25 research outputs found
Menopause and age-related bone loss
This chapter focuses on two major factors that compromise bone strength in women: the occurrence of menopause and the effects of advancing age. Bone remodeling is balanced during young adulthood with equal volumes of bone resorbed and formed. The effect of bone remodeling partly depends upon the surface area/bone matrix volume configuration of the skeleton. Age‐related bone loss is the result of a reduction in the volume of bone formed by each BMU. The mechanisms responsible for this reduction in bone formation are not understood but may involve a reduction in osteoblast numbers, their work capacity, or life span. Menopause‐related bone loss is a result of four distinct mechanisms: a decline in the net amount of bone deposited by each BMU; a transitory increase in the volume of bone resorbed by each BMU; an increase in the rate of bone remodeling; and a reduction in periosteal apposition associated with intracortical, endocortical, and trabecular bone loss
Cemented versus uncemented hemiarthroplasty of the hip in patients with a femoral neck fracture: a comparison of two modern stem design implants
The relationship between osteoarthritis of the hands, bone mineral density, and osteoporotic fractures in elderly women
Simulated increased soft tissue thickness artefactually decreases trabecular bone score: a phantom study
Analysis of new bone, cartilage, and fibrosis tissue in healing murine allografts using whole slide imaging and a new automated histomorphometric algorithm
Evaluating spine micro-architectural texture (via TBS) discriminates major osteoporotic fractures from controls both as well as and independent of site matched BMD: the Eastern European TBS study
Comparing Bone Microarchitecture by Trabecular Bone Score (TBS) in Caucasian American Women with and Without Osteoporotic Fractures
Generation and validation of a normative, age-specific reference curve for lumbar spine trabecular bone score (TBS) in French women.
Age-related changes in lumbar vertebral microarchitecture are evaluated, as assessed by trabecular bone score (TBS), in a cohort of 5,942 French women. The magnitude of TBS decline between 45 and 85 years of age is piecewise linear in the spine and averaged 14.5 %. TBS decline rate increases after 65 years by 50 %.
INTRODUCTION: This study aimed to evaluate age-related changes in lumbar vertebral microarchitecture, as assessed by TBS, in a cohort of French women aged 45-85 years.
METHODS: An all-comers cohort of French Caucasian women was selected from two clinical centers. Data obtained from these centers were cross-calibrated for TBS and bone mineral density (BMD). BMD and TBS were evaluated at L1-L4 and for all lumbar vertebrae combined using GE-Lunar Prodigy densitometer images. Weight, height, and body mass index (BMI) also were determined. To validate our all-comers cohort, the BMD normative data of our cohort and French Prodigy data were compared.
RESULTS: A cohort of 5,942 French women aged 45 to 85 years was created. Dual-energy X-ray absorptiometry normative data obtained for BMD from this cohort were not significantly different from French prodigy normative data (p = 0.15). TBS values at L1-L4 were poorly correlated with BMI (r = -0.17) and weight (r = -0.14) and not correlated with height. TBS values obtained for all lumbar vertebra combined (L1, L2, L3, L4) decreased with age. The magnitude of TBS decline at L1-L4 between 45 and 85 years of age was piecewise linear in the spine and averaged 14.5 %, but this rate increased after 65 years by 50 %. Similar results were obtained for other region of interest in the lumbar spine. As opposed to BMD, TBS was not affected by spinal osteoarthrosis.
CONCLUSION: The age-specific reference curve for TBS generated here could therefore be used to help clinicians to improve osteoporosis patient management and to monitor microarchitectural changes related to treatment or other diseases in routine clinical practice