Periodontal therapy reduces arginase activity in saliva of patients with chronic periodontitis

Made available in DSpace on 2019-09-12T16:53:26Z (GMT). No. of bitstreams: 0 Previous issue date: 2008This present study evaluated the salivary arginase activity (SAA) in patients with chronic periodontitis and the effect of periodontal therapy on the activity of such enzyme. Thirty-six patients (mean age, 45.97 +/- 14.52), 18 chronic periodontitis subjects (test group), and 18 periodontally healthy individuals (control group) participated in the study. Clinical periodontal examinations included measurements of probing pocket depth (PD), clinical attachment level (CAL), plaque (PI), and gingival (GI) indexes. The test group received periodontal therapy according to individual needs. The saliva sample was collected from all study population at baseline (both groups) and 30 days after periodontal therapy (test group). SAA was determined by measuring the L-ornithine formation from L-arginine and was expressed as mU/ml. The results showed that the mean values of SAA were statistically different between control and test groups. SAA was about 2.5 times higher in test than control groups. Thirty days after periodontal therapy, enzyme levels were 1.56 times lower than before periodontal therapy. We concluded that SAA is increased in chronic periodontitis subjects when compared to periodontally healthy individuals and that periodontal therapy significantly reduced SAA levels. It was' suggested that in the near future, SAA may be used as a salivary marker of periodontal status.[Gheren, L. W.; Hozhausen, M.] Universidade de Taubaté (Unitau), Dept Dent, BR-12010700 Taubate, SP, Brazil[Cortelli, J. R.] Universidade de Taubaté (Unitau), Dept Dent, Coordinat Periodont Res & Grad Studies Div[Rodrigues, E.] Universidade de Taubaté (Unitau), Dept Biol, Biochem Res & Grad Studies Div[Saad, W. A.] Universidade de Taubaté (Unitau), Physiol & Pharmacol Basic Inst Biosc