Improved superabsorbent polymers

This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.This work is devoted to the synthesis, characterization and modification of a class of acrylic-based superabsorbent polymers. The techniques of inverse suspension and solution polymerisations were used for synthesis. Each absorbent was mainly characterised by its equilibrium capacity of water absorption and by the rate of absorption. The swelling characteristics of the polymers were evaluated in terms of change in polymerisation variables which include, type and amount of crosslinker, monomer composition, process of polymerisation, temperature, initiator concentration, monomer concentration and particle size of the product. The swelling dependency on salinity was also examined. In some cases, the base polymer was blended with certain polymers in order to upgrade the swelling properties. A swelling model was devised based on a simple viscoelastic model, i. e. Voigt model, to obtain a better understanding of the effect of the above-mentioned variables on the swelling behaviour. Finally, our materials of choice were compared with some commercial analogues and some further comments have been made for continuing the work

Exploring the Potential of Nanotechnology in Pediatric Healthcare: Advances, Challenges, and Future Directions.

The utilization of nanotechnology has brought about notable advancements in the field of pediatric medicine, providing novel approaches for drug delivery, disease diagnosis, and tissue engineering. Nanotechnology involves the manipulation of materials at the nanoscale, resulting in improved drug effectiveness and decreased toxicity. Numerous nanosystems, including nanoparticles, nanocapsules, and nanotubes, have been explored for their therapeutic potential in addressing pediatric diseases such as HIV, leukemia, and neuroblastoma. Nanotechnology has also shown promise in enhancing disease diagnosis accuracy, drug availability, and overcoming the blood-brain barrier obstacle in treating medulloblastoma. It is important to acknowledge that while nanotechnology offers significant opportunities, there are inherent risks and limitations associated with the use of nanoparticles. This review provides a comprehensive summary of the existing literature on nanotechnology in pediatric medicine, highlighting its potential to revolutionize pediatric healthcare while also recognizing the challenges and limitations that need to be addressed

Transformative dynamism in pharmaceutical and biomedical research: Complexity of integration of innovative R & D hubs

Introduction: To be fully functional, pharmaceutical, and biomedical research centers need to be transformed to become innovative research and development (R & D) hubs. Such transformation, however, is a dynamic complex matter. Methods: To establish an innovative R & D hub, a simple and concise manifesto is conceptualized for the nonlinear dynamic transformation towards an innovative research hub to reinforce the transition of the 2nd generation R & D centers. Results: Interdisciplinary research is the most demanded field of research to overcome various multi-sided health issues. To become an innovative R & D hub, pharmaceutical centers must function as a small-scale physical infrastructure to support the inter-communication of scientists and provide specific technological needs to promote the related innovation and entrepreneurship with advanced business plans and prototypes. Given that a success paradigm within an unorderly surrounding setting has already been condemned to fail, the orderly integration of nested systems and groups should be carefully implemented towards a shared vision with formal and tacit agreements among all parties, including academia, industry, and finance team. Conclusion: To achieve a fully functional innovative R & D hub, a "know-how" approach with the systems thinking mindset within all the parties is of paramount necessity. The healthier the order of the whole working system is, the more effective will be the encompassed entitles and players. However, systems should have several checkpoints to enhance clarity and evade discrepancy and divergence. Since the medication is a highly trusted and needed public enterprise, the drug discovery and development paradigm should be practiced at the highest speed with maximum transparency and accountability

Developing a Grounded Theory Model of Effective Factors and Consequences of Gender-Affirming for Transgender People and Those with Undifferentiated Gender in Iran

