Design and implementation of an electro-optical backplane with pluggable in-plane connectors

The design, implementation and characterisation of an electro-optical backplane and an active pluggable in-plane optical connector technology is presented. The connection architecture adopted allows line cards to be mated to and unmated from a passive electro-optical backplane with embedded polymeric waveguides. The active connectors incorporate a photonics interface operating at 850 nm and a mechanism to passively align the interface to the optical waveguides embedded in the backplane. A demonstration platform has been constructed to assess the viability of embedded electro-optical backplane technology in dense data storage systems. The demonstration platform includes four switch cards, which connect both optically and electronically to the electro-optical backplane in a chassis. These switch cards are controlled by a single board computer across a Compact PCI bus on the backplane. The electrooptical backplane is comprised of copper layers for power and low speed bus communication and one polymeric optical layer, wherein waveguides have been patterned by a direct laser writing scheme. The optical waveguide design includes densely arrayed multimode waveguides with a centre to centre pitch of 250μm between adjacent channels, multiple cascaded waveguide bends, non-orthogonal crossovers and in-plane connector interfaces. In addition, a novel passive alignment method has been employed to simplify high precision assembly of the optical receptacles on the backplane. The in-plane connector interface is based on a two lens free space coupling solution, which reduces susceptibility to contamination. Successful transfer of 10.3 Gb/s data along multiple waveguides in the electro-optical backplane has been demonstrated and characterised

Cosmic ray feedback in the FIRE simulations: constraining cosmic ray propagation with GeV gamma ray emission

We present the implementation and the first results of cosmic ray (CR) feedback in the Feedback In Realistic Environments (FIRE) simulations. We investigate CR feedback in non-cosmological simulations of dwarf, sub-$L\star$ starburst, and $L\star$ galaxies with different propagation models, including advection, isotropic and anisotropic diffusion, and streaming along field lines with different transport coefficients. We simulate CR diffusion and streaming simultaneously in galaxies with high resolution, using a two moment method. We forward-model and compare to observations of $\gamma$-ray emission from nearby and starburst galaxies. We reproduce the $\gamma$-ray observations of dwarf and $L\star$ galaxies with constant isotropic diffusion coefficient $\kappa \sim 3\times 10^{29}\,{\rm cm^{2}\,s^{-1}}$. Advection-only and streaming-only models produce order-of-magnitude too large $\gamma$-ray luminosities in dwarf and $L\star$ galaxies. We show that in models that match the $\gamma$-ray observations, most CRs escape low-gas-density galaxies (e.g.\ dwarfs) before significant collisional losses, while starburst galaxies are CR proton calorimeters. While adiabatic losses can be significant, they occur only after CRs escape galaxies, so they are only of secondary importance for $\gamma$-ray emissivities. Models where CRs are ``trapped'' in the star-forming disk have lower star formation efficiency, but these models are ruled out by $\gamma$-ray observations. For models with constant $\kappa$ that match the $\gamma$-ray observations, CRs form extended halos with scale heights of several kpc to several tens of kpc.Comment: 31 pages, 26 figures, accepted for publication in MNRA

The origin of ultra diffuse galaxies: stellar feedback and quenching

We test if the cosmological zoom-in simulations of isolated galaxies from the FIRE project reproduce the properties of ultra diffuse galaxies. We show that stellar feedback-generated outflows that dynamically heat galactic stars, together with a passively aging stellar population after imposed quenching (from e.g. infall into a galaxy cluster), naturally reproduce the observed population of red UDGs, without the need for high spin halos or dynamical influence from their host cluster. We reproduce the range of surface brightness, radius and absolute magnitude of the observed z=0 red UDGs by quenching simulated galaxies at a range of different times. They represent a mostly uniform population of dark matter-dominated galaxies with M_star ~1e8 Msun, low metallicity and a broad range of ages. The most massive simulated UDGs require earliest quenching and are therefore the oldest. Our simulations provide a good match to the central enclosed masses and the velocity dispersions of the observed UDGs (20-50 km/s). The enclosed masses of the simulated UDGs remain largely fixed across a broad range of quenching times because the central regions of their dark matter halos complete their growth early. A typical UDG forms in a dwarf halo mass range of Mh~4e10-1e11 Msun. The most massive red UDG in our sample requires quenching at z~3 when its halo reached Mh ~ 1e11 Msun. If it, instead, continues growing in the field, by z=0 its halo mass reaches > 5e11 Msun, comparable to the halo of an L* galaxy. If our simulated dwarfs are not quenched, they evolve into bluer low-surface brightness galaxies with mass-to-light ratios similar to observed field dwarfs. While our simulation sample covers a limited range of formation histories and halo masses, we predict that UDG is a common, and perhaps even dominant, galaxy type around Ms~1e8 Msun, both in the field and in clusters.Comment: 20 pages, 13 figures; match the MNRAS accepted versio

Breathing FIRE: How Stellar Feedback Drives Radial Migration, Rapid Size Fluctuations, and Population Gradients in Low-Mass Galaxies

