神経組織中のP物質とその関連ポリペプチドに関する研究

京都大学0048新制・課程博士医学博士医博第322号新制||医||137(附属図書館)1696京都大学大学院医学研究科生理系専攻(主査)教授 井上 章, 教授 早石 修, 教授 荒木 辰之助学位規則第5条第1項該当Kyoto UniversityDA

第8回麻布大学学術展示「願えば叶う：増井光子展」の記録

Dr. Mitsuko Masui, a great veterinarian and an influential zoo leader who graduated from AzabuUniversity, passed away in July, 2010. She leaves behind many accomplishments, the fruits of her activities at zoological gardens. A memorial service was held at the campus festival in 2010 by the alumni association of Azabu University. In August, 2011, a collection of memorabilia and documents of Dr. Masui were donated to Azabu University. Following receipt of these, a memorial exhibition was held. The exhibition was composed of five corners. Corner 1 displayed Dr. Masui’s pre-Azabu University period. Corner 2 showed items related to her studies at Azabu University. Corner 3 exhibited items connected with Dr. Masui’s tenure at Ueno Zoo, where she began her career as a zoo veterinarian. Corner 4 exhibited items connected with her work at other zoos. She became a well-renowned zoologist and worked as the curator of several zoos. Corner 5 exhibited a part of her collections and explained what she wished. Besides the exhibition, we published a publication in her memory bearing the same title

The Maternal-Effect Gene cellular island Encodes Aurora B Kinase and Is Essential for Furrow Formation in the Early Zebrafish Embryo

Females homozygous for a mutation in cellular island (cei) produce embryos with defects in cytokinesis during early development. Analysis of the cytoskeletal events associated with furrow formation reveal that these defects include a general delay in furrow initiation as well as a complete failure to form furrow-associated structures in distal regions of the blastodisc. A linkage mapping-based candidate gene approach, including transgenic rescue, shows that cei encodes the zebrafish Aurora B kinase homologue. Genetic complementation analysis between the cei mutation and aurB zygotic lethal mutations corroborate gene assignment and reveal a complex nature of the maternal-effect cei allele, which appears to preferentially affect a function important for cytokinesis in the early blastomeres. Surprisingly, in cei mutant embryos a short yet otherwise normal furrow forms in the center of the blastodisc. Furrow formation is absent throughout the width of the blastodisc in cei mutant embryos additionally mutant for futile cycle, which lack a spindle apparatus, showing that the residual furrow signal present in cei mutants is derived from the mitotic spindle. Our analysis suggests that partially redundant signals derived from the spindle and astral apparatus mediate furrow formation in medial and distal regions of the early embryonic blastomeres, respectively, possibly as a spatial specialization to achieve furrow formation in these large cells. In addition, our data also suggest a role for Cei/AurB function in the reorganization of the furrow-associated microtubules in both early cleavage- and somite-stage embryos. In accordance with the requirement for cei/aurB in furrow induction in the early cleavage embryo, germ plasm recruitment to the forming furrow is also affected in embryos lacking normal cei/aurB function