34 research outputs found
COBRA: a new European research project for organic plant breeding
Development of organic plant breeding and seed production will have a valuable impact on organic plant production. Breeding of plant material adapted for organic agriculture is crucial in order to cope with stresses such as climate change, weeds and seed borne diseases. Conventional varieties may not meet the specific needs of organic agriculture. The use of plant material adapted to conditions of organic agriculture will have a positive effect on the productivity and sustainability of organic crop production
Daily physical activity and macronutrient distribution of low-calorie diets jointly affect body fat reduction in obese women
AB deposition and related pathology in an APP x PS1 transgenic mouse model of Alzheimer s disease
Summary. A transgenic mouse bearing mutant
transgenes linked to familial forms of Alzheimer’s
disease (AD) for the amyloid precursor protein and
presenilin-1 (TASTPM) showed Aß plaque deposition
and age-related histological changes in associated brain
pathology. The Aß present was of multiple forms,
including species with a C-terminus at position 40 or 42,
as well as an N-terminus at position 1 or truncated in a
pyro-3-glutamate form. Endogenous rodent Aß was also
present in the deposits. Laser capture microdissection
extracts showed that multimeric forms of Aß were
present in both plaque and tissue surrounding plaques.
Associated with the Aß deposits was evidence of an
inflammatory response characterised by the presence of
astrocytes. Also present in close association with the
deposits was phosphorylated tau and cathepsin D
immunolabelling. The incidence of astrocytes and of
phosphorylated tau and cathepsin D load showed that
both of these potential disease markers increased in
parallel to the age of the mice and with Aß deposition.
Immunohistochemical labelling of neurons in the cortex
and hippocampus of TASTPM mice suggested that the
areas of Aß deposition were associated with the loss of
neurons. TASTPM mice, therefore, exhibit a number of
the pathological characteristics of disease progression in
AD and may provide a means for assessment of novel
therapeutic agents directed towards modifying or halting
disease progression
Diversity strategies for organic and low input agricultures and their food systems. Book of abstracts of SOLIBAM final congress, Nantes (FR), 7-9 July
Distribution of CB1 cannabinoid receptors and their relationship with mu-opioid receptors in the rat periaqueductal gray
The periaqueductal gray (PAG) is part of a descending pain modulatory system that, when activated, produces widespread and profound antinociception. Microinjection of either opioids or cannabinoids into the PAG elicits antinociception. Moreover, microinjection of the cannabinoid 1 (CB1) receptor agonist HU-210 into the PAG enhances the antinociceptive effect of subsequent morphine injections, indicating a direct relationship between these two systems. The objective of this study was to characterize the distribution of CB1 receptors in the dorsolateral and ventrolateral PAG in relationship to mu-opioid peptide (MOP) receptors. Immunocytochemical analysis revealed extensive and diffuse CB1 receptor labeling in the PAG, 60% of which was found in somatodendritic profiles. CB1 and MOP receptor immunolabeling were co-localized in 32% of fluorescent Nissl-stained cells that were analyzed. Eight percent (8%) of PAG neurons that were MOP receptor-immunoreactive received CB1 receptor-immunoreactive appositions. Ultrastructural analysis confirmed the presence CB1 receptor-immunoreactive somata, dendrites and axon terminals in the PAG. These results indicate that behavioral interactions between cannabinoids and opioids may be the result of cellular adaptations within PAG neurons co-expressing CB1 and MOP receptors