42 research outputs found

    Bounds in Competing Risks Models and the War on Cancer

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    In 1971 President Nixon declared war on cancer and increased the federal funds allocated to cancer research dramatically. Thirty years later, many have declared this war a failure. Overall cancer statistics confirm this view: age-adjusted mortality in 2000 was essentially unchanged from the early 1970s. At the same time, age-adjusted mortality rates from cardiovascular disease have fallen quite dramatically. Since the causes underlying cancer and cardiovascular disease are likely to be correlated, the decline in mortality rates from cardiovascular disease may be somewhat responsible for the rise in cancer mortality. It is natural to model mortality with more than one cause of death as a competing risks model. Such models are fundamentally unidentified, and it is therefore difficult to get a clear picture of the progress in cancer. This paper derives bounds for aspects of the underlying distributions under a number of different assumptions. Most importantly, we do not assume that the underlying risks are independent, and impose weak parametric assumptions in order to obtain identification. The theoretical contribution of the paper is to provide a framework to estimate competing risk models with interval data and discrete explanatory variables, both of which are common in empirical applications. We use our method to estimate changes in cancer and cardiovascular mortality since 1970. The estimated bounds for the effect of time on the duration until death for either cause are fairly tight and we find that trends in cancer show much larger improvements than previously estimated. For example, we find that time until death from cancer increased by about 10% for white males and 20% for white women.

    Nonlinear models with panel data

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    Panel data play an important role in empirical economics. With panel data one can answer questions about microeconomic dynamic behavior that could not be answered with cross sectional data. Panel data techniques are also useful for analyzing cross sectional data with grouping. This paper discusses some issues related to specification and estimation of nonlinear models using panel data.This paper was supported by the National Science Foundation, the Gregory C. Chow Econometric Research Program at Princeton University, and Danish National Research Foundation (through CAM at the University of Copenhagen).info:eu-repo/semantics/publishedVersio

    Non-linear models with panel data

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    Panel data play an important role in empirical economics. With panel data one can answer questions about microeconomic dynamic behavior that could not be answered with cross sectional data. Panel data techniques are also useful for analyzing cross sectional data with grouping. This paper discusses some issues related to specification estimation of nonlinear models using panel data.

    Molecular and functional properties of P2X receptors—recent progress and persisting challenges

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    Identification Results for Duration Models with Multiple Spells.

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    The purpose of this paper is to investigate the identifiability of duration models with multiple spells. The author proves that the results of C. Elbers and G. Ridder (1982) and J. J. Heckman and B. Singer (1984) can be generalized.to multispell models with lagged duration dependence. He also proves that, without lagged duration dependence, the identification result does not depend on moment conditions or tail conditions on the mixing distribution. This resul t is in contrast to Ridder's (1990) result for single-spell models. Copyright 1993 by The Review of Economic Studies Limited.

    Trimmed LAD and Least Squares Estimation of Truncated and Censored Regression Models with Fixed Effects.

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    This paper considers estimation of truncated.and censored regression models with fixed effects. Up until now, no estimator has been shown to be consistent as the cross-section dimension increases with the time dimension fixed. Trimmed least absolute deviations and trimmed least squares estimators are proposed for the case where the panel is of length two, and it is proven that they are consistent and asymptotically normal. It is not necessary to maintain parametric assumptions on the error terms to obtain this result. A small scale Monte Carlo study demonstrates that these estimators can perform well in small samples. Copyright 1992 by The Econometric Society.
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