Seesaw scales and the steps from the Standard Model towards superstring-inspired flipped E_6

Recently in connection with Superstring theory E_8 and E_6 unifications became very promising. In the present paper we have investigated a number of available paths from the Standard Model (SM) to the E_6 unification, considering a chain of flipped models following the extension of the SM: SU(3)_C\times SU(2)_L\times U(1)_Y \to SU(3)_C\times SU(2)_L\times U(1)_X \times U(1)_Z \to SU(5)\times U(1)_X \to SU(5)\times U(1)_{Z1} \times U(1)_{X1} \to SO(10) \times U(1)_{X1} \to SO(10) \times U(1)_{Z2}\times U(1)_{X2} \to E_6\times U(1)_{X2} or E_6, Also we have considered a chain with a left-right symmetry: SU(3)_C\times SU(2)_L\times U(1)_Y \to SU(3)_C\times SU(2)_L \times SU(2)_R\times U(1)_X\times U(1)_Z \to SU(4)_C\times SU(2)_L \times SU(2)_R\times U(1)_Z \to SO(10)\times U(1)_Z \to E_6. We have presented four examples including non-supersymmetric and supersymmetric extensions of the SM and different contents of the Higgs bosons providing the breaking of the flipped SO(10) and SU(5) down to the SM. It was shown that the final unification E_6\times U(1) or E_6 at the (Planck) GUT scale M_{SSG} depends on the number of the Higgs boson representations considered in theory.Comment: 25 pages, 7 figure

Quantum decoherence of phonons in Bose–Einstein condensates

We apply modern techniques from quantum optics and quantum information science to Bose–Einstein condensates(BECs)in order to study, for the first time, the quantum decoherence of phonons of isolated BECs. In the last few years, major advances in the manipulation and control of phonons have highlighted their potential as carriers of quantum information in quantum technologies, particularly in quantum processing and quantum communication. Although most of these studies have focused on trapped ion and crystalline systems, another promising system that has remained relatively unexplored is BECs. The potential benefits in using this system have been emphasized recently with proposals of relativistic quantum devices that exploit quantum states of phonons in BECs to achieve, in principle, superior performance over standard non-relativistic devices. Quantum decoherence is often the limiting factor in the practical realization of quantum technologies, but here we show that quantum decoherence of phonons is not expected to heavily constrain the performance of these proposed relativistic quantum devices

Combinatorial targeting and discovery of ligand-receptors in organelles of mammalian cells

Phage display screening allows the study of functional protein–protein interactions at the cell surface, but investigating intracellular organelles remains a challenge. Here we introduce internalizing-phage libraries to identify clones that enter mammalian cells through a receptor-independent mechanism and target-specific organelles as a tool to select ligand peptides and identify their intracellular receptors. We demonstrate that penetratin, an antennapedia-derived peptide, can be displayed on the phage envelope and mediate receptor-independent uptake of internalizing phage into cells. We also show that an internalizing-phage construct displaying an established mitochondria-specific localization signal targets mitochondria, and that an internalizing-phage random peptide library selects for peptide motifs that localize to different intracellular compartments. As a proof-of-concept, we demonstrate that one such peptide, if chemically fused to penetratin, is internalized receptor-independently, localizes to mitochondria, and promotes cell death. This combinatorial platform technology has potential applications in cell biology and drug development