Primary Study for the Therapeutic Dose and Time Window of Picroside II in Treating Cerebral Ischemic Injury in Rats

The aim of this study was to explore the optimal therapeutic dose and time window of picroside II for treating cerebral ischemic injury in rats according to the orthogonal test. The middle cerebral artery occlusion (MCAO) models were established by intraluminally inserting a thread into middle cerebral artery (MCA) from left external carotid artery (ECA). The successful rat models were randomly divided into 16 groups according to the orthogonal layout of [L16(45)] and treated by injecting picroside II intraperitoneally with different doses at various times. The neurological behavioral function was evaluated by Bederson’s test and the cerebral infarction volume was measured by tetrazolium chloride (TTC) staining. The expressions of neuron specific enolase (NSE) and neuroglial mark-protein S-100 were determined by immunohistochemisty assay. The results indicated that the optimal compositions of the therapeutic dose and time window of picroside II in treating cerebral ischemic injury were ischemia 1.5 h with 20 mg/kg body weight according to Bederson’s test, 1.0 h with 20 mg/kg body weight according to cerebral infarction volume, 1.5 h with 20 mg/kg body weight according to the expressions of NSE and S-100 respectively. Based on the principle of the minimization of medication dose and maximization of therapeutic time window, the optimal composition of the therapeutic dose and time window of picroside II in treating cerebral ischemic injury should be achieved by injecting picroside II intraperitoneally with 20 mg/kg body weight at ischemia 1.5 h

Squeeze Behaviors of Magnetorheological Fluids under Different Compressive Speeds

The compression tests under the unidirection for magnetorheological (MR) fluids have been studied at different compressive speeds. The results indicated that curves of compressive stress under different compression speeds at the applied magnetic field of 0.15 T overlapped well and were shown to be an exponent of about 1 of the initial gap distance in the elastic deformation region and accorded well with the description of continuous media theory. The difference in compressive stress curves increases significantly with an increasing magnetic field. At this time, the continuous media theory description could not be accounted for the effect of compressive speed on the compression of MR fluid, which seems to deviate from the Deborah number prediction under the lower compressive speeds. An explanation based on the two-phase flow due to aggregations of particle chains resulting in much longer relaxation times at a lower compressive speed was proposed to explain this deviation. The results have guiding significance for the theoretical design and process parameter optimization for the squeeze-assisted MR devices such as MR dampers and MR clutches based on the compressive resistance

A Comparative Analysis of Measured and Calculated Compressive Stresses of Magnetorheological Fluids under Unidirectional Compression and Constant Area

Unidirectional compressive properties of magnetorheological (MR) fluids have been investigated under slow compression and constant area with different magnetic fields and different initial gap distances. Experimental tests of unidirectional compression were firstly carried out by using a commercial plate–plate rheometer. The theoretical model based on the continuous squeeze flow theory was developed to calculate the compressive stress. The comparisons between the measured and calculated compressive stresses of MR fluids were made. It showed that the compression resistance of the MR fluid in the magnetic field was much higher than that predicted by the theory. With the increasing magnetic flux density, the deviation between measured and calculated curves accelerated. Characteristics of the compressive stress variation with the reduction in gap distance have been analyzed. The structure strengthening effect induced by the chain structure aggregation in squeeze mode has been used to explain this deviation

Effect of cold rolling deformation on the pitting corrosion behavior of high-strength metastable austenitic stainless steel 14Cr10Mn in simulated coastal atmospheric environments

The pitting corrosion behaviors of high-strength metastable austenitic stainless steel (MASS) 14Cr10Mn with different cold rolling reductions (0 %, 10 % and 20 %) were investigated in simulated coastal atmospheric environments by scanning electron microscope (SEM), transmission electron microscope (TEM), X-ray photoelectron spectroscopy (XPS), electrochemical measurements and cyclic corrosion test. The cold rolling deformation noticeably increases the dislocation density in the steel. As the cold rolling reduction changes from 0 % to 20 %, the pitting potential and the polarization resistance decrease to some extent in 1 wt% NaCl solution. The cold rolling deformation increases the defect density and the contents of (Fe,Cr)-oxyhydroxides/hydroxides in the passive film on the specimen surface. After the wet-dry cyclic corrosion test, the corrosion pits initiate at the deformation band regions. The quantity, diameter and depth of the pits gradually increase with enlarging the cold rolling reduction

