Asia’s Wicked Environmental Problems

The developing economies of Asia are confronted by serious environmental problems that threaten to undermine future growth, food security, and regional stability. This study considers four major environmental challenges that policymakers across developing Asia will need to address towards 2030: water management, air pollution, deforestation and land degradation, and climate change. We argue that these challenges, each unique in their own way, all exhibit the characteristics of “wicked problems”. As developed in the planning literature, and now applied much more broadly, wicked problems are dynamic, complex, encompass many issues and stakeholders, and evade straightforward, lasting solutions.asia environmental problems; food security; water management; air pollution; deforestation; land degradation; climate change; wicked problems

Street slang and schizophrenia

We report the case of a 26 year old streetwise young postman who presented with a six month history of reduced occupational and social function, low mood, and lack of motivation. He complained of feeling less sociable and less interested in his friends and of being clumsy and finding it harder to think. He was otherwise fit and healthy, with no physical abnormalities, neurological signs, or objective cognitive impairments. There was no history of a recent stressor that might have precipitated his symptoms. He was referred to a specialist service for patients in the prodromal phase of psychotic illness for further assessment after he had seen his general practitioner and the local community mental health team. The differential diagnosis at this stage was depression, the prodrome of schizophrenia, or no formal clinical disorder. His premorbid occupational and social function had been good. There was no history of abnormal . social, language, and motor development and he left school with two A levels. After three years of service at the post office he had been promoted to a supervisory role. He had a good relationship with his family and had six or so good friends. There has been a number of previous heterosexual relationships, although none in the past year. Aside from smoking cannabis on two occasions when he was 19, there was no history of illicit substance use. Detailed and repeated assessment of his mental state found a normal affect, no delusions, hallucinations, or catatonia, and no cognitive dysfunction. His speech, however, was peppered with what seemed (to his middle class and older psychiatrist) to be an unusual use of words, although he said they were street slang (table).Go It was thus unclear whether he was displaying subtle signs of formal thought disorder (manifest as disorganised speech, including the use of unusual words or phrases, and neologisms) or using a "street" argot. This was a crucial diagnostic distinction as thought disorder is a feature of psychotic illnesses and can indicate a diagnosis of schizophrenia. We sought to verify his explanations using an online dictionary of slang (urbandictionary.com). To our surprise, many of the words he used were listed and the definitions accorded with those he gave (see table). We further investigated whether his speech showed evidence of thought disorder by examining recordings of his speech as he described a series of ambiguous pictures from the thematic apperception test, a procedure that elicits thought disordered speech. His speech was transcribed and rated with the thought and language index, a standardised scale for assessing thought disorder. Slang used in a linguistically appropriate way is not scored as abnormal on this scale. His score was 5.25, primarily reflecting a mild loosening of associations. For example, he described a picture of a boat on a lake thus: "There’s a boat and a tree. There seems to be a reflection. There are no beds, and I wonder why there are no beds. There’s a breeze going through the branches of the tree." His score was outside the normal range (mean for normal controls 0.88, SD 1.15) and indicates subtle thought disorder, equivalent to that evident in remitted patients with schizophrenia (mean in remitted patients 3.89, SD 2.56) but lower than that in patients with formal thought disorder (mean 27.4, SD 8.3). Over the following year his social and occupational functioning deteriorated further, and he developed frank formal thought disorder as well as grandiose and persecutory delusions to the extent that he met DSM-IV criteria for schizophrenia. His speech was assessed as before, and the thought and language index score had increased to 11.75. This mainly reflected abnormalities on items comprising "positive" thought disorder, particularly the use of neologisms such as "chronocolising" and non-sequiturs. To our knowledge this is the first case report to describe difficulties in distinguishing "street" argots from formal thought disorder. It is perhaps not surprising that slang can complicate the assessment of disorganised speech as psychotic illnesses usually develop in young adults, whereas the assessing clinician is often from an older generation (and different sociocultural background) less familiar with contemporary urban slang. Online resources offer a means of distinguishing street argot from neologisms or a peculiar use of words, and linguistic rating scales may be a useful adjunct to clinical assessment when thought disorder is subtle. Differentiating thought disorder from slang can be especially difficult in the context of "prodromal" signs of psychosis, when speech abnormalities, if present, are usually subtle. Nevertheless, accurate speech assessment is important as subtle thought disorder can, as in this case, predate the subsequent onset of schizophrenia, and early detection and treatment of psychosis might be associated with a better long term clinical outcome

