3 research outputs found
Mechanistic Insights and Kinetic Analysis for the Oxidative Hydroxylation of Arylboronic Acids by Visible Light Photoredox Catalysis: A Metal-Free Alternative
The photocatalytic hydroxylation
of boronic acids with methylene
blue as photosensitizer proceeds with high efficiency. Detailed time-resolved
studies of the relevant rate constants provide a clear mechanistic
understanding of excited-state processes and guided the selection
of the photocatalyst and the optimization of experimental conditions
Metal-Free Photocatalytic Radical Trifluoromethylation Utilizing Methylene Blue and Visible Light Irradiation
The use of organofluorine compounds,
especially those with an incorporated
trifluoromethyl moiety, has increased dramatically in both the pharmaceutical
and agrochemical industry. It has therefore become imperative to develop
a mild and efficient synthetic technique for the inclusion of trifluoromethyl
groups. Herein, we report the first use of methylene blue as a photosensitizer
for the catalytic radical trifluoro- and hydrotrifluoromethylation
of electron-rich heterocycles as well as terminal alkenes and alkynes
under visible light irradiation. These reactions proceed with moderate
to good yields at low catalyst concentrations; short irradiation times;
and most importantly, without the need for potentially toxic transition-metal
catalysts. In this work, considerable emphasis was also placed on
understanding the kinetics of the mechanistically key steps through
the use of laser flash photolysis techniques to more efficiently optimize
the reaction conditions
Photoinduced Carbene Generation from Diazirine Modified Task Specific Phosphonium Salts To Prepare Robust Hydrophobic Coatings
3-Aryl-3-(trifluormethyl)diazirine functionalized highly
fluorinated
phosphonium salts (HFPS) were synthesized, characterized, and utilized
as photoinduced carbene precursors for covalent attachment of the
HFPS onto cotton/paper to impart hydrophobicity to these surfaces.
Irradiation of cotton and paper, as proof of concept substrates, treated
with the diazirine-HFPS leads to robust hydrophobic cotton and paper
surfaces with antiwetting properties, whereas the corresponding control
samples absorb water readily. The contact angles of water were determined
to be 139° and 137° for cotton and paper, respectively.
In contrast, water placed on the untreated or the control samples
(those treated with the diazirine-HFPS but not irradiated) is simply
absorbed into the surface. Additionaly, the chemically grafted hydrophobic
coating showed high durability toward wash cycles and sonication in
organic solvents. Because of the mode of activation to covalently
tether the hydrophobic coating, it is amenable to photopatterning,
which was demonstrated macroscopically