Evaluation of water film by reynolds' equation in deep drawing using high-pressured water jet

The authors had proposed a deep drawing method using high-pressured jet waters as lubricant. This method aimed to suppress the usage of oil or other chemical lubricants, which might require some additional processes for lubricant removal and become a nuisance in environment. The conditions had been determined through trial and error approach without knowing water behaviors as lubricant. As a result, some scars and dimples were observed on the surface of deformed cup. In the present paper, a numerical model was composed for the evaluation of the water behaviors as lubricant. Darcy-Weisbach equation was used for evaluation of pressure drop between nozzle exit and pump, while Reynolds' equation was used for the thin film of fluid between the die and blank. The data of blank deformation in FEM was considered for the determination of the thickness distribution of the fluid film. The characteristics of the water were evaluated by the composed numerical method, and the results were used for examination of lubrication characteristics in experiments

Measurement of an Efimov trimer binding energy in a three-component mixture of 6Li

The binding energy of an Efimov trimer state was precisely determined via radio-frequency association. It is found that the measurement results significantly shift with temperature, but that the shift can be made negligible at the lowest temperature in our experiment. The obtained trimer binding energy reveals a significant deviation from the nonuniversal theory prediction based on a three-body parameter with a monotonic energy dependence.Comment: 4 pages, 4 figure

Non-universal Efimov Atom-Dimer Resonances in a Three-Component Mixture of 6Li

We observed an enhanced atom-dimer relaxation due to the existence of Efimov states in a three-component mixture of 6Li atoms. We measured the magnetic-field dependence of the atom-dimer loss coefficient in the mixture of atoms in state |1> and dimers formed in states |2> and |3>, and found two peaks corresponding to the degeneracy points of the |23> dimer energy level and energy levels of Efimov trimers. We found that the locations of these peaks disagree with universal theory predictions, in a way that cannot be explained by non-universal two-body properties. We constructed theoretical models that characterize the non-universal three-body physics of three-component 6Li atoms in the low energy domain.Comment: 5 pages, 3 figure

Critical Temperature and Condensate Fraction of a Fermion Pair Condensate

We report on measurements of the critical temperature and the temperature dependence of the condensate fraction for a fermion pair condensate of 6Li atoms. The Bragg spectroscopy is employed to determine the critical temperature and the condensate fraction after a fast magnetic field ramp to the molecular side of the Feshbach resonance. Our measurements reveal the level-off of the critical temperature and the limiting behavior of condensate fraction near the unitarity limit

Up-regulation of ICAM-1 expression on human dermal fibroblasts by IFN β in the presence of TNF-α

AbstractUnstimulated human fibroblasts show low or undetectable ICAM-1 expression. Interferon-beta (IFN-β) at concentrations of 10,100, and 1000 IU/ml in the presence of tumor necrosis factor-alpha (TNF-α) significantly increased the ICAM-I expression of fibroblasts in a dose-dependent manner. Treatment with IFN-β alone, however, did not up-regulate the ICAM-1 expression. Furthermore the attachment of peripheral blood mononuclear cells (PBMCs) to cytokine-treated fibroblasts was increased. This augmented attachment was partly inhibited by anti-ICAM-1 antibody. These results suggest that IFN-β and TNF-α may cooperatively modulate the attachment of PBMCs in the dermis

Purification and In Vitro Growth of Human Epidermal Basal Keratinocytes Using a Monoclonal Antibody

We have made a new monoclonal antibody, EL-2, and used it with an immunorosetting procedure combined with Ficoll-Hypaque gradient centrifugation to purify and culture basal keratinocytes. Immunofluorescence of cell suspensions and immunoperoxidase staining of tissue sections demonstrate that EL-2 reacts with malignant cell lines, activated lymphocytes and monocytes, and basal keratinocytes. Sequential immunoprecipitation studies demonstrate that monoclonal antibodies EL-2 and 4F2 detect the same membrane protein. However, we have extended previous studies by making the new observation that both EL-2 and 4F2 react with cultured melanocytes. Basal keratinocytes were purified from single-cell epidermal suspensions by incubation with EL-2 followed by rosetting with rabbit antimouse IgG antibodies covalently linked to bovine red blood cells. Rosetting (basal) keratinocytes were separated from EL-2 negative cells by Ficoll gradient centrifugation. We obtained basal keratinocyte populations of >90% purity as assessed by reactivity with EL-2 and another basal keratinocyte-specific monoclonal antibody, HCl. Langerhans cell, fibroblast, and melanocyte contamination was negligible. Cultures of basal keratinocytes were enriched in EL-2-reactive cells throughout the entire 19 days of culture studied. EL-2 is being used to characterize disorders of keratinocyte proliferation; EL-2 reacted with both squamous and basal cell carcinomas. EL-2 stained only the basal layer of lesional skin from patients with psoriasis, pityriasis rubra pilaris, and Darier's disease. Purification of basal keratinocytes will be important in biochemical and functional studies of normal skin and in establishing long-term keratinocyte lines from normal cells

Group cognitive behavioural therapy (GCBT) versus treatment as usual (TAU) in the treatment of irritable bowel syndrome (IBS): A study protocol for a randomized controlled trial

Background: Irritable bowel syndrome (IBS) is a common disease that affects the quality of life (QOL) and social functioning of sufferers. Visceral anxiety is currently considered a key factor in the onset and exacerbation of IBS, and cognitive-behavioural therapy (CBT) targeting visceral anxiety is thought to be effective. However, access to CBT is limited due to the lack of trained therapists, the substantial time required for therapy and the associated costs. Group CBT (GCBT) may solve some of these problems. We have therefore planned this trial to examine the efficacy of GCBT for IBS. Methods: The trial is a two-armed, parallel group, open label, stratified block randomized superiority trial. The study group will consist of 112 participants (aged 18–75 years) with IBS (Rome-III or IV criteria). Participants will be randomly allocated 1:1 to (i) the intervention group: ten-week GCBT plus treatment as usual (TAU) or (ii) the control group: waiting list (WL) plus TAU. The co-primary outcomes are the change in IBS severity or disease-specific quality of life from baseline to week 13 which is 1 month after the end of treatment. The efficacy of GCBT for IBS will be examined through mixed-effects repeated-measures analysis. Discussion: GCBT, if found effective, can address the issues of the shortage of therapists as well as the time required and the costs associated with individual CBT. Clinically, the findings will help make effective CBT programmes accessible to a large number of distressed IBS patients at lower costs. Theoretically, the results will clarify the relationship between IBS and psychological stress and will help elucidate the underlying mechanisms of IBS. Trial registration: UMIN, CTR-UMIN000031710. Registered on March 13, 2018

A Case of Multicentric Castleman's Disease Having Lung Lesion Successfully Treated with Humanized Anti-interleukin-6 Receptor Antibody, Tocilizumab

This report presents the case of a patient demonstrating multicentric Castleman's disease (MCD) with a lung lesion that was successfully treated with an anti-interleukin-6 receptor antibody, tocilizumab in combination with corticosteroid and tacrolimus. A 43-yr-old female with abnormal shadows on a chest X-ray was referred to the hospital for further examination. She was diagnosed as having MCD based on the characteristic pathology of inguinal lymph node, lung lesions, laboratory data, and undifferentiated arthritis. Corticosteroid and rituximab therapy did not fully ameliorate the symptoms; thus, the therapeutic regimen was changed to include tocilizumab, oral corticosteroid and tacrolimus. This regimen resulted in clinical remission and the dose of tocilizumab and corticosteroid could be tapered. Tocilizumab in combination with corticosteroid and tacrolimus may therefore be a beneficial treatment regimen for lung lesions associated with MCD