We examine the effects of stellar feedback and bursty star formation on low-mass galaxies ($M_{\rm star}=2\times10^6-5\times10^{10}{\rm M_{\odot}}$) using the FIRE (Feedback in Realistic Environments) simulations. While previous studies emphasized the impact of feedback on dark matter profiles, we investigate the impact on the stellar component: kinematics, radial migration, size evolution, and population gradients. Feedback-driven outflows/inflows drive significant radial stellar migration over both short and long timescales via two processes: (1) outflowing/infalling gas can remain star-forming, producing young stars that migrate $\sim1{\rm\,kpc}$ within their first $100 {\rm\,Myr}$, and (2) gas outflows/inflows drive strong fluctuations in the global potential, transferring energy to all stars. These processes produce several dramatic effects. First, galaxies' effective radii can fluctuate by factors of $>2$ over $\sim200 {\rm\,Myr}$, and these rapid size fluctuations can account for much of the observed scatter in radius at fixed $M_{\rm star}.$ Second, the cumulative effects of many outflow/infall episodes steadily heat stellar orbits, causing old stars to migrate outward most strongly. This age-dependent radial migration mixes---and even inverts---intrinsic age and metallicity gradients. Thus, the galactic-archaeology approach of calculating radial star-formation histories from stellar populations at $z=0$ can be severely biased. These effects are strongest at $M_{\rm star}\approx10^{7-9.6}{\rm M_{\odot}}$, the same regime where feedback most efficiently cores galaxies. Thus, detailed measurements of stellar kinematics in low-mass galaxies can strongly constrain feedback models and test baryonic solutions to small-scale problems in $\Lambda$CDM.Comment: Accepted to ApJ (820, 131) with minor revisions from v1. Figure 4 now includes dark matter. Main results in Figures 7 and 1

Repetitive Segmental Structure of the Transducin β Subunit: Homology with the CDC4 Gene and Identification of Related mRNAs

Retinal transducin, a guanine nucleotide regulatory protein (referred to as a G protein) that activates a cGMP phosphodiesterase in photoreceptor cells, is comprised of three subunits. We have identified and analyzed cDNA clones of the bovine transducin β subunit that may be highly conserved or identical to that in other G proteins. From the cDNA nucleotide sequence of the entire coding region, the primary structure of a 340-amino acid protein was deduced. The encoded β subunit has a Mr of 37,375 and is comprised of repetitive homologous segments arranged in tandem. Furthermore, significant homology in primary structure and segmental sequence exists between the β subunit and the yeast CDC4 gene product. The Mr 37,375 β subunit polypeptide is encoded by a 2.9-kilobase (kb) mRNA. However, there exists in retina other β-related mRNAs that are divergent from the 2.9-kb mRNA on the basis of oligonucleotide and primer-extended probe hybridizations. All mammalian tissues and clonal cell lines that have been examined contain at least two β-related mRNAs, usually 1.8 and 2.9 kb in length. These results suggest that the mRNAs are the processed products of a small number of closely related genes or of a single highly complex β gene

On the deuterium abundance and the importance of stellar mass loss in the interstellar and intergalactic medium

We quantify the gas-phase abundance of deuterium and fractional contribution of stellar mass loss to the gas in cosmological zoom-in simulations from the Feedback In Realistic Environments project. At low metallicity, our simulations confirm that the deuterium abundance is very close to the primordial value. The chemical evolution of the deuterium abundance that we derive here agrees quantitatively with analytical chemical evolution models. We furthermore find that the relation between the deuterium and oxygen abundance exhibits very little scatter. We compare our simulations to existing high-redshift observations in order to determine a primordial deuterium fraction of 2.549 +/- 0.033 x 10^-5 and stress that future observations at higher metallicity can also be used to constrain this value. At fixed metallicity, the deuterium fraction decreases slightly with decreasing redshift, due to the increased importance of mass loss from intermediate-mass stars. We find that the evolution of the average deuterium fraction in a galaxy correlates with its star formation history. Our simulations are consistent with observations of the Milky Way's interstellar medium: the deuterium fraction at the solar circle is 85-92 per cent of the primordial deuterium fraction. We use our simulations to make predictions for future observations. In particular, the deuterium abundance is lower at smaller galactocentric radii and in higher mass galaxies, showing that stellar mass loss is more important for fuelling star formation in these regimes (and can even dominate). Gas accreting onto galaxies has a deuterium fraction above that of the galaxies' interstellar medium, but below the primordial fraction, because it is a mix of gas accreting from the intergalactic medium and gas previously ejected or stripped from galaxies.Comment: Accepted for publication in MNRAS. Revised version: expanded discussion and added Figure 2 (residual dependence on iron abundance

