Recent Themes in the History of Africa and the Atlantic World: Historians in Conversation

This book is an engaging collection of eighteen short articles written by fourteen different historians from a range of backgrounds, including both Africanists and non-Africanists. It is the result of two series of exchanges originally printed in the November/December 2004 and the January/February 2006 editions of the journal Historically Speaking, and represents historians in “conversation ” about the Atlantic world. Yerxa, as editor, frames the discussions in terms of the challenges that face historians (and therefore also archaeologists) today, specifically, “constructing narratives that give coherence to a messy and complex past without sacrificing its richness and texture ” (p. 3). It is a short book with plenty to digest, although its ease of reading makes it deceptive in terms of its depth and complexity. The bulk of the text consists of two discussions, one centered around defining Africa and its place in world history, and the other concerning the veracity of Olaudah Equiano’s historical account. The basic format is

Towards representative resilience:the power of culture to foster local resource representation

Community resilience policies continue to grow in popularity as a strategy to prepare for the local impact of forecasted environmental uncertainty, however, criticisms of community resilience discourse remain. This paper takes forward these criticisms, specifically addressing the issue of representative power over key natural resources, using Gaventa’s [Gaventa, J. 2006. “Finding the Spaces for Change: A Power Analysis.” IDS Bulletin 37 (6): 23–33] power cube as a conceptual framework to examine power relations. Our objective is to advance current critical community resilience literature from acknowledging local power relations as a component of any community resilience strategy to situating the devolvement of representative power over key natural resources as a mandatory pre-requisite before any community can be considered "resilient". The paper adopts a case study approach and draws on a grassroots-led resilience project in the Scottish Highlands that utilises traditional land practices and local cultural history to educate people on land sustainability. We explore the potential of the project to construct deeper cultural and historical understandings of local environments and whether projects like these can serve an additional purpose of motivating people to pursue greater influence in land decisions. The analysis reveals emerging links between power, culture and land representation that could foster new forms of local resilience. However, perceptions of systemic barriers such as insecure land tenancies and democratic deficits stymied the potential of this raised motivation. As normative community resilience strategies continue to devolve responsibility over resources without devolving power, a new resilient settlement is required to confront an environmentally uncertain future

Citizen engagement in spatial planning, shaping places together

This paper explores the roles and practices of collective citizen engagement in spatial planning. Drawing on a selection of core articles in planning scholarship, it investigates how citizens (re-)shape urban places by responding to perceived flaws in how spatial planning addresses societal challenges. Formal planning interventions are often spatially and socially selective, ineffective, or even non-existent due to a lack of institutional capacities and resources. Consequently, citizens take on roles that they consider as missing, underperformed or ineffective. The paper shows that this results in a variety of practices complementary to, independent from, or opposing formal planning actors and interventions. Five dilemmas citizens face are identified, highlighting the tensions that surface on exclusion, participation, and governmental responsibilities when citizens claim their role in urban governance

What Future for LEADER as a Catalyst of Social Innovation?

The LEADER Approach was initially designed to promote innovation in European rural areas by sustaining a bottom-up approach to local development. Nowadays the LEADER Approach includes elements that are generally considered to support social innovation. Classical features of the LEADER Approach \u2013 for example, area-based development strategies and cooperation and networking \u2013 are considered catalysts of social innovation as well. By drawing on key elements which support social innovation, the chapter discusses the future role of the LEADER Approach and Local Action Groups, and debates the challenges and potentials of the new rural development policy within emerging social, environmental and economic needs

Author disambiguation using multi-aspect similarity indicators

Key to accurate bibliometric analyses is the ability to correctly link individuals to their corpus of work, with an optimal balance between precision and recall. We have developed an algorithm that does this disambiguation task with a very high recall and precision. The method addresses the issues of discarded records due to null data fields and their resultant effect on recall, precision and F-measure results. We have implemented a dynamic approach to similarity calculations based on all available data fields. We have also included differences in author contribution and age difference between publications, both of which have meaningful effects on overall similarity measurements, resulting in significantly higher recall and precision of returned records. The results are presented from a test dataset of heterogeneous catalysis publications. Results demonstrate significantly high average F-measure scores and substantial improvements on previous and stand-alone techniques

