MUC4 and MUC1 expression in adenocarcinoma of the stomach correlates with vessel invasion and lymph node metastasis: an immunohistochemical study of early gastric cancer.

We have previously reported that MUC4 expression is a poor prognostic factor in various carcinomas. Our previous study also showed that MUC1 expression in gastric cancers, including the early and advanced stages is a poor prognostic factor. In the present study, the expression profiles of MUC4 and MUC1 were examined by immunohistochemistry (IHC) using two anti-MUC4 monoclonal antibodies (MAbs), 8G7 and 1G8, and anti-MUC1 MAb DF3 in 104 gastrectomy specimens of early gastric adenocarcinoma with submucosal invasion (pT1b2), including 197 histological subtype lesions. Before the IHC study of the human specimens, we evaluated the specificity of the two MAbs by Western blotting and IHC of two MUC4 mRNA expressing gastric cancer cell lines. MAb 8G7 reacted clearly, whereas MAb 1G8 did not show any reactivity, in either Western blotting or IHC. In the IHC of the gastric cancers, the expression rates of MUC4/8G7 detected by MAb 8G7, MUC4/1G8 detected by MAb 1G8 and MUC1/DF3 detected by MAb DF3 in well differentiated types (70%, 38/54; 67%, 36/54; 52%, 28/54) were significantly higher than those in poorly differentiated types (18%, 10/55; 36%, 20/55; 13%, 7/55) (

"Gtool5": a Fortran90 library of input/output interfaces for self-descriptive multi-dimensional numerical data

A Fortran90 input/output library, "gtool5", is developed for use with numerical simulation models in the fields of Earth and planetary sciences. The use of this library will simplify implementation of input/output operations into program code in a consolidated form independent of the size and complexity of the software and data. The library also enables simple specification of the metadata needed for post-processing and visualization of the data. These aspects improve the readability of simulation code, which facilitates the simultaneous performance of multiple numerical experiments with different software and efficiency in examining and comparing the numerical results. The library is expected to provide a common software platform to reinforce research on, for instance, the atmosphere and ocean, where a close combination of multiple simulation models with a wide variety of complexity of physics implementations from massive climate models to simple geophysical fluid dynamics models is required

AKATSUKI-IR2 reveals unexpected opacity disruption affecting Venus's lower clouds every 9 days

The images of AKATSUKI acquired with the camera IR2 at 1.74-2.3 µm report the discovery of an equatorial disruption or “front” in the opacity of the lower clouds of Venus at 50 km between 30ºN¿30ºS. This feature appears on the night every 9 terrestrial days during more than 8 months, and introduces a dramatic and abrupt increase of the cloud opacity and reducing the thermal radiance in a factor of about 1:2 from its brightest to the darkest side.Peer ReviewedPostprint (published version

Primary myoepithelial carcinoma of the lung: a rare entity treated with parenchymal sparing resection

Primary lung myoepithelial carcinomas are rare neoplasms arising from the salivary glands of the respiratory epithelium. Given the rare occurrences and reports of these tumors, appropriate recommendations for resection are difficult to formulate. Although classified as low-grade neoplasms, these tumors have a significant rate of recurrence and distant metastasis