Evapotranspiration from Natural Vegetation in the Central Valley of California: Monthly Grass Reference-Based Vegetation Coefficients and the Dual Crop Coefficient Approach

Restoration activities in the Central Valley of California and elsewhere require accurate evapotranspiration information, which can then be used for a wide variety of surface and subsurface hydrologic evaluations. However, directly measuring evapotranspiration can be difficult or impossible depending on the evaluation’s time frame. Transferability of measured evapotranspiration in time and space is also necessary but typically requires a weather-based reference. For nonagricultural vegetation, there is at present time no standard reference, which makes the evaluation of a variety of vegetation types from different sources difficult and time-consuming. This paper examines several methods used to estimate evapotranspiration from native vegetation, including the use of vegetation coefficients (Kv). Vegetation coefficients are based on a standardized reference and are computed as the ratio of vegetation evapotranspiration (ETv) to the grass reference evapotranspiration (ETo). These monthly Kvvalues are used to compute the long-term (for this study, 1922–2009) average ETvfor vegetation types documented to exist in California’s Central Valley prior to the arrival of the first European settlers in the mid-18th century. For vegetation that relies on precipitation and soil moisture storage, a calibrated daily soil–water balance with a dual crop coefficient approach was used to compute evapotranspiration regionally over the time frame

A 17O nuclear magnetic resonance study of high temperature superconductors

¹⁷O Nuclear magnetic resonance is an ideal probe of the high temperature superconductors as it can sample both the static and dynamic electronic susceptibilities of the Cu-O planes of these materials. The ¹⁷O NMR site assignments and the temperature dependence of the shift and spin-lattice relaxation has been investigated for the n = 1 and 3 phases of Bi2Sr2Can-1CunO4+2n and the n=3 phase of Tl2Ba2Can-1CunO4+2n. The shift of the ¹⁷O resonance associated with the Cu-O plane of the non-superconducting Bi2Sr2CuO6 is temperature independent from room temperature to 5K. This is not the situation for Bi2Sr2Ca2Cu3O10 and Tl2Ba2Ca2Cu3O10. For the Bi2Sr2Ca2Cu3O10 superconductor (Tc » 107K) both of the distinct Cu- O planes of the unit cell show a marked but different temperature dependence of the NMR shift above Tc. The shift associated with the central Cu-O plane starts to decrease below - 300K and the spin component of the Knight shift has dropped to -1/2 of its room temperature value by Tc. The outer Cu-O plane shift is almost temperature independent until - 120K when it decreases sharply and the spin component of the Knight shift is -2/3 of its room temperature value by Tc. The difference in these temperature dependencies suggests that a one component susceptibility model cannot describe this system. The Tl2Ba2Ca2Cu3O10 superconductor is structurally very similar to Bi2Sr2Ca2Cu3O10. The ¹⁷O NMR shift has been studied for this sample before an annealing process (Tc = 114K) and after (Tc= 124K). The room temperature resonances observed before and after the anneal are essentially the same. Interestingly the resonances observed for the two distinct Cu-O planes of the structure have very similar shift values and cannot be easy resolved (unlike the situation for Bi2Sr2Ca2Cu3O10). Before and after annealing a temperature dependence of the resonance associated with the Cu-O planes is observed but in contrast to Bi2Sr2Ca2Cu3O10 the two different plane resonances show the same temperature dependencies. Before the anneal the spin component of the shift is estimated to be — 2/3 of its room temperature value by Tc whereas after the anneal the shift has drooped to - 1/6 of its room temperature value by Tc. For both Bi2Sr2Ca2Cu3O10 and Tl2Ba2Ca,Cu3O.0 the relaxation behaviour of the Cu-O planes appears to be Korringa like (Kn2T1T is constant) in the normal state despite these temperature dependent shifts. The values obtained for Kn2T1T is similar to the theoretical value for simple s-type metals with no electron-electron or antiferromagnetic interaction. However the data does not completely rule out any other relaxation behaviou

