspase activation did not affect the dioscin-induced LC3-II protein expression. Based on the results, we believed that while apoptosis was blocked, dioscin-induced autophagy process also diminished in Huh7 cells. In conclusion, this study indicates that dioscin causes autophagy in Huh7 cells and suggests that dioscin has a cytoprotective effect