Myocardial Relaxation Is Accelerated by Fast Stretch, Not Reduced Afterload

Fast relaxation of cross-bridge generated force in the myocardium facilitates efficient diastolic function. Recently published research studying mechanisms that modulate the relaxation rate has focused on molecular factors. Mechanical factors have received less attention since the 1980s when seminal work established the theory that reducing afterload accelerates the relaxation rate. Clinical trials using afterload reducing drugs, partially based on this theory, have thus far failed to improve outcomes for patients with diastolic dysfunction. Therefore, we reevaluated the protocols that suggest reducing afterload accelerates the relaxation rate and identified that myocardial relengthening was a potential confounding factor. We hypothesized that the speed of myocardial relengthening at end systole (end systolic strain rate), and not afterload, modulates relaxation rate and tested this hypothesis using electrically-stimulated trabeculae from mice, rats, and humans. We used load-clamp techniques to vary afterload and end systolic strain rate independently. Our data show that the rate of relaxation increases monotonically with end systolic strain rate but is not altered by afterload. Computer simulations mimic this behavior and suggest that fast relengthening quickens relaxation by accelerating the detachment of cross-bridges. The relationship between relaxation rate and strain rate is novel and upends the prevailing theory that afterload modifies relaxation. In conclusion, myocardial relaxation is mechanically modified by the rate of stretch at end systole. The rate of myocardial relengthening at end systole may be a new diagnostic indicator or target for treatment of diastolic dysfunction

Far Ultraviolet Spectroscopic Explorer Observations of a Supernova Remnant in the Line of Sight to HD 5980 in the Small Magellanic Cloud

We report a detection of far ultraviolet absorption from the supernova remnant SNR 0057 - 7226 in the Small Magellanic Cloud (SMC). The absorption is seen in the Far Ultraviolet Spectroscopic Explorer (FUSE) spectrum of the LBV/WR star HD 5980. Absorption from O VI 1032 and C III 977 is seen at a velocity of +300 km/s with respect to the Galactic absorption lines, +170 km/s with respect to the SMC absorption. The O VI 1038 line is contaminated by H_2 absorption, but is present. These lines are not seen in the FUSE spectrum of Sk80, only ~1' (~17 pc) away from HD 5980. No blue-shifted O VI 1032 absorption from the SNR is seen in the FUSE spectrum. The O VI 1032 line in the SNR is well described by a Gaussian with FWHM=75 km/s. We find log N(O VI)=14.33-14.43, which is roughly 50% of the rest of the O VI column in the SMC (excluding the SNR) and greater than the O VI column in the Milky Way halo along this sight line. The N(C IV)/N(O VI) ratio for the SNR absorption is in the range of 0.12-0.17, similar to the value seen in the Milky Way disk, and lower than the halo value, supporting models in which SNRs produce the highly ionized gas close to the plane of the Galaxy, while other mechanisms occur in the halo. The N(C IV)/N(O VI) ratio is also lower than the SMC ratio along this sight line, suggesting that other mechanisms contribute to the creation of the global hot ionized medium in the SMC. The O VI, C IV, and Si IV apparent column density profiles suggest the presence of a multi-phase shell followed by a region of higher temperature gas.Comment: 7 pages, 3 figures, 2 tables, uses emulateapj5.sty. Accepted for publication in ApJ Letter

The Massive Stellar Population in the Diffuse Ionized Gas of M33

We compare Far-UV, H alpha, and optical broadband images of the nearby spiral galaxy M33, to investigate the massive stars associated with the diffuse ionized gas. The H-alpha/FUV ratio is higher in HII regions than in the DIG, possibly indicating that an older population ionizes the DIG. The broad-band colors support this conclusion. The HII region population is consistent with a young burst, while the DIG colors resemble an older population with constant star formation. Our results indicate that there may be enough massive field stars to ionize the DIG, without the need for photon leakage from HII regions

