Supporting Information from Copper-catalysed regioselective sulfenylation of indoles with sodium sulfinates

A copper-catalysed sulfenylation of indoles with sodium sulfinates to afford 3-sulfenylindoles in good-to-excellent yields in DMF is described. In the process, DMF is not only used as a solvent, but also as a reductant. This transformation features easy operation, mild reaction conditions and good functional group tolerance

Self-Organization and Vesicle Formation of Amphiphilic Fulleromonodendrons Bearing Oligo(poly(ethylene oxide)) Chains

A new series of <i>N</i>-methylfulleropyrrolidines bearing oligo­(poly­(ethylene oxide))-appended Percec monodendrons (fulleromonodendrons, <b>4a</b>–<b>f</b>) have been synthesized. The substituted position of the oligo­(poly­(ethylene oxide)) chain(s) on the phenyl group of the Percec monodendron for <b>4a</b>–<b>f</b> was varied, which is at the 4-, 2,4-, 3,5-, 3,4,5-, 2,3,4- and 2,4,6- position, respectively. <b>4a</b>–<b>e</b> are obtained as solids at 25 °C and can self-organize into lamellar phases as revealed by X-ray diffraction (XRD) and small-angle X-ray scattering (SAXS) measurements, while <b>4f</b> appears as a viscous liquid. The substitution patterns of the oligo­(poly­(ethylene oxide)) chain(s) also significantly influence the solubility of <b>4a</b>–<b>f</b>, especially in ethanol and water. Formation of self-organized supramolecular structures of <b>4d</b> and <b>4e</b> in water as well as <b>4d</b> in ethanol is evidenced from UV–vis and dynamic light scattering (DLS) measurements. Further studies in water using various imaging techniques including transmission electron microscopy (TEM), freeze-fracture TEM (FF-TEM), cryo-TEM and atomic force microscopy (AFM) observations revealed the formation of well-defined vesicles for <b>4d</b> and plate-like aggregates for <b>4e</b>, indicating that the aggregation behavior of the fulleromonodendrons is highly dependent on their molecular structures. For <b>4d</b> in ethanol, only irregular aggregates were noticed, indicating the solvent also plays a role on regulating the aggregation behavior. After functionalization with the Percec monodendrons, <b>4a</b>–<b>f</b> can preserve the intriguing electrochemical properties of pristine C₆₀ as revealed by cyclic voltammetries. The thermotropic properties of <b>4a</b>–<b>f</b> have also been investigated. It was found that all of them show good thermal stability, but no mesophases were detected within the investigated temperature ranges

DataSheet_1_Immune checkpoint inhibitors-related pancreatitis with fulminant type 1 diabetes mellitus: case report and literature review.docx

Immune checkpoint inhibitors (ICIs) are increasingly being used in the treatment of advanced human malignancies. ICIs-related adverse events, including pancreatitis and diabetes, have been individually characterized in the literature. The co-occurrence of ICIs-related pancreatitis with diabetes is rare and easily overlooked, but it is often severe or fatal. We present a patient with renal tumor resection who was treated with injection of the PD-L1 inhibitor toripalimab and eventually developed acute pancreatitis and fulminant type 1 diabetes mellitus. In addition, we conducted a literature review of ICIs-related pancreatitis with diabetes. The case in our report presented with paroxysmal abdominal pain and loss of appetite. Intravenous fluids and insulin infusion improved the patient’s pancreatitis and explosive hyperglycemia. This article suggests that ICIs can affect endocrine and exocrine functions of the pancreas, while providing information and new perspectives for the diagnosis and treatment of this challenging rare disease, helping inspire clinicians for the early identification and effective management of similar cases.</p

Additional file 1 of Network module analysis and molecular docking-based study on the mechanism of astragali radix against non-small cell lung cancer

Additional file 1: Supplementary Table 1. Pubchem compound information of drugs

Clinicopathologic features in 136 HCC patients treated with TACE.

<p>Clinicopathologic features in 136 HCC patients treated with TACE.</p

Receiver operating characteristic curve analysis for predicting prognostic accuracy of hepatocellular carcinoma with TACE treatment.

<p>ROC curves for the combination of AFP and satellite nodules, miR-200a and the combination of AFP, satellite nodules and miR-200a in total 136 patients and subgroup of HCC patients with normal (≤20 ng/ml), elevated (20–400 ng/ml) and diagnostic (>400 ng/ml) AFP level, respectively. The sensitivity, specificity and AUC were indicated below each ROC graph. SN: satellite nodules.</p

Association of clinical parameters with overall survival by Kaplan-Meier curves and the log-rank test.

<p><b>A.</b> AFP-normal, AFP-elevated or AFP-diagnostic patients. <b>B.</b> Patients with BCLC stages A+B or C. <b>C.</b> Patients with Child-Puge class A or B. <b>D.</b> Patients with or without satellite nodules. SN: satellite nodules.</p

Univariate and Multivariate Cox proportional hazards regression analysis of miRNAs in relation to HCC outcome.

<p>HR, hazard ratio; CI, confidence interval; miR, microRNA.</p><p>Univariate and Multivariate Cox proportional hazards regression analysis of miRNAs in relation to HCC outcome.</p

The levels of serum miRNAs were associated with overall survival.

<p><b>A.</b> Patients with low or high expression of miR-200a (Cutoff value: Delta CT = 16.02). <b>B.</b> Patients with low or high expression of miR-21 (Cutoff value: Delta CT = 6.08). <b>C.</b> Patients with low or high expression of miR-122 (Cutoff value: Delta CT = 6.88). <b>D.</b> Patients with low or high expression of miR-224-5p (Cutoff value: Delta CT = 14.22). <b>E.</b> The relative expression level of serum miR-200a, miR-21, miR-122 and miR-224-5p in the group of HCC patients with high expression level was normalized by the group of patients with low expression level (set as 1), respectively. Mean ± s.d.</p

Univariate and Multivariate Cox proportional hazards regression analysis of clinical parameters in relation to disease outcome.

<p>HR, hazard ratio; CI, confidence interval; BCLC, Barcelona Clinic Liver Cancer; AFP, alpha-fetoprotein.</p><p>Univariate and Multivariate Cox proportional hazards regression analysis of clinical parameters in relation to disease outcome.</p