Line and Continuum Variability in Active Galaxies

We compared optical spectroscopic and photometric data for 18 AGN galaxies over 2 to 3 epochs, with time intervals of typically 5 to 10 years. We used the Multi-Object Double Spectrograph (MODS) at the Large Binocular Telescope (LBT) and compared the spectra to data taken from the SDSS database and the literature. We find variations in the forbidden oxygen lines as well as in the hydrogen recombination lines of these sources. For 4 of the sources we find that, within the calibration uncertainties, the variations in continuum and line spectra of the sources are very small. We argue that it is mainly the difference in black hole mass between the samples that is responsible for the different degree of continuum variability. In addition we find that for an otherwise constant accretion rate the total line variability (dominated by the narrow line contributions) reverberates the continuum variability with a dependency $\Delta L_{line} \propto (\Delta L_{cont.})^{\frac{3}{2}}$. Since this dependency is prominently expressed in the narrow line emission it implies that the luminosity dominating part of the narrow line region must be very compact with a size of the order of at least 10 light years. A comparison to literature data shows that these findings describe the variability characteristics of a total of 61 broad and narrow line sources.Comment: 30 pages including the appendix, 18 figures including the appendix. Accepted 2015 September 3. Received 2015 August 24; in original form 2015 July 3 in Monthly Notices of the Royal Astronomical Societ

Sequential star formation in IRAS 06084-0611 (GGD 12-15): From intermediate-mass to high-mass stars

Context. The formation and early evolution of high- and intermediate-mass stars towards the main sequence involves the interplay of stars in a clustered and highly complex environment. To obtain a full census of this interaction, the Formation and Early evolution of Massive Stars (FEMS) collaboration studies a well-selected sample of 10 high-mass star-forming regions. Aims. In this study we examine the stellar content of the high-mass star-forming region centered on IRAS 06084-0611 in the Monoceros R2 cloud. Methods. Using the near-infrared H- and K-band spectra from the VLT/SINFONI instrument on the ESO Very Large Telescope (VLT)and photometric near-infrared NTT/SOFI, 2MASS and Spitzer/IRAC data, we were able to determine the spectral types for the most luminous stars in the cluster. Results. Two very young and reddened massive stars have been detected by SINFONI: a massive Young Stellar Object (YSO) con- sistent with an early-B spectral type and a Herbig Be star. Furthermore, stars of spectral type G and K are detected while still in the Pre-Main Sequence (PMS) phase. We derive additional properties such as temperatures, extinctions, radii and masses. We present a Hertzsprung-Russell diagram and find most objects having intermediate masses between \sim1.5-2.5 M\odot. For these stars we derive a median cluster age of \sim4 Myr. Conclusions. Using Spitzer/IRAC data we confirm earlier studies that the younger class 0/I objects are centrally located while the class II objects are spread out over a larger area, with rough scale size radii of \sim0.5 pc and \sim1.25 pc respectively. Moreover, the presence of a massive YSO, an ultracompact H ii region and highly reddened objects in the center of the cluster suggest a much younger age of < 1 Myr. A possible scenario for this observation would be sequential star formation along the line of sight; from a cluster of intermediate-mass to high-mass stars.Comment: 14 pages, 10 figures, 2 tables. Astronomy and Astrophysic

SUBARU and e-Merlin observations of NGC3718. Diaries of an SMBH recoil?

NGC3718 is a LINER $L1.9$ galaxy, lying at a distance of about $\sim 17.4$ Mpc away from earth and its similarities with NGC5128 often award it the name "northern Centaurus A". We use high angular resolution ($\sim100$ mas) e-Merlin radio and SUBARU NIR ($\sim170$ mas) data, to take a detailed view of the processes taking place in its central region. In order to preserve some objectivity in our interpretation, we combine our results with literature values and findings from previous studies. Our NIR maps suggest, on one hand, that towards the stellar bulge there are no large scale absorption phenomena caused by the apparent dust lane and, on the other, that there is a significant (local) contribution from hot ($\sim1000$ K) dust to the nuclear NIR emission. The position where this takes place appears to be closer to the offset compact radio emission from our e-Merlin $6$ cm map, lying offset by $\sim4.25$ pc from the center of the underlying stellar bulge. The shape of the radio map suggests the presence of one (or possibly two, forming an X-shape) bipolar structure(s) $\sim1$ ($\sim0.6$) arcsec across, which combined with the balance between the gas and the stellar velocity dispersions and the presence of hard X-ray emission, point towards effects expected by AGN feedback. We also argue that NGC3718 has a "core" in its surface brightness profile, despite the fact that it is a gas-rich galaxy and we discuss its mixed photometric and spectroscopic characteristics. The latter combined with the observed spatial and radio offsets, the relative redshift between the broad and the narrow $H{\mathrm{\alpha}}$ line, the limited star formation activity and AGN feedback, strongly imply the existence of an SMBH recoil. Finally, we discuss a possible interpretation, that could naturally incorporate all these findings into one physically consistent picture.Comment: 18 pages, 18 figures, 3 tables, accepted for publications in A&

