It\u27s Never One-Sided

In lieu of an abstract, below is the essay\u27s first paragraph. Every time Gordon exits that dingy little pornography theater, he extinguishes his scorpion-red cigarette with the butt of his left palm. \u27Remember that pain the next time you want to give into sin,\u27 Gordon usually mumbles in an effort to reproach his spontaneous and fleeting immorality. interestingly he feels no guilt when he enters it, but instead relishes in anticipation of the flesh-indulging sin screen. It\u27s like being back in the tenth grade all over again when Gordon and Tommy Baker would sneak into the high school basement to peer through a hole the size of a pen tip, partially blocked by a soap tray, into the girl\u27s shower; the only difference being that Tommy and Gordon never saw but a few callused hammer toes and, if they really put their heads to the dusty floor bottom, a couple of bruised knees

Comparing the Risk Attitudes of U.S. and German Farmers

Risk and Uncertainty,

Skeletal Rigidity of Phylogenetic Trees

Motivated by geometric origami and the straight skeleton construction, we outline a map between spaces of phylogenetic trees and spaces of planar polygons. The limitations of this map is studied through explicit examples, culminating in proving a structural rigidity result.Comment: 17 pages, 12 figure

Structure-Activity Relationships of Retinoids in Developmental Toxicology

The teratogenic potency of retinoid analogs was determined in Syrian hamsters and compared to the teratogenic potency of all-trans-retinoic acid (all-trans.-RA, ED50 = 10.5 mg/kg). A total of 15 analogs having variations in the cyclohexene ring were evaluated following various amounts of single oral doses on day 8 of gestation. Retinoids containing a five- or six-membered ring were as teratogenic as all-tmru.-RA, provided they had sufficient lipophilic substituents on the ring. The same pattern emerged for retinoids that had six-membered aromatic ring substitution for the natural cyclohexene ring of vitamin A. Incorporation of a supplementary aromatic ring in the side-chain adjacent to a gem-dimethyl-hexene ring resulted in an increase in teratogenicity by IS-fold compared to all-trans.-RA. Major modifications of the cyclohexene ring can be made without altering teratogenic activity. The ring need not be six-membered and can have decreased lipophilicity through the incorporation of polar groups compared to all-trans.-RA, but must have sufficient lipophilic substituents to provide the necessary mass for interaction with the retinoid receptor. Incorporation of a supplementary aromatic ring adjacent to a gem-dimethyl-hexene ring facilitated π-electron delocalization and restricts side-chain flexibility , thereby increasing teratogenic potency. The pharmacokinetic disposition of 8 retinoids was investigated. Pregnant hamsters were dosed orally with all-trans-RA, 13-cis-retinoic acid, all-trans.-4- oxoretinoic acid, 9-cis-retinal, all-trans.-retinyl acetate, N-ethyl-all-trans- retinamide, N-ethyl-13-cis-retinamide, and arotinoid. The bioavailability of the retinamides was one-tenth that of the free acid retinoids. The plasma elimination half-life for all-trans-RA was 0.5 h. For 13-cis-retinoic acid and all-trans-4-oxoretinoic acid the elimination half-lives were 4.4 and 5.7 h, respectively. The binding affinity of various retinoids to cellular retinoic acid-binding protein (cRABP) was determined in day-12 hamster fetuses. Fetal supernatants from the 105,000x g fraction were incubated with high specific-activity [3H]-all-trans-RA in the presence of various concentration of unlabeled retinoids with subsequent isolation of cRABP by size-exclusion HPLC. Teratogenic retinoids, or acidic metabolites of teratogenic retinoids bound to cRABP whereas nonteratogenic retinoids failed to bind

Shooting the Shit

In lieu of an abstract, below is the essay\u27s first paragraph. I know I could have her any time that I want and I know that she wants me even more. Don\u27t mistake my certainty for over-confidence or a cocky sort of attitude \u27cause I ain\u27t about all that. Fact is, I can tell just by looking at a girl\u27s eyes whether she want to bed me or not. Anyway, as if I needed to explain myself to you in the first place. You should be so lucky that I tell you anything at all. I mean, this is my life that you\u27re reading about isn\u27t it? I never really could figure out why people sit down with their pen and paper thinking that their words mean something. \u27Cause as soon as idiot knuckle heads like you get a hold of the stuff it\u27s as worthless as Christianity in Ethiopia everyone anticipates this great exchange, when all it ever amounts to is all take and no give. But like I was saying, this girl needs me real bad, right? And she\u27s been sending the eye through this here crowded room all night long. You know, one of those sorry-ass stuffy inner-city houses that have College-Dormers-Living-Off-Campus-For-The-Semester\u27\u27 written all over them. And, as if the requisite dart board and too-cheesy-for-me portable bar with neon lights isn\u27t bad enough they\u27ve seen to it to invite every beer-suckin, titty-twistin, exam-flunking dork on campus. And so I\u27m wondering (don\u27t bother me, okay): Self, would you bother moving off campus and endure extra commutes just so that you could not-quite-afford to drag everyone else off of campus to come to your house? But my self can\u27t answer that question right now because the girl with the moist panties is staring me in the eye again. Well, like I said, she wants my sex something fierce. I almost never have to ask for it. Actually, I don\u27t ever have to. Only sometimes I do it to humor the other person. Can you believe it? She\u27s actually coming over here to me right now. I hate to say it, but I told you ... wait a minute, I don\u27t have to say it because you\u27ve probably read it somewhere before. Anyway I got to go right now to take care of business if you know what I mean, but I\u27ll be back right away

Leveraging Synergy Between Database and Programming Language Courses

Undergraduate courses in database systems and programming languages are frequently taught without much overlap. This paper argues that there is a substantial benefit to emphasizing some areas of commonality, both old and new, between the two subjects. Examples of cross-fertilization that may be used to enhance one of both of the courses include query language design and implementation, object-relational mapping, transactional memory, and various aspects of the recent NoSQL movement

Models of medical malpractice in Jewish law

Medical malpractice is largely a product of the modem era. Consequently, one might suppose that ancient sources have little to add to any meaningful discussion of the topic. Yet, numerous models and precedents directly or indirectly applicable to malpractice surface in the vast body of traditional Jewish literature of the last two millennia. These sources can lend profound insight for the physician - and others - grappling with issues of moral and legal responsibilities related to care of patients and malpractice. This thesis will first catalogue the various types of immunities, and qualifications for those immunities, granted by Jewish law to the physician. These immunities allow the physician to practice while safeguarding the public\u27s best interests. Permission to heal and obligation to heal are immunities that primarily relate to man\u27s responsibility to G-d. Immunity from the Biblical prohibition of wounding another human being represents a dual privilege, as the prohibition of wounding issued from G-d, but wounding directly affects one\u27s fellow human being. Finally, immunity from payment of damages relates to man\u27s responsibility to his fellow man. The thesis will then address several issues in malpractice, such as the burden of proof, types of physician error, and the status of bad outcomes. These issues will be analyzed from the perspective of classical models in Jewish law, which relate both directly and indirectly to malpractice. The contemporary Jewish legal authority must often extrapolate concepts from other areas of the law in order to render decisions relating to uniquely modem issues such as medical malpractice. The goal of this thesis is to foster within the reader an appreciation of the value of traditional Jewish literature in analyzing problems in medical malpractice today