HCV genotypes, by HIV status, among 96 drug users in Liuzhou cohort.

<p>HCV genotypes, by HIV status, among 96 drug users in Liuzhou cohort.</p

Demographics, risk behaviors, and methadone use patterns of HIV/HCV coinfected and HCV monoinfected subjects in the study population (n = 112).

*<p>Missing data have been excluded.</p>a<p>Fisher's exact test.</p

HCV NS5B phylogenetic tree for drug users in Liuzhou, Guangxi, Southern China, with 96 drug users of which 20 are HIV/HCV co-infected (underlined).

<p>HCV NS5B phylogenetic tree for drug users in Liuzhou, Guangxi, Southern China, with 96 drug users of which 20 are HIV/HCV co-infected (underlined).</p

Multivariate logistic regression analysis for risk factors associated with HIV/HCV coinfection.

<p>Multivariate logistic regression analysis for risk factors associated with HIV/HCV coinfection.</p

HCV genotype 6a in the study population (n = 34) and other countries and regions.

<p>Codes for sources of samples: CN = China; TW = Taiwan; HK = Hong Kong VN = Vietnam.</p

Silencing <i>NDRG1</i> expression in PML^+/+ MEFs increases cell proliferation.

<p>(A & B) Cell cycle analysis of PML^+/+ MEFs transfected with CTL-siRNA and <i>NDRG1</i>-siRNA. (C) Bar chart showing that there were significantly more <i>NDRG1</i>-silenced MEFs distributed at S-phase than MEFs transfected with <i>CTL</i>-siRNAs. Inversely, there were also significantly less <i>NDRG1</i>-silenced MEFs distributed in the G0/G1 phase. The data are presented as mean±SD by t-test and *p<0.05.</p

PML^+/+ MEFs are significantly more mobile than PML^−/− MEFs.

<p>(A) In vitro scratch migration assay showing the extent that PML^+/+ and PML^−/− MEFs were able to migrate into the gap/space (defined by the dotted white lines) at different time intervals: 0, 4, 8 and 24 hrs. Scale bar = 500 µm. (B) Bar chart showing the percentage area of the gap that have been invaded by PML^+/+ and PML^−/− MEFs, at different time intervals. The experiment was repeated three times. Data is presented as Mean ± SD by t-test and *p<0.05.</p

Primer sequences used in the semi-quantitative RT-PCR Analysis.

<p>Primer sequences used in the semi-quantitative RT-PCR Analysis.</p

Validation of PML^−/− and PML^+/+ MEFs.

<p>(A) Western blot showing PML^−/− MEFs do not express PML protein. (B) Semi-quantitative RT-PCR also indicated that PML^−/− MEFs do not express <i>PML</i>. β-actin served as an internal control.</p

Identification of differentially down- regulated proteins in the 2DE.

<p>Identification of differentially down- regulated proteins in the 2DE.</p