Identification of a Novel GABAA Receptor Channel Ligand Derived from Melissa officinalis and Lavandula angustifolia Essential Oils

Aims: Melissa officinalis (Mo) and Lavandula angustifolia (La) essential oils and their major constituents ((E) - caryophyllene, caryophyllene oxide, geranyl acetate, linalool, nerol, Oct-1-en-3-ol, 3-Octanone, myrcene, allo-ocimene, p-cymene and α- terpineol) assessed by GC-MS) which are shared by these two essential oils were probed in an attempt to identify the GABAAR ligand(s). Study Design: [35S] t-butylbicyclophosphorothionate (TBPS) radioligand binding assay to GABAA receptors. In vitro neuronal viability assay. Place and Duration of Study: School of Biological and Biomedical Sciences, Durham University, United Kingdom (December 2012 and January 2013). Results: One of the major component (s) of (Mo), trans-ocimene, inhibited [35S] (TBPS) binding to native GABAA receptors in a concentration-dependent manner with an apparent IC50 of 40μM. Concentrations (0.001 mg/ml) of whole (Mo) were shown to display modest beneficial effects upon neuronal viability while at a higher concentration (0.1 mg/ml) of (Mo) and (La) oils induced a neurotoxicity effect. Conclusion: These data provide the first evidence that allo-ocimene is an neuroactive GABAA R inhibitory component found in both (Mo) and (La), and represents a novel GABAA receptor channel chemotype derived from a natural product. - See more at: http://www.sciencedomain.org/abstract.php?iid=474&id=13&aid=4142#.VCFGHBbQpv

Factors influencing the delivery of telerehabilitation for stroke: a systematic review

ObjectiveDespite the available evidence regarding effectiveness of stroke telerehabilitation, there has been little focus on factors influencing its delivery or translation from the research setting into practice. There are complex challenges to embedding telerehabilitation into stroke services and generating transferable knowledge about scaling up and routinising this service model. This review aimed to explore factors influencing the delivery of stroke telerehabilitation interventions, including platforms, technical requirements, training, support, access, cost, usability and acceptability.MethodsMEDLINE, EMBASE, CINAHL, Web of Science and Cochrane Library and Central Registry of Clinical Trials were searched to identify full-text articles of randomised controlled trials (RCTs) and protocols for RCTs published since a Cochrane review on stroke telerehabilitation services. A narrative synthesis was conducted, providing a comprehensive description of the factors influencing stroke telerehabilitation intervention delivery.ResultsThirty-one studies and ten protocols of ongoing studies were included. Interventions were categorised as synchronous telerehabilitation (n = 9), asynchronous telerehabilitation (n = 11) and tele-support (n = 11). Telephone and videoconference were the most frequently used modes of delivery. Usability and acceptability with telerehabilitation were high across all platforms, although access issues and technical challenges may be potential barriers to the use of telerehabilitation in service delivery. Costs of intervention delivery and training requirements were poorly reported.ConclusionsThis review synthesises the evidence relating to factors that may influence stroke telerehabilitation intervention delivery at a crucial timepoint given the rapid deployment of telerehabilitation in response to the COVID-19 pandemic. It recommends strategies, such as ensuring adequate training and technical infrastructure, shared learning and consistent reporting of cost and usability and acceptability outcomes, to overcome challenges in embedding and routinising this service model and priorities for research in this area