182 research outputs found

    Picasso on Staff: Employee Classification, Copyrights, and the Creative Process

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    Appraisal -Tendency Framework: Emotions and Perceptions of Social Injustice

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    This research project studies the Appraisal-Tendency Framework. Specifically, it observes whether emotional dispositions, such as sadness-proneness or trait anger, affect judgements made on whether a situation is just or unjust. In addition, this study also presents the question of whether gender impacts perceptions of fairness. All participants will be recruited from a Southeastern University. This study consists of two parts. For part one, all participants will complete an online survey to assess individual differences. Part two contains the experimental manipulations. This study uses a 2 (emotional induction) x 2 (gender of actor) design. For the emotional induction, participants will be randomly assigned to view a clip meant to induce feelings of sadness or feelings of anger. All participants will be asked to write a short response of a real-life emotional experience matching the emotion of the condition they are assigned to. They will then be randomly assigned to view a clip of an unjust situation carried out by either a female professor or a male professor. The outcome of this study could provide organizations with a better understanding of why certain emotions relate to certain judgements and decisions

    Myosin IIA-mediated forces regulate multicellular integrity during vascular sprouting

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    Angiogenic sprouting is a critical process involved in vascular network formation within tissues. During sprouting, tip cells and ensuing stalk cells migrate collectively into the extracellular matrix while preserving cell-cell junctions, forming patent structures that support blood flow. Although several signaling pathways have been identified as controlling sprouting, it remains unclear to what extent this process is mechanoregulated. To address this question, we investigated the role of cellular contractility in sprout morphogenesis, using a biomimetic model of angiogenesis. Three-dimensional maps of mechanical deformations generated by sprouts revealed that mainly leader cells, not stalk cells, exert contractile forces on the surrounding matrix. Surprisingly, inhibiting cellular contractility with blebbistatin did not affect the extent of cellular invasion but resulted in cell-cell dissociation primarily between tip and stalk cells. Closer examination of cell-cell junctions revealed that blebbistatin impaired adherens-junction organization, particularly between tip and stalk cells. Using CRISPR/Cas9-mediated gene editing, we further identified NMIIA as the major isoform responsible for regulating multicellularity and cell contractility during sprouting. Together, these studies reveal a critical role for NMIIA-mediated contractile forces in maintaining multicellularity during sprouting and highlight the central role of forces in regulating cell-cell adhesions during collective motility.R01 EB000262 - NIBIB NIH HHS; R01 HL115553 - NHLBI NIH HHSPublished versio

    Factors influencing the delivery of telerehabilitation for stroke: a systematic review

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    ObjectiveDespite the available evidence regarding effectiveness of stroke telerehabilitation, there has been little focus on factors influencing its delivery or translation from the research setting into practice. There are complex challenges to embedding telerehabilitation into stroke services and generating transferable knowledge about scaling up and routinising this service model. This review aimed to explore factors influencing the delivery of stroke telerehabilitation interventions, including platforms, technical requirements, training, support, access, cost, usability and acceptability.MethodsMEDLINE, EMBASE, CINAHL, Web of Science and Cochrane Library and Central Registry of Clinical Trials were searched to identify full-text articles of randomised controlled trials (RCTs) and protocols for RCTs published since a Cochrane review on stroke telerehabilitation services. A narrative synthesis was conducted, providing a comprehensive description of the factors influencing stroke telerehabilitation intervention delivery.ResultsThirty-one studies and ten protocols of ongoing studies were included. Interventions were categorised as synchronous telerehabilitation (n = 9), asynchronous telerehabilitation (n = 11) and tele-support (n = 11). Telephone and videoconference were the most frequently used modes of delivery. Usability and acceptability with telerehabilitation were high across all platforms, although access issues and technical challenges may be potential barriers to the use of telerehabilitation in service delivery. Costs of intervention delivery and training requirements were poorly reported.ConclusionsThis review synthesises the evidence relating to factors that may influence stroke telerehabilitation intervention delivery at a crucial timepoint given the rapid deployment of telerehabilitation in response to the COVID-19 pandemic. It recommends strategies, such as ensuring adequate training and technical infrastructure, shared learning and consistent reporting of cost and usability and acceptability outcomes, to overcome challenges in embedding and routinising this service model and priorities for research in this area
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