Computer program development for the analysis of inelastic beam and soil behaviour in geotechnical design

Computer-aided engineering requires the correct implementation of design methods in computer programs so as to play a beneficial role in engineering practice. This thesis describes the development of a computer program to analyse geotechnical engineering problems based on the principles of beam-soil interaction where the beam is supported by a single or two-layer soil system. In 1867, a foundation model was proposed by Winkler in which the elastic foundation beneath a horizontal beam could be viewed as a series of independent springs. Foundation reaction to beam deflection is, therefore, linear. A stiffness matrix, for use in matrix methods of structural analysis, has been developed to define this beam-soil interaction, and such a method can be incorporated into a computer program. Furthermore, an iterative technique was created to allow for inelastic soil response when using the elastic stiffness matrix. However, such a technique did not consider realistic soil behaviour, and has limitations is used for practical design. This research' work describes how use can be made of the pressure-displacement response relationship for a soil to bring greater realism to beam-soil modelling and analysis. Such a relationship is commonly determined in geotechnical design procedures through a plate load test in the field. In addition, the iterative technique is extended to include non-linear beam behaviour as well, and plastic hinging of the beam material is incorporated to enable limitation of inelastic response. While previous research has only considered foundations of a single soil only, a procedure to model a two-layered system is developed. Two-layered foundations are required for proper modelling of soldier pile support systems, an area of structural design in geotechnics chosen to demonstrate realistic design potential for the computer program. The two-layered principle is based on the derivation of a control parameter to differentiate between response from just the upper soil layer, and a combined response from both soil layers. The procedure is relatively simple, and no extra information is required other than the two pressure displacement relationships for the individual soil layers. A desktop computer program is described which incorporates the inelastic analysis features, as well as the two-layered soil system. The program makes use of a graphical user interface to offer the user an easy, interactive environment for analysing beam-on-soil foundation problems. As such, the program can be used directly, or for further research into beam-soil interaction. The program is applied in the analysis of both field and laboratory tests to ascertain its accuracy in predicting beam-soil interaction. The laboratory test measures the deflection of a horizontal beam on a single soil foundation medium, where the beam is loaded by a single jack at approximately mid-span. Computer predictions for such a test were in very close agreement with the laboratory observations, despite the small magnitude of beam displacements, and the fact the beam-soil system suffered a bearing capacity failure which affected the beam deflection. The field test was performed to investigate the performance of a flexible soldier pile under high anchor loading. Results of the computer analyses again show the program's predictions to be in very close agreement with the field measurements. Currently, the program does not include the facility to model soil layers behind a soldier pile, but the method developed in this thesis can easily incorporate multiple pressure-displacement curves for different soils. Final conclusions drawn express a need for more research into soldier pile systems before the techniques of this work can be used for routine design. Nevertheless, the development of the program has made a significant contribution to advancing the use of computer-aided design in this field of geotechnical engineering

'Mine's a Pint of Bitter': Performativity, gender, class and representations of authenticity in real-ale tourism

Leisure choices are expressive of individual agency around the maintenance of taste, boundaries, identity and community. This research paper is part of a wider project designed to assess the social and cultural value of real ale to tourism in the north of England. This paper explores the performativity of real-ale tourism and debates about belonging in northern English real-ale communities. The research combines an ethnographic case study of a real-ale festival with semi-structured interviews with organisers and volunteers, northern English real-ale brewers and real-ale tourists visiting the festival. It is argued that real-ale tourism, despite its origins in the logic of capitalism, becomes a space where people can perform Habermasian, communicative leisure, and despite the contradictions of preferring some capitalist industries over others on the basis of their perceived smaller size and older age, real-ale fans demonstrate agency in their performativity

Plasmons in Scanning Transmission Electron Microscopy Electron Spectra

A general self-energy formulation of the interaction between an electron in a scanning transmission electron microscope (STEM) and a localized target is given. We prove a theorem relating the probability of energy transfer to that calculated classically. Local dielectric theory of target excitation for various geometries is discussed. The problem of localization of initially unlocalized excitations in the valence band of solids is treated by transforming cross sections differential in momentum transfer into dependence on an impact parameter variable. We are thereby able to account for experimental data in scanning electron microscopy (SEM) that show high spatial resolution

Integrating palliative care and heart failure: a systematic realist synthesis (PalliatHeartSynthesis)

Objectives (1) Develop a programme theory of why, for whom and in what contexts integrated palliative care (PC) and heart failure (HF) services work/do not work; (2) use the programme theory to co-produce with stakeholders, intervention strategies to inform best practice and future research. Methods A systematic review of all published articles and grey literature using a realist logic of analysis. The search strategy combined terms significant to the review questions: HF, PC and end of life. Documents were included if they were in English and provided data relevant to integration of PC and HF services. Searches were conducted in November 2021 in EMBASE, MEDLINE, PsycINFO, AMED, HMIC and CINAHL. Further relevant documents were identified via monthly alerts (up until April 2023) and the project stakeholder group (patient/carers, content experts and multidisciplinary practitioners). Results 130 documents were included (86 research, 22 literature reviews, 22 grey literature). The programme theory identified intervention strategies most likely to support integration of PC and HF services. These included protected time for evidence-based PC and HF education from undergraduate/postgraduate level and continuing professional practice; choice of educational setting (eg, online, face-to-face or hybrid); increased awareness and seeing benefits of PC for HF management; conveying the emotive and intellectual need for integrating PC and HF via credible champions; and prioritising PC and HF guidelines in practice. Conclusions The review findings outline the required steps to take to increase the likelihood that all key players have the capacity, opportunity and motivation to integrate PC into HF management. PROSPERO registration number CRD42021240185

