コリニアホログラフィー

学位の種別: 論文博士審査委員会委員 : （主査）東京大学教授 志村 努, 東京大学特任教授 三尾 典克, 東京大学准教授 蘆原 聡, 東京大学教授 高橋 哲, 東京工業大学教授 山口 雅浩University of Tokyo(東京大学

Physiological variation among Tricholoma matsutake isolates generated from basidiospores obtained from one basidioma

ArticleMycoscience. 60(2): 102-109. (2019)journal articl

Sibling spore isolates of Tricholoma matsutake vary significantly in their ectomycorrhizal colonization abilities on pine hosts in vitro and form multiple intimate associations in single ectomycorrhizal roots

ArticleFungal Ecology. 43: 100874. (2020)journal articl

Lensless complex amplitude demodulation based on deep learning in holographic data storage

To increase the storage capacity in holographic data storage (HDS), the information to be stored is encoded into a complex amplitude. Fast and accurate retrieval of amplitude and phase from the reconstructed beam is necessary during data readout in HDS. In this study, we proposed a complex amplitude demodulation method based on deep learning from a single-shot diffraction intensity image and verified it by a non-interferometric lensless experiment demodulating four-level amplitude and four-level phase. By analyzing the correlation between the diffraction intensity features and the amplitude and phase encoding data pages, the inverse problem was decomposed into two backward operators denoted by two convolutional neural networks (CNNs) to demodulate amplitude and phase respectively. The experimental system is simple, stable, and robust, and it only needs a single diffraction image to realize the direct demodulation of both amplitude and phase. To our investigation, this is the first time in HDS that multilevel complex amplitude demodulation is achieved experimentally from one diffraction intensity image without iterations

Therapeutic benefits of factors derived from stem cells from human exfoliated deciduous teeth for radiation-induced mouse xerostomia

Radiation therapy for head and neck cancers is frequently associated with adverse effects on the surrounding normal tissue. Irreversible damage to radiation-sensitive acinar cells in the salivary gland (SG) causes severe radiation-induced xerostomia (RIX). Currently, there are no effective drugs for treating RIX. We investigated the efficacy of treatment with conditioned medium derived from stem cells from human exfoliated deciduous teeth (SHED-CM) in a mouse RIX model. Intravenous administration of SHED-CM, but not fibroblast-CM (Fibro-CM), prevented radiation-induced cutaneous ulcer formation (p < 0.0001) and maintained SG function (p < 0.0001). SHED-CM treatment enhanced the expression of multiple antioxidant genes in mouse RIX and human acinar cells and strongly suppressed radiation-induced oxidative stress. The therapeutic effects of SHED-CM were abolished by the superoxide dismutase inhibitor diethyldithiocarbamate (p < 0.0001). Notably, quantitative liquid chromatography-tandem mass spectrometry shotgun proteomics of SHED-CM and Fibro-CM identified eight proteins activating the endogenous antioxidant system, which were more abundant in SHED-CM than in Fibro-CM (p < 0.0001). Neutralizing antibodies against those activators reduced antioxidant activity of SHED-CM (anti-PDGF-D; p = 0.0001, anti-HGF; p = 0.003). Our results suggest that SHED-CM may provide substantial therapeutic benefits for RIX primarily through the activation of multiple antioxidant enzyme genes in the target tissue