Dimethyl 3-(cyclo­propyl­carbon­yl)pyrrolo­[2,1-a]isoquinoline-1,2-dicarboxyl­ate

In the mol­ecular structure of the title compound, C20H17NO5, two intra­molecular C—H⋯O hydrogen bond generate six- and seven-membered ring motifs. The dihedral angles between the almost planar 13-atom triple-fused-ring system (r.m.s. deviation = 0.003 Å) and the planes of the two meth­oxy­carbonyl substituents are 61.7 (2) and 33.01 (10)°

Self-Stacked Growth of Cu₉S₅ Nanostructures with Morphology Regulation as an Electromagnetic Wave Absorber

The development of thin semiconductor nanomaterial sulfide absorbers with strong absorption and a wide bandwidth can effectively expand the application of sulfide in the field of electromagnetic wave absorption. Structural analysis of the crystallographic information, epitaxial elemental information, microscopic morphological structure information, electromagnetic wave parameter information, and radar scattering cross-sectional area characteristics of Cu9S5 demonstrated that the morphological regulation strategy applied to Cu9S5 nanomaterials achieved the expected results. The crystalline shape of the nanomaterial was pure. The prepared Cu9S5 nanomaterial had multiple electromagnetic wave loss mechanisms. Among them, the minimum reflection loss of the polyhedral Cu9S5 nanomaterial was −60.77 dB at 1.78 mm, and the effective absorption bandwidth of the porous sheet Cu9S5 nanomaterial reached 5.2 GHz at 1.9 mm. This work provided a strategy for the application of semiconductor Cu9S5 functional nanomaterials in the field of electromagnetic wave absorption and can serve as a basis for subsequent in-depth studies on semiconductor metal sulfides. Nanostructured Cu9S5 has excellent research prospects in the field of microwave absorption

Next generation sequencing based pathogen analysis in a patient with neurocysticercosis: a case report

Abstract Background Accurate and early diagnosis of neurocysticercosis (NCC) remains a challenge due to the heterogeneity of its clinical, immunological and imaging characteristics. The presence of cysticercus DNA in cerebrospinal fluid (CSF) of NCC patients has been previously detected via conventional PCR assays. To the best of our knowledge, the use of CSF Next-Generation Sequencing (NGS) based pathogen analysis in patients with NCC infection has never been reported. Case presentation This study reports the clinical, imaging, and immunological features of a patient initially presenting with several months of headache who further developed a pure sensory stroke. NGS was used to detect the pathogen, and her CSF demonstrated the presence of Taenia solium-DNA. This finding was confirmed by a positive reaction to CSF cysticercosis antibodies. After antiparasitic treatment, secondary CSF NGS revealed the DNA index have dropped considerably compared to the initial NGS readings. Conclusions NGS is a promising tool for the early and accurate diagnosis of central nervous system (CNS) infection, especially in the setting of atypical clinical manifestations. Further studies are required to evaluate the persistence of DNA in the CSF of patients