The Effect of Hormone Types, Concentrations, and Treatment Times on the Rooting Traits of <i>Morus</i> ‘Yueshenda 10’ Softwood Cuttings

Enhancing the capacity of fruit trees to propagate via cuttings is an important endeavor for the high-quality development of the fruit industry. Optimizing the conditions for the cutting propagation of mulberry seedlings is an important factor that influences the industrial production of this plant; however, the currently used mulberry breeding technology system is not mature. In this experiment, an orthogonal design was used to intercept semi-woody shoots of Yueshenda 10 as cuttings and set different hormone concentrations (200, 500, 800, and 1000 mg/L), different hormone types (NAA, IBA, IAA, and ABT-1), and different soaking times (10, 30, 60, and 120 min) for cuttings. The effects of the three factors on the rooting of mulberry cuttings were investigated by soaking the cuttings in clean water for 10 min as a control. The results showed that the primary and secondary order of the three factors affecting the rooting rate of cuttings was hormone concentration > hormone type > soaking time, and the concentration of exogenous hormones had a significant impact on all rooting indicators (p < 0.05). In addition, the rooting rate (66.24%), average number of roots (7.54 roots/plant), and rooting effect index (4.23) of Yueshenda 10 cuttings reached the optimal level when soaked with 800 mg/L ABT-1 for 30 min. The longest root length (10.20 cm) and average root length (4.44 cm) of cuttings achieved the best results when soaked with 800 mg/L NAA for 60 min and 500 mg/L NAA for 30 min, respectively. On balance, it is considered that the preferred solution is to soak the cuttings of Yueshenda 10 with 800 mg/L ABT1 solution for 0.5 h

Thermal Fatigue Characteristics of Type 309 Austenitic Stainless Steel for Automotive Manifolds

The thermal fatigue behavior of type 309 austenitic stainless steel was investigated by cyclic tests ranged from 100 &#176;C to the maximum temperatures 800 and 900 &#176;C. The microstructures of the specimens were characterized by optical microscope, scanning electron microscope and X-ray diffraction. With changing the maximum temperature from 800 to 900 &#176;C, the stainless steel exhibits much lower strength, higher elongation and a decrease of fatigue life about 56.6%. After the thermal fatigue failure, the specimens show micro-void coalescence fractures caused by the creep during the holding period at the maximum temperatures, and the quasi-cleavage feature also appears in the case of the maximum temperature 800 &#176;C. During the thermal fatigue processes, the cavities usually form at the grain and twin boundaries, facilitating the initiation and growth of cracks. Furthermore, the high-temperature oxidation produces oxides on the specimen surfaces and in the cracks, deteriorating thermal fatigue properties. With an increase in the maximum temperature, the enhanced synergetic effect of strength, grain size, creep and oxidation is responsible for the accelerated fatigue failure of 309 stainless steel during the thermal cycles

Void Formation and Crack Propagation in a Cr–Mn–N Metastable Austenitic Stainless Steel During Bending

Microstructure evolution via deformation-induced martensitic transformation, void formation, and crack propagation is investigated in a metastable austenitic Cr–Mn–N stainless steel for up to 90° bending using a combination of electron backscattering diffraction and parent grain reconstruction. Stress–strain heterogeneity and stress triaxiality studied using finite-element analysis reveal that the inner and outer radii are in approximately uniaxial compressive and tensile stress states, respectively, with the outer radius showing higher values for von Mises and principal stresses and equivalent strain. Voids are observed at both austenite/α′-martensite and α′/α′-martensite interfaces. Parent grain reconstruction applied to the 90° bending sample reveal that the cracks at α′/α′-martensite interfaces tend to propagate predominantly along intergranular parent austenite grain boundaries. It is also found that both intragranular and intergranular cracks in parent austenite tend to propagate between α′-martensite child–child grains comprising the same crystallographic packets. This is the first study of its kind to comprehensively show this phenomenon. A representative example of intergranular crack propagation within a (Formula presented.) ‖normal direction (ND)-oriented parent austenite grain is also demonstrated