Plasma Cholesterol Ester Fatty Acids: A New Biochemical Abnormality in Obstructive Jaundice

Changes in fatty acid patterns may explain many of the observed abnormalities found in obstructive jaundice. This study looked at fatty acids in plasma cholesterol esters, in a group of patients with obstructive jaundice and a matched group of controls. Significant abnormalities were demonstrated, most importantly a fall in essential fatty acids, in the jaundiced group. Overall the saturation of this fraction, as assessed by double bond index, rose. The essential fatty acids are important as factors in membrane function and as precursors of eicosanoids. The abnormalities found in this study provide further evidence of the significance of EFA in patients with obstructive jaundice

Peer-review in a world with rational scientists: Toward selection of the average

One of the virtues of peer review is that it provides a self-regulating selection mechanism for scientific work, papers and projects. Peer review as a selection mechanism is hard to evaluate in terms of its efficiency. Serious efforts to understand its strengths and weaknesses have not yet lead to clear answers. In theory peer review works if the involved parties (editors and referees) conform to a set of requirements, such as love for high quality science, objectiveness, and absence of biases, nepotism, friend and clique networks, selfishness, etc. If these requirements are violated, what is the effect on the selection of high quality work? We study this question with a simple agent based model. In particular we are interested in the effects of rational referees, who might not have any incentive to see high quality work other than their own published or promoted. We find that a small fraction of incorrect (selfish or rational) referees can drastically reduce the quality of the published (accepted) scientific standard. We quantify the fraction for which peer review will no longer select better than pure chance. Decline of quality of accepted scientific work is shown as a function of the fraction of rational and unqualified referees. We show how a simple quality-increasing policy of e.g. a journal can lead to a loss in overall scientific quality, and how mutual support-networks of authors and referees deteriorate the system.Comment: 5 pages 4 figure

Nuclear Activity and the Conditions of Star-formation at the Galactic Center

The Galactic Center is the closest galactic nucleus that can be studied with unprecedented angular resolution and sensitivity. We summarize recent basic observational results on Sagittarius A* and the conditions for star formation in the central stellar cluster. We cover results from the radio, infrared, and X-ray domain and include results from simulation as well. From (sub-)mm and near-infrared variability and near-infrared polarization data we find that the SgrA* system (supermassive black hole spin, a potential temporary accretion disk and/or outflow) is well ordered in its geometrical orientation and in its emission process that we assume to reflect the accretion process onto the supermassive black hole (SMBH).Comment: 11 pages, 4 figures, 1 table; published in PoS-SISSA Proceedings of the: Frontier Research in Astrophysics - II, 23-28 May 2016, Mondello (Palermo), Ital

Inhibition of hepatocyte growth factor-induced motility and in vitro invasion of human colon cancer cells by gamma-linolenic acid.

In this study we have determined the effects of the n-6 essential fatty acid gamma-linolenic acid (GLA) on the motility and invasive/metastatic nature of the human colon cancer cell lines HT115, HT29 and HRT18. Cell motility was induced by hepatocyte growth factor/scatter factor (HGF/SF) and measured by both colony scattering and dissociation from carrier beads. Invasiveness was measured in vitro by cellular invasion into extracellular matrix. At concentrations up to 100 microM (which had no effect on cell growth over the duration of the experiments) both cell motility and invasion induced by HGF/SF were markedly reduced by GLA and its lithium salt. The attachment of these cells to the extracellular matrix components (Matrigel and fibronectin) was also inhibited. There were also changes in the cell-surface E-cadherin, but not fibronectin receptor at similar concentrations. It is concluded that n-6 essential fatty acids have the ability to inhibit both motility and invasiveness of human colon cancer cells, perhaps by modifying cell-surface adhesion molecules

Treatment of premenstrual tension with lithium carbonate – A PILOT STUDY

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/66408/1/j.1600-0447.1980.tb00569.x.pd