Background: Transgender people and those who have an undifferentiated gender identity face various personal and social challenges due to their dissatisfaction with the gender role and the desire to behave differently from the gender role. Thus, focusing on this group of people is one of the issues in health and psychology. To this end, the present study aimed to explore more deeply the challenges and problems faced by this group of people.Methods: This qualitative study was conducted based on the grounded theory proposed by Corbin and Strauss on 15 members of social networks and the Association of People with Gender Dissatisfaction. The participants were selected through purposive sampling from among those with undifferentiated gender identities from childhood to adulthood. The data were collected via individual in-depth interviews with the participants. The collected data were analyzed using the systematic grounded theory approach to extract related categories and codes and develop a conceptual model.Results: The analysis of the data revealed 54 themes that were grouped into 9 subcategories and 5 main categories. Gender affirming was extracted as the core phenomenon. The causal factors included the feeling of living in another person’s body and problems in social relationships. Contextual factors were divided into 4 subcategories including family challenges, positive and negative public reactions, peer relationship problems, and economic challenges. The intervening factors were school problems and the role of media. In addition, the consequences were the positive and negative experiences of life in another body. Finally, the extracted strategies were support and individual coping strategies.Conclusion: Social factors and family and school play an important role in aggravating the problems of people with gender dissatisfaction. Focusing on empowering these people can help them adopt effective coping strategies. Besides, given the lack of recognition for people with gender dissatisfaction, raising public awareness of the challenges faced by these people is particularly important

DRUJ instability after distal radius fracture: A comparison between cases with and without ulnar styloid fracture

AbstractBackgroundBecause of the importance of the DRUJ in upper extremity function and the prevalence of distal radius fractures, either with or without ulnar styloid fracture, this study was designed to assess the relationship between ulnar styloid fracture and the incidence of DRUJ instability after treatment of distal radius fractures treated with ORIF (volar plate).Methods112 patients suffering from type two and three distal radius fractures (Fernandez classification), were evaluated. Depending on the presence of ulnar styloid avulsion fracture, patients were divided into two groups: 86 cases with isolated radial fracture and 26 cases with a distal radius fracture accompanied by ulnar styloid fracture. All patients underwent distal radius fracture ORIF. CT scanning was done both immediately after surgery and 3 months post-op. DRUJ stability was examined using the modified radioulnar line method and the incidence of DRUJ instability was compared between the two groups.ResultsImmediate instability was seen in 11 patients. Three of these patients had concomitant ulnar styloid fracture and were excluded for further fixation. Three months later, another 9 cases were diagnosed with DRUJ instability, 2 of whom had concomitant ulnar styloid fracture and the other 7 suffered from isolated distal radius fracture. Chi-square test revealed no significant difference (p < 0.05). There were no cases of delayed union or non-union distal radius fracture.ConclusionOur study demonstrated that untreated stable or minimally displaced ulnar styloid fracture accompanied by distal radius fracture, has no adverse effect on DRUJ stability following ORIF of the radius

The genes expression status of inflammatory determinants following the oral administration of Mannuronic acid in patients with rheumatoid arthritis

Introduction: Rheumatoid arthritis (RA) is a progressive multifactorial inflammatory disorder. According to numerous evidence, pro-inflammatory markers such as TNF-a, IL-6, IL-22, MYD88 and TLR2 play a substantial role in the pathogenesis and persistence of this disease. B-D-Mannuronic acid (M2000) is a new immunosuppressive drug whose therapeutic effects have been approved in several clinical trials and the results of the phase III clinical trial of this drug in RA patients were potent and efficient. Therefore, the present investigation was designed to evaluate its anti-inflammatory effects on the expression of mentioned factors in RA patients. Material and methods: This research was carried out on 12 healthy individuals and 12 patients with RA and M2000 was administered to the patients orally at a dose of 500 mg twice daily for 12 weeks. The peripheral blood mononuclear cells (PBMCs) were collected from the patients before and after treatment with M2000 to investigate the gene expression levels of TNF-a, IL-6, IL-22, MYD88 and TLR2 molecules in them using Real-time PCR. Results: This study data represented a higher gene expression in all target molecules in the RA patients in comparison to the healthy individuals. Furthermore, the outcomes showed that after 12 weeks of therapy with M2000, the gene expression levels of inflammatory factors TNF-a, IL-6, IL-22, MYD88 and TLR2 decreased significantly in treated patients compared to before therapy. The gene expression results were following the clinical and paraclinical assessments. Conclusion: In conclusion, M2000 as a newly approved anti-inflammatory and immunosuppressive drug, can be proposed as a therapeutic agent in RA patients

