Spatial mapping of hepatitis C prevalence in recent injecting drug users in contact with services.

In developed countries the majority of hepatitis C virus (HCV) infections occur in injecting drug users (IDUs) with prevalence in IDUs often high, but with wide geographical differences within countries. Estimates of local prevalence are needed for planning services for IDUs, but it is not practical to conduct HCV seroprevalence surveys in all areas. In this study survey data from IDUs attending specialist services were collected in 52/149 sites in England between 2006 and 2008. Spatially correlated random-effects models were used to estimate HCV prevalence for all sites, using auxiliary data to aid prediction. Estimates ranged from 14% to 82%, with larger cities, London and the North West having the highest HCV prevalence. The methods used generated robust estimates for each area, with a well-identified spatial pattern that improved predictions. Such models may be of use in other areas of study where surveillance data are sparse

Pulsed pumping of a Bose-Einstein condensate

In this work, we examine a system for coherent transfer of atoms into a Bose-Einstein condensate. We utilize two spatially separate Bose-Einstein condensates in different hyperfine ground states held in the same dc magnetic trap. By means of a pulsed transfer of atoms, we are able to show a clear resonance in the timing of the transfer, both in temperature and number, from which we draw conclusions about the underlying physical process. The results are discussed in the context of the recently demonstrated pumped atom laser.Comment: 5 pages, 5 figures, published in Physical Review

Alpha/beta and gamma interferons are induced by infection with noncytopathic bovine viral diarrhea virus in vivo

In contrast to the results of previous in vitro studies, experimental infection of calves with noncytopathic bovine viral diarrhea virus (ncpBVDV) was found to induce strong alpha/beta and gamma interferon responses in gnotobiotic animals. These responses were associated with depressed levels of transforming growth factor β (TGF-β) in serum. The results of this study indicate that the immunosuppression caused by ncpBVDV is not associated with low interferon responses or elevated levels of TGF-β

Triggering Multi-Actor Change Cascades: Non-Representational Theory and Deep Disaster Risk Management Co-production

Deep-rooted socio-ecological and technical systems, values and lifestyles, ‘locked in’ by vested interests and flows of power, underpin the interconnected problems of climate change, hazard vulnerability and poverty. A ‘shallow’ approach to co-production, with its focus on knowledge exchange and shared learning between individuals, struggles to gain the ‘purchase’ needed to transform these material structures. In this paper we demonstrate that non-representational theory is a good starting point for an alternative ‘deep’ approach to disaster risk management co-production. We review key aspects of non-representational theory and their application to disaster risk management and build a novel hybrid conceptual framework. We use this to analyse a case study of disaster risk management co-production (an aftershock forecasting approach used by humanitarian agencies during the Nepal 2015 earthquake), how social change occurred in this instance, and the role disaster risk management co-production played. We emphasise how change was the consequence of unexpected shifts in assemblages of human, non-human, virtual and real actors. These created ‘events’ that were opportunities for change that were realised with fidelity. Using this analysis, we develop an alternative deep approach to co-production, as ‘a practical means of going on’, and finish with five precepts to guide transformative disaster risk management based on the concept of multi-actor change cascades

Quantum field effects in coupled atomic and molecular Bose-Einstein condensates

This paper examines the parameter regimes in which coupled atomic and molecular Bose-Einstein condensates do not obey the Gross-Pitaevskii equation. Stochastic field equations for coupled atomic and molecular condensates are derived using the functional positive-P representation. These equations describe the full quantum state of the coupled condensates and include the commonly used Gross-Pitaevskii equation as the noiseless limit. The model includes all interactions between the particles, background gas losses, two-body losses and the numerical simulations are performed in three dimensions. It is found that it is possible to differentiate the quantum and semiclassical behaviour when the particle density is sufficiently low and the coupling is sufficiently strong.Comment: 4 postscript figure

General limit to non-destructive optical detection of atoms

We demonstrate that there is a fundamental limit to the sensitivity of phase-based detection of atoms with light for a given maximum level of allowable spontaneous emission. This is a generalisation of previous results for two-level and three-level atoms. The limit is due to an upper bound on the phase shift that can be imparted on a laser beam for a given excited state population. Specifially, we show that no single-pass optical technique using classical light, based on any number of lasers or coherences between any number of levels, can exceed the limit imposed by the two-level atom. This puts significant restrictions on potential non-destructive optical measurement schemes.Comment: 7 pages, 1 figur

Number-Phase Wigner Representation for Efficient Stochastic Simulations

Phase-space representations based on coherent states (P, Q, Wigner) have been successful in the creation of stochastic differential equations (SDEs) for the efficient stochastic simulation of high dimensional quantum systems. However many problems using these techniques remain intractable over long integrations times. We present a number-phase Wigner representation that can be unraveled into SDEs. We demonstrate convergence to the correct solution for an anharmonic oscillator with small dampening for significantly longer than other phase space representations. This process requires an effective sampling of a non-classical probability distribution. We describe and demonstrate a method of achieving this sampling using stochastic weights.Comment: 7 pages, 1 figur

Transverse-mode coupling in a Kerr medium

We analyze nonlinear transverse mode coupling in a Kerr medium placed in an optical cavity and its influence on bistability and different kinds of quantum noise reduction. Even for an input beam that is perfectly matched to a cavity mode, the nonlinear coupling produces an excess noise in the fluctuations of the output beam. Intensity squeezing seems to be particularly robust with respect to mode coupling, while quadrature squeezing is more sensitive. However, it is possible to find a mode the quadrature squeezing of which is not affected by the coupling.Comment: 11 pages, 6 figures, LaTe

Achieving peak brightness in an atom laser

In this paper we present experimental results and theory on the first continuous (long pulse) Raman atom laser. The brightness that can be achieved with this system is three orders of magnitude greater than has been previously demonstrated in any other continuously outcoupled atom laser. In addition, the energy linewidth of a continuous atom laser can be made arbitrarily narrow compared to the mean field energy of a trapped condensate. We analyze the flux and brightness of the atom laser with an analytic model that shows excellent agreement with experiment with no adjustable parameters.Comment: 4 pages, 4 black and white figures, submitted to Physical Revie