Evolving community response to tourism and change in Rotorua

The aim of this report is to outline how the Rotorua community experiences tourism and tourism development and how they have adapted to it. The objectives are to: give an historical account of the history of the development of tourism in Rotorua; give an account of broader community issues which influence the community's attitudes to tourism development in their town; record the perceptions that residents have of tourism and show how these have changed over time; describe how the host community copes with the type of tourism development that exists in the area; and suggest what factors might be important in influencing residents' perceptions of tourism and their adaptation to it. This report argues that the community in Rotorua is generally very accepting of tourism, and that tourism in the town is well managed due to the proactive role taken by the local Council in relation to tourism development and promotion. Local people see tourism as a source of stability at a time of great change. For local decision-makers, tourism is a means to address the problems of unemployment and poverty which appear to be increasing in the area

Quantum authentication with unitary coding sets

A general class of authentication schemes for arbitrary quantum messages is proposed. The class is based on the use of sets of unitary quantum operations in both transmission and reception, and on appending a quantum tag to the quantum message used in transmission. The previous secret between partners required for any authentication is a classical key. We obtain the minimal requirements on the unitary operations that lead to a probability of failure of the scheme less than one. This failure may be caused by someone performing a unitary operation on the message in the channel between the communicating partners, or by a potential forger impersonating the transmitter.Comment: RevTeX4, 10 page

Hadamard Products of Product Operators and the Design of Gradient-Diffusion Experiments for Simulating Decoherence by NMR Spectroscopy

An extension of the product operator formalism of NMR is introduced, which uses the Hadamard matrix product to describe many simple spin 1/2 relaxation processes. The utility of this formalism is illustrated by deriving NMR gradient-diffusion experiments to simulate several decoherence models of interest in quantum information processing, along with their Lindblad and Kraus representations. Gradient-diffusion experiments are also described for several more complex forms of decoherence, including the well-known collective isotropic model. Finally, it is shown that the Hadamard formalism gives a concise representation of decoherence with arbitrary correlations among the fluctuating fields at the different spins involved, and that this can be applied to both decoherence (T2) as well as nonadiabatic relaxation (T1) processes.Comment: RevTeX, 11 page single-spaced preprint, no figures. Version two has new title, abstract, introduction & conclusions, while the main body of the text remains substantially the sam

Treatment and outcomes of invasive fusariosis: review of 65 cases from the PATH Alliance ® registry

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/109347/1/myc12212.pd

Macrostate Data Clustering

We develop an effective nonhierarchical data clustering method using an analogy to the dynamic coarse graining of a stochastic system. Analyzing the eigensystem of an interitem transition matrix identifies fuzzy clusters corresponding to the metastable macroscopic states (macrostates) of a diffusive system. A "minimum uncertainty criterion" determines the linear transformation from eigenvectors to cluster-defining window functions. Eigenspectrum gap and cluster certainty conditions identify the proper number of clusters. The physically motivated fuzzy representation and associated uncertainty analysis distinguishes macrostate clustering from spectral partitioning methods. Macrostate data clustering solves a variety of test cases that challenge other methods.Comment: keywords: cluster analysis, clustering, pattern recognition, spectral graph theory, dynamic eigenvectors, machine learning, macrostates, classificatio

Altered expression of transmembrane mucins, MUC1 and MUC4, in bladder cancer: pathological implications in diagnosis.

PURPOSE: Radical changes in both expression and glycosylation pattern of transmembrane mucins have been observed in various malignancies. We and others have shown that MUC1 and MUC4, two transmembrane mucins, play a sentinel role in cell signaling events that drive several epithelial malignancies. In the present study, we investigated the expression profile of MUC1 and MUC4 in the non-neoplastic bladder urothelium, in various malignant neoplasms of bladder and in bladder carcinoma cell lines. MATERIAL AND METHODS: Immunohistochemistry was performed on tissue sections from the urinary bladder biopsies, resection samples and tissue microarrays (TMAs) with monoclonal antibodies specific for MUC1 and MUC4. We also investigated their expression in bladder carcinoma cell lines by RT-PCR and immunoblotting. RESULTS: MUC1 is expressed on the apical surface or in umbrella cells of the normal non-neoplastic bladder urothelium. Strong expression of MUC1 was also observed in urothelial carcinoma (UC). MUC1 staining increased from normal urothelium (n = 27, 0.35±0.12) to urothelial carcinoma (UC, n = 323, H-score, 2.4±0.22, p≤0.0001). In contrast to MUC1, MUC4 was expressed in all the layers of non-neoplastic bladder urothelium (n = 14, 2.5±0.28), both in the cell membrane and cytoplasm. In comparison to non-neoplastic urothelium, the loss of MUC4 expression was observed during urothelial carcinoma (n = 211, 0.56±0.06). However, re-expression of MUC4 was observed in a subset of metastatic cases of urothelial carcinoma (mean H-score 0.734±0.9). CONCLUSION: The expression of MUC1 is increased while that of MUC4 decreased in UC compared to the normal non-neoplastic urothelium. Expression of both MUC1 and MUC4, however, are significantly higher in urothelial carcinoma metastatic cases compared to localized UC. These results suggest differential expression of MUC1 and MUC4 during development and progression of bladder carcinoma

Nebulized heparin in burn patients with inhalation trauma : safety and feasibility

Background: Pulmonary hypercoagulopathy is intrinsic to inhalation trauma. Nebulized heparin could theoretically be beneficial in patients with inhalation injury, but current data are conflicting. We aimed to investigate the safety, feasibility, and effectiveness of nebulized heparin. Methods: International multicenter, double-blind, placebo-controlled randomized clinical trial in specialized burn care centers. Adult patients with inhalation trauma received nebulizations of unfractionated heparin (25,000 international unit (IU), 5 mL) or placebo (0.9% NaCl, 5 mL) every four hours for 14 days or until extubation. The primary outcome was the number of ventilator-free days at day 28 post-admission. Here, we report on the secondary outcomes related to safety and feasibility. Results: The study was prematurely stopped after inclusion of 13 patients (heparin N = 7, placebo N = 6) due to low recruitment and high costs associated with the trial medication. Therefore, no analyses on effectiveness were performed. In the heparin group, serious respiratory problems occurred due to saturation of the expiratory filter following nebulizations. In total, 129 out of 427 scheduled nebulizations were withheld in the heparin group (in 3 patients) and 45 out of 299 scheduled nebulizations were withheld in the placebo group (in 2 patients). Blood-stained sputum or expected increased bleeding risks were the most frequent reasons to withhold nebulizations. Conclusion: In this prematurely stopped trial, we encountered important safety and feasibility issues related to frequent heparin nebulizations in burn patients with inhalation trauma. This should be taken into account when heparin nebulizations are considered in these patients