Diffuse Ionized Gas in Three Sculptor Group Galaxies

We present a study of the diffuse ionized gas (DIG) in three Sculptor group galaxies: NGC 55, NGC 253, and NGC 300. The study is based on narrow band imagery in H-alpha+[NII](6548+6583A) and [SII] (6717+6731A). We find that DIG contributes 33 to 58% of the total H-alpha luminosity in these galaxies, or 30 to 54% after correcting for scattered light. We find that NGC 300 has a higher fractional DIG luminosity than the other galaxies in our sample, but it is not clear whether this is a significant difference or an effect of the high inclination of the other galaxies. The diffuse emission, averaged over the optical extent of the disk, has a face-on emission measure of 5 to 10 pc cm^{-6}. The DIG is concentrated near HII regions, although significant emission is seen at large distances from HII regions, up to 0.5 to 1 kpc. The [SII]/(H-alpha+[NII]) ratio is enhanced in the DIG, typically around 0.3 to 0.5, compared to 0.2 for the HII regions in these galaxies. These properties are similar to those measured for the DIG in the Milky Way and in other nearby spirals. The line ratios, large-scale distribution, and energy requirement suggest that photoionization is the dominant ionization mechanism.Comment: 19 pages, LaTex, 3 LaTex tables, 4 Postscript figures, 3 jpeg plates. Plates also available at ftp://astro.nmsu.edu/pub/choopes/ , accepted for publication in the Astronomical Journal. Replaced version includes plate

Delayed Sternal Closure Does Not Reduce Complications Associated with Coagulopathy and Right Ventricular Failure After Left Ventricular Assist Device Implantation

Delayed sternal closure (DSC) is occasionally adopted after implantation of left ventricular assist device (LVAD). Recent studies suggest that DSC be used for high risk group of patients with coagulopathy, hemodynamic instability or right ventricular failure. However, whether DSC is efficacious for bleeding complication or right ventricular failure is not known. This study is single center analysis of 52 patients, who underwent LVAD implantation. Of those 52 patients, 40 consecutive patients underwent DSC routinely. The sternum was left open with vacuum assist device after implantation of LVAD. Perioperative outcome of the patients who underwent routine DSC were compared with 12 patients who had immediate sternal closure (IC). Mean Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS) level of IC group and DSC group were 2.7 and 2.6, respectively. Postoperative bleeding (643 vs. 1469 ml, p \u3c 0.001), duration of inotropic support (109 vs. 172 h, p = 0.034), and time to extubation (26 vs. 52 h, p = 0.005) were significantly increased in DSC group. Length of ICU stay (14 vs. 15 days, p = 0.234) and hospital stay (28 vs. 20 days, p = 0.145) were similar. Incidence of right ventricular failure and tamponade were similar in the two groups. Routine DSC after implantation of an LVAD did not prove to be beneficial in reducing complications associated with coagulopathy and hemodynamic instability including cardiac tamponade or right ventricular failure. We suggest that DSC be selectively applied for patients undergoing LVAD implant

Fluid Structure Interaction Analysis for Prediction of Centrifugal Compressor Dynamic Stresses

TutorialCentrifugal compressor impellers experience dynamic loading from flow structures generated by upstream and downstream compressor components. This loading can cause high cycle fatigue and ultimately impeller failure if not accounted for during the design of the impeller. This paper reviews the use of Fluid Structure Interaction as a method for the prediction of these unsteady pressures and resultant dynamic stresses. This paper describes a recent analysis effort to predict dynamic pressures and aerodynamic damping in an industrial centrifugal compressor application. Specific fluid meshing and solution strategies are discussed including a direct time dependent full 360 degree sliding mesh solution and a single passage pitch change solution, using either a Time Transformation or a Fourier Transformation method. Also discussed is the methodology for imposing dynamic pressures from a computational fluid dynamic (CFD) analysis on a forced harmonic structural response analysis to predict unsteady impeller stresses. Particular attention is paid to the post processing of the predicted stress field to inform a prediction of the acceptability of the fatigue performance of the impeller