Effect of vesical overdistention on bladder mucin

Histochemical staining of bladder tissue demonstrates a discrete layer of mucopolysaccharide (mucin) on the surface of human and rabbit bladders. Studies have shown that an intact mucin layer may be important in helping the bladder to resist bacterial infections. This report correlates vesical overdistention with destruction of the mucin layer in the rabbit bladder. These findings suggest that vesical overdistention may predispose to urinary tract infection because of bladder mucin disruption.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/24244/1/0000507.pd