Paradoxical phenomenon in urban renewal practices: promotion of sustainable construction versus buildings’ short lifespan

The current urban renewal programs in some developing countries, such as China, are at the expense of demolishing a huge number of existing buildings without distinction. As a consequence, the buildings’ short lifespan due to premature demolition and resultant adverse impacts on environment and society have been criticized for not being in line with sustainable development principles. This study therefore examines impacts of urban renewal practices on buildings’ lifespan by referring to a typical urban renewal region in western China – the Gailanxi region of Chongqing city which is considered representative. Findings show in current practices, little consideration is given to the implications of building demolitions across economic, social and environmental horizons collectively. As a result, premature demolition due to requirements of urban renewal has been a major factor leading to the significantly short lifespan of buildings. This is against the core intention of implementing urban renewal, which is promoting sustainability of the cities. Particularly, buildings’ short lifespan results in consequences against sustainable construction principles, such as energy and resources waste, construction waste generation, environmental pollution, and higher lifecycle costs of buildings. Furthermore, building demolitions without distinction lead to losses of valuable historic buildings. Therefore, the urban renewal process presents a paradoxical phenomenon: the promotion of sustainable construction versus buildings’ short lifespan. The dominance of economic consideration in the decision-making on buildings is considered as the underlying reason to the paradox. The learned experience presented in this study should be built into the decision-making process for carrying out future urban renewal programs

Zhilong Huoxue Tongyu capsule attenuates intracerebral hemorrhage induced redox imbalance by modulation of Nrf2 signaling pathway

Background: One of the severely debilitating and fatal subtypes of hemorrhagic stroke is intracerebral hemorrhage (ICH), which lacks an adequate cure at present. The Zhilong Huoxue Tongyu (ZLHXTY) capsule has been utilized effectively since last decade to treat ICH, in some provinces of China but the scientific basis for its mechanism is lacking. Purpose: To investigate the neuroprotective role of ZLHXTY capsules for ICH-induced oxidative injury through the regulation of redox imbalance with the Nrf2 signaling pathway.Methods: Autologous blood injection model of ICH in C57BL/6J mice was employed. Three treatment groups received ZLHXTY once daily through oral gavage at doses 0.35 g/kg, 0.7 g/kg, and 1.4 g/kg, started after 2 h and continued for 72 h of ICH induction. The neurological outcome was measured using a balance beam test. Serum was tested for inflammatory markers IL-1β, IL-6, and TNF-α through ELISA, oxidative stress through hydrogen peroxide content assay, and antioxidant status by total antioxidant capacity (T-AOC) assay. Nuclear extract from brain tissue was assayed for Nrf2 transcriptional factor activity. RT-qPCR was performed for Nfe2l2, Sod1, Hmox1, Nqo1, and Mgst1; and Western blotting for determination of protein expression of Nrf2, p62, Pp62, Keap, HO1, and NQO1. Fluoro-jade C staining was also used to examine neuronal damage.Results: ZLHXTY capsule treatment following ICH demonstrated a protective effect against oxidative brain injury. Neurological scoring showed improvement in behavioral outcomes. ELISA-based identification demonstrated a significant decline in the expression of serum inflammatory markers. Hydrogen peroxide content in serum was found to be reduced. The total antioxidant capacity was also reduced in serum, but the ZLHXTY extract showed a concentration-dependent increase in T-AOC speculating at its intrinsic antioxidant potential. Nrf2 transcriptional factor activity, mRNA and protein expression analyses revealed normalization of Nrf2 and its downstream targets, which were previously elevated as a result of oxidative stress induced by ICH. Neuronal damage was also reduced markedly after ZLHXTY treatment as revealed by Fluoro-jade C staining. Conclusion: ZLHXTY capsules possess an intrinsic antioxidant potential that can modulate the ICH-induced redox imbalance in the brain as revealed by the normalization of Nrf2 and its downstream antioxidant targets

Application of Helmert Variance Component Based Adaptive Kalman Filter in Multi-GNSS PPP/INS Tightly Coupled Integration

