Hazard ratios and 95% confidence intervals for risk of death according to BMI category (40.0–59.9 versus 18.5–24.9 kg/m²) or continuous values of BMI between 40.0 and 59.9 kg/m² (per 5 kg/m²): subgroup analyses.

<p>*Calculated by including a cross-product term between the subgroup variable and BMI (40.0–59.9 versus 18.5–24.9 kg/m²); subgroup analyses for attained age and calendar year were stratified by follow-up period.</p>a<p>Models use attained age as the underlying time metric, and are adjusted for sex, race/ethnicity (white [all participants in the Swedish and Australian cohorts were coded as white], black, Asian/Pacific Islander, Hispanic, other/unknown), education (high school or less, post–high school, college, unknown), alcohol intake (grams of ethanol per day: 0, >0 to <10, ≥10, unknown), physical activity level (cohort-specific tertiles corresponding to low, medium, and high), and study.</p>b<p>Models excluded participants who entered the study at or after age 65 y; follow-up time was censored at age at study exit (due to loss to follow-up, death, or administrative end date) or age 65 y, whichever came first.</p>c<p>Models excluded participants who exited the study at or before age 65 y; follow-up began at age 65 y for those who entered the study before age 65 y.</p>d<p>Models excluded participants who entered the study on or after the year 2000; follow-up time was censored at study exit (due to loss to follow-up, death, or administrative end date) or the year 2000, whichever came first.</p>e<p>Models excluded participants who exited the study on or before the year 2000; follow-up began in the year 2000 for those who entered the study before the year 2000.</p

Description of participants with BMI in the normal-weight (18.5–24.9 kg/m²) and class III obesity (40.0–59.0 kg/m²) range, by cohort.

<p>Description of participants with BMI in the normal-weight (18.5–24.9 kg/m²) and class III obesity (40.0–59.0 kg/m²) range, by cohort.</p

Age-adjusted cause-specific mortality rates (number of deaths per 100,000 persons per year) by BMI category.

<p>Mortality rates were age-standardized using the age distribution of adults aged 20–84 y in the 2000 US census population; not shown if calculations based on fewer than five deaths in the BMI 40.0–59.9 kg/m² group.</p><p>*<i>p</i><0.05;</p><p>** <i>p</i><0.001.</p><p>ICD-10, International Classification of Diseases, tenth revision; n/a, not applicable.</p

Hazard ratios and 95% confidence intervals for risk of death by BMI category.

a<p>Models use attained age as the underlying time metric and were adjusted for sex and study.</p>b<p>Models use attained age as the underlying time metric, and are adjusted for sex, race/ethnicity (white [all participants in the Swedish and Australian cohorts were coded as white], black, Asian/Pacific Islander, Hispanic, other/unknown), education (high school or less, post–high school, college, unknown), alcohol intake (grams of ethanol per day: 0, >0 to <10, ≥10, unknown), physical activity level (cohort-specific tertiles corresponding to low, medium, and high), and study.</p>c<p>Using BMI = 40.0–44.9 kg/m² as the reference group.</p

Epigenomic marks indicating enhancer activity at the 5q22 locus.

<p>Histone marks in samples from the ROADMAP Epigenomics Project at the enhancer overlapping the lead SNP rs9885413 in heart tissue (left ventricle) and in tissues with evidence of an active enhancer at the locus. Histone marks are monomethylation (H3K4Me1) of the fourth residue (lysine) and acetylation of the 27th residue (H3K27Ac) of histone H3. Positions refer to NCBI build 36.</p

Characteristics of cohorts in stage 1.

<p>Characteristics of cohorts in stage 1.</p

Association of genetic polymorphisms with HF mortality.

<p>Association of genetic polymorphisms with HF mortality.</p

Regional association plot for HF mortality at the 5q22 locus.

<p>The plot covers the genomic region from 450 kb upstream of the SNP to 650 kb downstream. Diamonds represent SNPs. The large black diamond represents the SNP with the lowest <i>P</i>-value (rs9885413), with the <i>P</i>-value from the combined meta-analysis presented. Diamond color represents strength of pairwise correlation with the strongest SNP. Red represents r² ≥ 0.8, orange represents r² 0.5–0.8, yellow represents r² 0.2–0.5, and white represents r² < 0.2. Recombination rate is plotted in the background and known genes are represented in the bottom of the plot. Positions refer to NCBI build 36. SNP correlations and recombination rates were obtained from HapMap release 22.</p