Properties of the circumgalactic medium in cosmic ray-dominated galaxy haloes

We investigate the impact of cosmic rays (CRs) on the circumgalactic medium (CGM) in FIRE-2 simulations, for ultra-faint dwarf through Milky Way (MW)-mass haloes hosting star-forming (SF) galaxies. Our CR treatment includes injection by supernovae, anisotropic streaming and diffusion along magnetic field lines, and collisional and streaming losses, with constant parallel diffusivity κ∼3×10²⁹ cm² s⁻¹ chosen to match γ-ray observations. With this, CRs become more important at larger halo masses and lower redshifts, and dominate the pressure in the CGM in MW-mass haloes at z ≲ 1–2. The gas in these ‘CR-dominated’ haloes differs significantly from runs without CRs: the gas is primarily cool (a few ∼10⁴), and the cool phase is volume-filling and has a thermal pressure below that needed for virial or local thermal pressure balance. Ionization of the ‘low’ and ‘mid’ ions in this diffuse cool gas is dominated by photoionization, with O VI columns ≳10^(14.5) cm⁻² at distances ≳150kpc⁠. CR and thermal gas pressure are locally anticorrelated, maintaining total pressure balance, and the CGM gas density profile is determined by the balance of CR pressure gradients and gravity. Neglecting CRs, the same haloes are primarily warm/hot (⁠T≳10⁵) with thermal pressure balancing gravity, collisional ionization dominates, O VI columns are lower and Ne VIII higher, and the cool phase is confined to dense filaments in local thermal pressure equilibrium with the hot phase

But What About... Cosmic Rays, Magnetic Fields, Conduction, & Viscosity in Galaxy Formation

We present a suite of high-resolution cosmological simulations, using the FIRE-2 feedback physics together with explicit treatment of magnetic fields, anisotropic conduction and viscosity, and cosmic rays (CRs) injected by supernovae (including anisotropic diffusion, streaming, adiabatic, hadronic and Coulomb losses). We survey systems from ultra-faint dwarf ($M_{\ast}\sim 10^{4}\,M_{\odot}$, $M_{\rm halo}\sim 10^{9}\,M_{\odot}$) through Milky Way masses, systematically vary CR parameters (e.g. the diffusion coefficient $\kappa$ and streaming velocity), and study an ensemble of galaxy properties (masses, star formation histories, mass profiles, phase structure, morphologies). We confirm previous conclusions that magnetic fields, conduction, and viscosity on resolved ($\gtrsim 1\,$pc) scales have small effects on bulk galaxy properties. CRs have relatively weak effects on all galaxy properties studied in dwarfs ($M_{\ast} \ll 10^{10}\,M_{\odot}$, $M_{\rm halo} \lesssim 10^{11}\,M_{\odot}$), or at high redshifts ($z\gtrsim 1-2$), for any physically-reasonable parameters. However at higher masses ($M_{\rm halo} \gtrsim 10^{11}\,M_{\odot}$) and $z\lesssim 1-2$, CRs can suppress star formation by factors $\sim 2-4$, given relatively high effective diffusion coefficients $\kappa \gtrsim 3\times10^{29}\,{\rm cm^{2}\,s^{-1}}$. At lower $\kappa$, CRs take too long to escape dense star-forming gas and lose energy to hadronic collisions, producing negligible effects on galaxies and violating empirical constraints from $\gamma$-ray emission. But around $\kappa\sim 3\times10^{29}\,{\rm cm^{2}\,s^{-1}}$, CRs escape the galaxy and build up a CR-pressure-dominated halo which supports dense, cool ($T\ll 10^{6}$ K) gas that would otherwise rain onto the galaxy. CR heating (from collisional and streaming losses) is never dominant.Comment: 35 pages, 23 figures. Updated to match published (MNRAS) versio

Exploring the interdependencies of research funders in the UK

Investment in medical research is vital to the continuing improvement of the UK's health and wealth. It is through research that we expand our understanding of disease and develop new treatments for patients. Medical research charities currently contribute over £1 billion annually to medical research in the UK, of which over £350 million is provided by Cancer Research UK. Many charities, including Cancer Research UK, receive no government funding for their research activity. Cancer Research UK is engaged in a programme of work in order to better understand the medical research funding environment and demonstrate the importance of sustained investment. A key part of that is the Office of Health Economics‟ (OHE) 2011 report “Exploring the interdependency between public and charitable medical research”. This study found that there are substantial benefits, both financial and qualitative, from the existence of a variety of funders and that reductions in the level of government financial support for medical research are likely to have broader negative effects. This contributed to other evidence which found that the activities and funding of the charity, public and private sectors respectively are complementary, i.e. mutually reinforcing, rather than duplicative or merely substituting for one another. “Exploring the interdependencies of research funders in the UK” by the Office of Health Economics (OHE) and SPRU: Science and Technology Policy Research at the University of Sussex, represents a continued effort to build the evidence base around the funding of medical research. This report uncovers the extent to which funders of cancer research are interdependent, nationally and internationally. Key figures show that two thirds of publications acknowledging external support have relied on multiple funders, while just under half benefited from overseas funding, and almost a fifth are also supported by industry. In addition the analysis shows that the general public would not want tax funding of cancer research to be reduced, but would not donate enough to charities to compensate for any such reduction