Comprehensive evaluation of methods to assess overall and cell-specific immune infiltrates in breast cancer

Background: Breast cancer (BC) immune infiltrates play a critical role in tumor progression and response to treatment. Besides stromal tumor infiltrating lymphocytes (sTILs) which have recently reached level 1B evidence as a prognostic marker in triple negative BC, a plethora of methods to assess immune infiltration exists, and it is unclear how these compare to each other and if they can be used interchangeably. Methods: Two experienced pathologists scored sTIL, intra-tumoral TIL (itTIL), and 6 immune cell types (CD3+, CD4+, CD8+, CD20+, CD68+, FOXP3+) in the International Cancer Genomics Consortium breast cancer cohort using hematoxylin and eosin-stained (n = 243) and immunohistochemistry-stained tissue microarrays (n = 254) and whole slides (n = 82). The same traits were evaluated using transcriptomic- and methylomic-based deconvolution methods or signatures. Results: The concordance correlation coefficient (CCC) between pathologists for sTIL was very good (0.84) and for cell-specific immune infiltrates slightly lower (0.63-0.66). Comparison between tissue microarray and whole slide pathology scores revealed systematically higher values in whole slides (ratio 2.60-5.98). The Spearman correlations between microscopic sTIL and transcriptomic- or methylomic-based assessment of immune infilt

Predicting clinical benefit from everolimus in patients with advanced solid tumors, the CPCT-03 study

Background: In this study, our aim was to identify molecular aberrations predictive for response to everolimus, an mTOR inhibitor, regardless of tumor type. Methods: To generate hypotheses about potential markers for sensitivity to mTOR inhibition, drug sensitivity and genomic profiles of 835 cell lines were analyzed. Subsequently, a multicenter study was conducted. Patients with advanced solid tumors lacking standard of care treatment options were included and underwent a pre-treatment tumor biopsy to enable DNA sequencing of 1,977 genes, derive copy number profiles and determine activation status of pS6 and pERK. Treatment benefit was determined according to TTP ratio and RECIST. We tested for associations between treatment benefit and single molecular aberrations, clusters of aberrations and pathway perturbation. Results: Cell line screens indicated several genes, such as PTEN (P = 0.016; Wald test), to be associated with sensitivity to mTOR inhibition. Subsequently 73 patients were included, of which 59 started treatment with everolimus. Response and molecular data were available from 43 patients. PTEN aberrations, i.e. copy number loss or mutation, were associated with treatment benefit (P = 0.046; Fisher's exact test). Conclusion: Loss-of-function aberrations in PTEN potentially represent a tumor type agnostic biomarker for benefit from everolimus and warrants further confirmation in subsequent studies

Relational knowledge leadership and local economic development

This paper concerns the role of spatial leadership in the development of the knowledge-based economy. It is argued within academic and practitioner circles that leadership of knowledge networks requires a particular non-hierarchical style that is required to establish an ambience conducive to networking and knowledge sharing across boundaries. In this paper, we explore this hypothesis at both theoretical and empirical levels. Theoretically, we propose a conceptualization of relational knowledge leadership, which is ‘nomadic’ in its capacity to travel across multiple scales and cross sectoral, thematic and geographical boundaries. We have operationalized this type of relational knowledge leadership along four key features, derived from literatures on regional learning, organizational leadership and place leadership. Two empirical case studies are then presented, one from Birmingham in the UK and one from Eindhoven in the Netherlands, exploring how these features are expressed on the sub-national level. Also conclusions are drawn regarding the status of relational knowledge leadership. It is argued that the concept of relational knowledge leadership as viewed through our analytical lens does accord with the experience of leadership in the two cases presented. The cases also show that this style of leadership is confronted with three types of tensions that play through knowledge networking. Furthermore, it is argued that the cases exhibit this style of leadership to different degrees, reflecting their different cultural and political context