Automated space/time scaling of streaming task graphs on field-programmable gate arrays

Parallel computing platforms provide good performance for streaming applications within a limited power budget. However, these platforms can be difficult to program. Moreover, when the size of the computing platform target changes, users must manually reallocate resources and parallelism. This thesis provides a framework to retarget applications described by a Streaming Task Graph (STG) for implementation on different platforms, where the framework can automatically scale the solution size to fit available resource or performance targets. First, we explore automated space/time scaling for STGs targeting a pipelined coarse-grained architecture. We produce a tool that analyzes the degrees of parallelism in a general stream application and finds possible bottlenecks. We introduce possible optimization strategies for STGs, and two algorithmic approaches: a classical approach based upon Integer Linear Programming (ILP), and a novel heuristic approach which introduces a new optimization and produces better results (using 30% less area) with a shorter run-time. Second, we explore automated space/time scaling for STGs targeting a fine-grained architecture (Field-Programmable Gate Array (FPGA)). We propose a framework on top of a commercial High-Level Synthesis (HLS) tool which adds the ability to automatically meet a defined area budget or target throughput. Within the framework, we use similar ILP and heuristic approaches. The heuristic automatically achieves over 95% of the target area budget on average while improving throughput over the ILP. It can also meet the same throughput targets as the ILP while saving 19% area. Third, we investigate automated space/time scaling of STGs in a hybrid architecture consisting of a Soft Vector Processor (SVP) and select custom instructions. To achieve higher performance, we investigate using dynamic Partial Reconfiguration (PR) by time-sharing the FPGA resources. The performance results achieve speedups far beyond what a plain SVP can accomplish: an 8-lane SVP achieves a speedup of 5.3 on the Canny-blur application, whereas the PR version is another 3.5 times faster, with a net speedup of 18.5 over the ARM Cortex A9 processor. By increasing the dynamic PR rate beyond what is available today, we also show that a further 5.7 times speedup can be achieved (105.9x speedup versus the Cortex A9).Applied Science, Faculty ofElectrical and Computer Engineering, Department ofGraduat

Swellable Microneedles in Drug Delivery and Diagnostics

This manuscript explores the transformative potential of swellable microneedles (MNs) in drug delivery and diagnostics, addressing critical needs in medical treatment and monitoring. Innovations in hydrogel-integrated MN arrays facilitate controlled drug release, thereby expanding treatment options for chronic diseases and conditions that require precise dosage control. The review covers challenges, such as scalability, patient compliance, and manufacturing processes, as well as achievements in advanced manufacturing, biocompatibility, and versatile applications. Nonetheless, limitations in physiological responsiveness and long-term stability remain, necessitating further research in material innovation and integration with digital technologies. Future directions focus on expanding biomedical applications, material advancements, and regulatory considerations for widespread clinical adoption

Advancements and Applications of Injectable Hydrogel Composites in Biomedical Research and Therapy.

Injectable hydrogels have gained popularity for their controlled release, targeted delivery, and enhanced mechanical properties. They hold promise in cardiac regeneration, joint diseases, postoperative analgesia, and ocular disorder treatment. Hydrogels enriched with nano-hydroxyapatite show potential in bone regeneration, addressing challenges of bone defects, osteoporosis, and tumor-associated regeneration. In wound management and cancer therapy, they enable controlled release, accelerated wound closure, and targeted drug delivery. Injectable hydrogels also find applications in ischemic brain injury, tissue regeneration, cardiovascular diseases, and personalized cancer immunotherapy. This manuscript highlights the versatility and potential of injectable hydrogel nanocomposites in biomedical research. Moreover, it includes a perspective section that explores future prospects, emphasizes interdisciplinary collaboration, and underscores the promising future potential of injectable hydrogel nanocomposites in biomedical research and applications