Oxidation of glucose by iodine in the presence of insulin

This investigation was undertaken with the purpose of determining whether insulin, alone or in the presence of certain animal fluids, has any influence upon glucose in vitro. The establishment of such an influence might have much significance in relation both to the study of carbohydrate metabolism and to the development of methods of assaying insulin

Career Exploration at the Middle School Level: Barriers and Opportunities

In this essay, we discuss issues related to the integration of career exploration in our nation’s middle schools. We discuss the theoretical and empirical basis for career exploration at the middle school level and identify selected barriers to its effective implementation, namely with regards to career advising and parent involvement. We also propose new directions for practice and research as we work to counteract these barriers

95th Connecticut College Commencement Address

Emmy-winning television writer and producer Howard Gordon told the Class of 2013, The fictional characters I create live in the same crazy, complicated world as the rest of us. How they navigate through the world is what makes them compelling. How you navigate your way through the world is what will make your story compelling.” The best way to do it, he told the Class of 2013, is to heed the sage words of advice printed on the poster in his office: “Work hard and be nice to people.” He apologized for what may sound like fortune-cookie philosophy, but said the seven-word sentence inspires him every day. Working hard will not guarantee success, he told the graduates, “But I have yet to meet a successful person who hasn’t worked hard.” Being nice, he added, is in many ways about listening to others. “Listening takes practice, and it takes patience. But I promise, if you listen, your story will be better for it.

Quality Indicators Guiding Secondary Career and Technical Education Programs of Study

The purpose of this study was to examine quality indicators currently guiding the rigor of secondary career and technical education (CTE) programs of study in the United States. Quality indicators are desirable characteristics or expectations for a comprehensive and effective CTE program of study. As of May 2017, we were able to locate publicly accessible secondary CTE quality program standards/guidelines for 38 states. A majority (n=24) updated their secondary CTE quality program standards/guidelines within the last five years (i.e., 2012-2017). Deductive content analysis was conducted to examine the 38 state profiles using the Association of Career and Technical Education (ACTE) Quality CTE Program of Study Framework 4.0 for coding purposes. Common quality elements and key quality indicators were identified from those state documents, which supplements the ACTE Framework. Implications and examples for practice are also discussed

Understanding Reading First: What We Know, What We Don't, and What's Next

Studies of Reading First released in 2008 found no overall effect on student reading comprehension, and the program was eliminated in 2009. However, the research findings were more nuanced than was widely reported, and they offer lessons for policymakers making critical choices today about how the federal government can best support the teaching of reading to young children

Cognitive Process in Observational Learning

Recent theories of observational learning often make a distinction between the acquisition and the performance of new behaviors, yet these theoretical models invariably develop and test hypothetical acquisition processes using performance of the modeled behaviors as the independent variable, thereby introducing uncontrolled performance variables which potentially contaminate experimental results and increase the uncertainty of the conclusions. This study employed paired-associate learning tasks using modeled discrete actions and printed words as stimuli paired with two-digit numbers as the responses which are learned. The learning tasks were presented on film. Since the learned behavioral responses were numbers, rather than modeled behaviors, variables affecting performance of modeled behaviors were eliminated. Three groups of action and word pairs were used. All actions were athletically oriented and involved a ball (e.g., throwing). The same group actions and the common words used to describe the actions were each presented 15 times and paired with identical responses. The different group actions and their word equivalents were paired with different numbers

The Programmed Text as an Aid to Teaching Spelling in Junior High School

Organized education, historically, has been slow to commit itself to any sort of intensive examination of how learning can be both analyzed and substantially improved. But today Komoski (1960) tells us that we are looking beyond the traditional approaches to teaching. If a newly developed method is shown to be more effective than the techniques which have traditionally been employed, it is carefully considered for incorporation into the current education program. Programmed instruction is just such an example of a recently developed teaching method which claims it will contribute much to education. It dates back to Pressey\u27s report (1926) of a simple teaching device which also gave tests and scores. Extensive research into this method, however, has occurred only during the past ten or twelve years. The intense interest in programmed instruction is understandable when we consider the goals of education in this country. The chief aim of education is to help each student achieve his fullest potential. The schools can best accomplish this by helping each student to recognize his own capacities, and by using methods which will contribute to an individual\u27s developing intrinsically within himself the motivation for learning. However, there are present-day pressures which hamper the realization of these goals. Today the world is confronted with a population rise unprecedented in history. This population explosion is clearly reflected in the burgeoning school enrollments and the accompanying problems of inadequate classroom space and limited facilities. Unfortunately, the consequences of these pressures prove consistently detrimental to the establishment of an ideal educational system. For example, the increased teacher load has resulted in the practice of double sessions which has tended to reduce the amount of individual attention many teachers were previously able to devote to each student. And more extensive demands upon school budgets have led to minimal teacher salary raises, contributing further to the shortage of qualified teachers. This reveals the importance of development of new educational media in order to alleviate some of the stress on the teacher and to keep pace with currently expanding fields of knowledge

Oxidative Chemical Transformations of Sesquiterpene Lactones.

Oxidative chemical transformations of sesquiterpene lactones have been carried out to determine the effect these changes have on the biological activities of these derivatives. Vacuum liquid chromatography was used extensively to isolate the sesquiterpene lactones used for these synthetic transformations. Costunolide and dehydrocostuslactone were isolated from Costus Resinoid (Saussurea lappa) and dihydroparthenolide was isolated from Ambrosia artemisiifolia. The enolate oxidations of sesquiterpene lactones with oxygen and (camphorylsulfonyl)oxaziridine have been investigate. Enolate oxidations of sesquiterpene lactones with oxygen generate low yields of both 11$\alpha$- and 11$\beta$-hydroxylactones. The yields of enolate oxidations with (camphorylsulfonyl)oxaziridine are much improved (over oxygen) and the reaction is stereospecific. This methodology was used to prepare a series of 11-hydroxysesquiterpene lactones of various skeletal types. Two naturally occurring sesquiterpene lactones (11$\beta$,15-dihydroxysaussurea lactone and 15-hydroxydihydrocostunolide) were synthesized from costunolide. These transformations involved the use of enolate oxidations developed previously, allylic oxidations with selenium dioxide, and Cope rearrangements of 1,5-dienes. A hydroperoxy-sesquiterpene lactone (peroxydihydroparthenolide) was synthesized via an ene reaction between an alkene and singlet oxygen. The first biomimetic conversion of a germacrolide to a heliangolide was achieved using tert-butyl hydroperoxide and selenium dioxide supported on silica gel. Other attempted allylic oxidations of a 1,10-epoxygermacrolide with selenium dioxide resulted in isolation of only transannular cyclization products or oxidatively modified cyclization products

Engle, Jesse Samuel

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