Susceptibility to tuberculosis is associated with variants in the ASAP1 gene encoding a regulator of dendritic cell migration

Human genetic factors predispose to tuberculosis (TB). We studied 7.6 million genetic variants in 5,530 people with pulmonary TB and in 5,607 healthy controls. In the combined analysis of these subjects and the follow-up cohort (15,087 TB patients and controls altogether), we found an association between TB and variants located in introns of the ASAP1 gene on chromosome 8q24 (P = 2.6 × 10−11 for rs4733781; P = 1.0 × 10−10 for rs10956514). Dendritic cells (DCs) showed high ASAP1 expression that was reduced after Mycobacterium tuberculosis infection, and rs10956514 was associated with the level of reduction of ASAP1 expression. The ASAP1 protein is involved in actin and membrane remodeling and has been associated with podosomes. The ASAP1-depleted DCs showed impaired matrix degradation and migration. Therefore, genetically determined excessive reduction of ASAP1 expression in M. tuberculosis–infected DCs may lead to their impaired migration, suggesting a potential mechanism of predisposition to TB

High-temperature phase transitions in dense germanium.

Through a series of high-pressure x-ray diffraction experiments combined with in situ laser heating, we explore the pressure-temperature phase diagram of germanium (Ge) at pressures up to 110 GPa and temperatures exceeding 3000 K. In the pressure range of 64-90 GPa, we observe orthorhombic Ge-IV transforming above 1500 K to a previously unobserved high-temperature phase, which we denote as Ge-VIII. This high-temperature phase is characterized by a tetragonal crystal structure, space group I4/mmm. Density functional theory simulations confirm that Ge-IV becomes unstable at high temperatures and that Ge-VIII is highly competitive and dynamically stable at these conditions. The existence of Ge-VIII has profound implications for the pressure-temperature phase diagram, with melting conditions increasing to much higher temperatures than previous extrapolations would imply

Synthesis of Superconducting Cobalt Trihydride

The Co–H system has been investigated through high-pressure, high-temperature X-ray diffraction experiments combined with first-principles calculations. On compression of elemental cobalt in a hydrogen medium, we observe face-centered cubic cobalt hydride (CoH) and cobalt dihydride (CoH2) above 33 GPa. Laser heating CoH$_2$ in a hydrogen matrix at 75 GPa to temperatures in excess of ∼800 K produces cobalt trihydride (CoH$_3$) which adopts a primitive structure. Density functional theory calculations support the stability of CoH$_3$. This phase is predicted to be thermodynamically stable at pressures above 18 GPa and to be a superconductor below 23 K. Theory predicts that this phase remains dynamically stable upon decompression above 11 GPa where it has a maximum Tc of 30 K

High-temperature phase transitions in dense germanium.

Through a series of high-pressure x-ray diffraction experiments combined with in situ laser heating, we explore the pressure-temperature phase diagram of germanium (Ge) at pressures up to 110 GPa and temperatures exceeding 3000 K. In the pressure range of 64-90 GPa, we observe orthorhombic Ge-IV transforming above 1500 K to a previously unobserved high-temperature phase, which we denote as Ge-VIII. This high-temperature phase is characterized by a tetragonal crystal structure, space group I4/mmm. Density functional theory simulations confirm that Ge-IV becomes unstable at high temperatures and that Ge-VIII is highly competitive and dynamically stable at these conditions. The existence of Ge-VIII has profound implications for the pressure-temperature phase diagram, with melting conditions increasing to much higher temperatures than previous extrapolations would imply

Experiences of refugees and asylum seekers in general practice: a qualitative study

Background: There has been much debate regarding the refugee health situation in the UK. However most of the existing literature fails to take account of the opinions of refugees themselves. This study was established to determine the views of asylum seekers and refugees on their overall experiences in primary care and to suggest improvements to their care. Methods: Qualitative study of adult asylum seekers and refugees who had entered the UK in the last 10 years. The study was set in Barnet Refugee Walk in Service, London. 11 Semi structured interviews were conducted and analysed using framework analysis. Results: Access to GPs may be more difficult for failed asylum seekers and those without support from refugee agencies or family. There may be concerns amongst some in the refugee community regarding the access to and confidentiality of professional interpreters. Most participants stated their preference for GPs who offered advice rather than prescriptions. The stigma associated with refugee status in the UK may have led to some refugees altering their help seeking behaviour. Conclusion: The problem of poor access for those with inadequate support may be improved by better education and support for GPs in how to provide for refugees. Primary Care Trusts could also supply information to newly arrived refugees on how to access services. GPs should be aware that, in some situations, professional interpreters may not always be desired and that instead, it may be advisable to reach a consensus as to who should be used as an interpreter. A better doctor-patient experience resulting from improvements in access and communication may help to reduce the stigma associated with refugee status and lead to more appropriate help seeking behaviour. Given the small nature of our investigation, larger studies need to be conducted to confirm and to quantify these results