The integration of the Global Positioning System (GPS) and the Inertial Navigation System (INS) based on Real-time Kinematic (RTK) and Single Point Positioning (SPP) technology have been applied as a powerful approach in kinematic positioning and attitude determination. However, the accuracy of RTK and SPP based GPS/INS integration mode will degrade visibly along with the increasing user-base distance and the quality of pseudo-range. In order to overcome such weaknesses, the tightly coupled integration between GPS Precise Point Positioning (PPP) and INS was proposed recently. Because of the rapid development of the multi-constellation Global Navigation Satellite System (multi-GNSS), we introduce the multi-GNSS into the tightly coupled integration of PPP and INS in this paper. Meanwhile, in order to weaken the impacts of the GNSS observations with low quality and the inaccurate state model on the performance of the multi-GNSS PPP/INS tightly coupled integration, the Helmert variance component estimation based adaptive Kalman filter is employed in the algorithm implementation. Finally, a set of vehicle-borne GPS + BeiDou + GLONASS and Micro-Electro-Mechanical-Systems (MEMS) INS data is analyzed to evaluate the performance of such algorithm. The statistics indicate that the performance of the multi-GNSS PPP/INS tightly coupled integration can be enhanced significantly in terms of both position accuracy and convergence time

Exploration of the atomic-level structures of the icosahedral clusters in Cu–Zr–Al ternary metallic glasses via first-principles theory

The atomic-level structures of the icosahedral clusters in Cu–Zr–Al ternary metallic glasses were studied via the first-principles theory. The rules of icosahedra stability were determined. Icosahedra with a better chemical order or with a better symmetry exhibited a better stability. The strong connectivity between Al atom and Cu and Zr atoms was observed as demonstrated by the obvious degree of ‘bond shortening’. The Al atom contributed more to the structural stability when used as the central atom than the other atoms. Therefore, the addition of even a small amount of Al atom to the Cu–Zr binary system remarkably improved the stability of the icosahedron structures. The continued addition of Al atoms had a lower contribution to the improvement to the glass-forming ability of the Cu–Zr–Al alloys

A Novel Organoclay with Antibacterial Activity Prepared from Montmorillonite and Chlorhexidini Acetas

A series of novel organoclays with antibacterial activity were synthesized using Ca-montmorillonite and Chlorhexidini Acetas (CA) by ion-exchange. The resultant organoclays were characterized using X-ray diffraction (XRD), high-resolution thermogravimetric analysis (HRTG) and Fourier transform infrared spectroscopy (FTIR). Their antibacterial activity was assayed by so-called halo method. In the organoclay prepared at low CA concentration, CA ions within the clay interlayer adopt a lateral monolayer while a ‘kink’ state or a special state with partial overlapping of the intercalated CA in the organoclays prepared at 1.0 – 4.0 CEC. HRTG analysis demonstrates that CA located outside the clay interlayer exists in all synthesised organoclays, resulting from the complex molecular configuration of CA. The dramatic decrease of the surface adsorbed water and interlayer water is caused by the surface property transformation and the replacement of hydrated cations by cationic surfactant. These observations are supported by the results of FTIR. Antibacterial activity test against E. coli demonstrates that the antibacterial activity of the resultant organoclays strongly depends on the content of CA. Meanwhile, the resultant organoclay shows a long-term antibacterial activity that can last for at least one year. These novel organoclays are of potential use in synthesis of organoclay-based materials with antibacterial activity

Grafting of montmorillonite with different functional silanes via two different reaction systems

Silane grafted montmorillonites were synthesized by using 3-aminopropyltriethoxysilane and trimethylchlorosilane via two different grafting reaction systems: (a) ethanol-water mixture and (b) vapour of silane. The resulting products were investigated using Fourier transform infrared (FTIR), X-ray diffraction (XRD), thermogravimetric analysis (TGA). XRD patterns demonstrate that silane was intercalated into the montmorillonite gallery, as indicated by the increase of the basal spacing. The product prepared by vapor deposition has a larger basal spacing than that obtained from solution, due to the different extent of silane hydrolysis in various grafting systems. TGA curves indicate that the methyl groups penetrate into the siloxane clay are the primary reason for the decrease of the dehydroxylation temperature of the grafted products. 3-aminopropyltriethoxysilane in the grafted montmorillonite adopts a bilayer arrangement while trimethylchlorosilane adopts a monolayer arrangement within the clay gallery