Formation of Coronene Clusters in Concentration and Temperature Controlled Two-Dimensional Porous Network

In this research, with the assistance of scanning tunneling microscopy (STM), we observed the two-dimensional (2D) self-assembly transition of a star-shaped oligofluorene derivative (StOF) from disordered structure to honeycomb network by adjusting StOF concentration in solution. By introducing guest molecules coronene (COR), we for the first time achieved novel triangle-shaped COR trimers on liquid/highly oriented pyrolytic graphite (HOPG) interface in both honeycomb network and the disordered structure. In thermal tests, the COR/StOF–disorder system underwent a structural conformation to form well-ordered ladder structures, while the COR/StOF–honeycomb system remained the perfect hexagonal network with COR trimers included in the cavities. Density functional theory (DFT) calculations have been employed to investigate the forming mechanism of the molecular nanoarrays. These studies are expected to enhance controlling on 2D self-assembly and provide a facial approach toward constructing on-surface molecular clusters

Analysis of anti-asthmatic drug patents published in China between 2004 and 2013

<p><b>Introduction</b>: We previously reported that 789 anti-allergic patents were granted in China between 1988 and 2008, but the number of patents seems to have grown much faster in China in recent years. Therefore, it is necessary to analyse the patents for anti-asthmatic products between 2004 and 2013 to give pharmaceutical companies and individuals a better understanding of potential candidates for anti-asthmatic drug development from patents published in China.</p> <p><b>Areas covered</b>: The current report analyses the scientific progress that supports anti-asthmatic drug patent applications and reviews the published patent literature in China from 2004 to 2013.</p> <p><b>Expert opinion</b>: The rapid increase in the number of anti-asthmatic patents in China indicates that more specific discoveries have been made and that more people are aware of the importance of intellectual property protection in China. Holding patents may guarantee protection for an innovative new product.</p

Self-Assembly and External Modulation of a Flexible Porphyrin Derivative on Highly Oriented Pyrolytic Graphite

With the aid of scanning tunneling microscopy, we have examined the two-dimensional hydrogen-bonded networks of carboxyl-functionalized porphyrin derivative H₂TCPp molecules at the heptanoic acid/HOPG interface. Moreover, we have successfully modulated the self-assembly structure of H₂TCPp by introducing 1,2-di­(4-pyridyl)­ethylene molecules into the assembled system. By performing density functional theory calculations, we also revealed the formation mechanisms of the different assemblies and the modulation process. Comparing the self-assembly structures at the liquid/solid interface with those in bulk crystals, we have obtained deep insight into the differences in H₂TCPp assemblies between 2D and 3D networks. Furthermore, this research is expected to deepen our understanding of on-surface phenomena and to provide a feasible process toward 2D assembly regulation